ANAPC5

ANAPC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC5 , APC5, anaphase promoting complex subunit 5
External IDs	OMIM: 606948 MGI: 1929722 HomoloGene: 41118 GeneCards: ANAPC5
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,399,896 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,959,402 bp
RNA expression pattern
	Top expressed in
	Body of pancreas; ; corpus callosum; ; tibia; ; stomach; ; kidney; ; substantia nigra; ; pituitary gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase binding ; GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity ;
Cellular component	nucleoplasm ; cytosol ; nucleus ; anaphase-promoting complex ;
Biological process	cell cycle ; anaphase-promoting complex-dependent catabolic process ; protein ubiquitination ; protein K11-linked ubiquitination ; cell division ; positive regulation of mitotic metaphase/anaphase transition ; regulation of mitotic cell cycle phase transition ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	51433
	59008
	ENSG00000089053
	ENSMUSG00000029472
	Q9UJX4
	Q8BTZ4
	NM_001137559 ; NM_016237 ; NM_001330489
NM_001042491 ; NM_001289517 ; NM_001289518 ; NM_001289519 ; NM_001289520 ;
	NM_021505
	NP_001131031 ; NP_001317418 ; NP_057321
NP_001035956 ; NP_001276446 ; NP_001276447 ; NP_001276448 ; NP_001276449 ;
	NP_067480
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2022

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.^[5]^[6]

Interactions

ANAPC5 has been shown to interact with ANAPC1,^[7]^[8] ANAPC4,^[7] CDC27 ^[7]^[9]^[10] and PABPC1.^[9]

Related Research Articles

The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/C^Cdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.

Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.

Cell division cycle 23 homolog , also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene.

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.

HAUS augmin-like complex subunit 3 is a protein that in humans is encoded by the HAUS3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000089053 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029472 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
1 2 "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".
1 2 3 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.
↑ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.
1 2 Koloteva-Levine, Nadejda; Pinchasi, Dalia; Pereman, Idan; Zur, Amit; Brandeis, Michael; Elroy-Stein, Orna (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753 . PMID 15082755.
↑ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . ISSN 0027-8424. PMC 16806 . PMID 10922056.

External links

Human ANAPC5 genome location and ANAPC5 gene details page in the UCSC Genome Browser .

Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi: 10.1074/jbc.274.20.14500 . PMID 10318877.
Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi: 10.1073/pnas.96.20.11317 . PMC 18031 . PMID 10500174.
Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC 16806 . PMID 10922056.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . PMID 12956947. S2CID 5942532.
Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822 . PMID 14657031.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Koloteva-Levine N, Pinchasi D, Pereman I, et al. (2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. PMC 387753 . PMID 15082755.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Turnell AS, Stewart GS, Grand RJ, et al. (2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature. 438 (7068): 690–5. Bibcode:2005Natur.438..690T. doi:10.1038/nature04151. PMID 16319895. S2CID 4432156.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000089053 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029472 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9469815-5] Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.

[entrez-6] 1 2 "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".

[pmid12956947-7] 1 2 3 Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi: 10.1016/S0960-9822(03)00581-5 . ISSN 0960-9822. PMID 12956947. S2CID 5942532.

[pmid11076961-8] Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443 . PMID 11076961.

[pmid15082755-9] 1 2 Koloteva-Levine, Nadejda; Pinchasi, Dalia; Pereman, Idan; Zur, Amit; Brandeis, Michael; Elroy-Stein, Orna (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753 . PMID 15082755.

[pmid10922056-10] Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . ISSN 0027-8424. PMC 16806 . PMID 10922056.

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ANAPC5

Contents

Interactions

Related Research Articles

References

External links

Further reading