ANAPC5

ANAPC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC5 , APC5, anaphase promoting complex subunit 5
External IDs	OMIM: 606948; MGI: 1929722; HomoloGene: 41118; GeneCards: ANAPC5; OMA:ANAPC5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.31 Start 121,308,245 bp [1] End 121,399,896 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 122,925,522 bp [2] End 122,959,402 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of pancreas bronchial epithelial cell tibia canal of the cervix skin of hip body of uterus corpus callosum tibial nerve right ovary Top expressed in fossa condyle internal carotid artery external carotid artery fetal liver hematopoietic progenitor cell Paneth cell superior cervical ganglion hair follicle trigeminal ganglion vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase binding ubiquitin protein ligase activity Cellular component nucleoplasm cytosol nucleus anaphase-promoting complex Biological process cell cycle anaphase-promoting complex-dependent catabolic process protein ubiquitination protein K11-linked ubiquitination cell division positive regulation of mitotic metaphase/anaphase transition regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51433 59008 Ensembl ENSG00000089053 ENSMUSG00000029472 UniProt Q9UJX4 Q8BTZ4 RefSeq (mRNA) NM_001137559 NM_016237 NM_001330489 NM_001042491 NM_001289517 NM_001289518 NM_001289519 NM_001289520 NM_021505 RefSeq (protein) NP_001131031 NP_001317418 NP_057321 NP_001035956 NP_001276446 NP_001276447 NP_001276448 NP_001276449 NP_067480 Location (UCSC) Chr 12: 121.31 – 121.4 Mb Chr 5: 122.93 – 122.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. ^{[5] [6]}

The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM] ^[6]

Interactions

ANAPC5 has been shown to interact with ANAPC1, ^{[7] [8]} ANAPC4, ^[7] CDC27 ^{[7] [9] [10]} and PABPC1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000089053 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029472 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID   9469815.
6. "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".
7. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . ISSN   0960-9822. PMID   12956947. S2CID   5942532.
8. Sumara I, Vorlaufer E, Gieffers C, Peters B H, Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN   0021-9525. PMC   2169443 . PMID   11076961.
9. Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN   0270-7306. PMC   387753 . PMID   15082755.
10. Gmachl M, Gieffers C, Podtelejnikov A V, Mann M, Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . ISSN   0027-8424. PMC   16806 . PMID   10922056.

External links

• Human ANAPC5 genome location and ANAPC5 gene details page in the UCSC Genome Browser .

Further reading

• Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi: 10.1074/jbc.274.20.14500 . PMID   10318877.
• Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi: 10.1073/pnas.96.20.11317 . PMC   18031 . PMID   10500174.
• Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC   16806 . PMID   10922056.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . PMID   12956947. S2CID   5942532.
• Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC   291822 . PMID   14657031.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Koloteva-Levine N, Pinchasi D, Pereman I, et al. (2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. PMC   387753 . PMID   15082755.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Turnell AS, Stewart GS, Grand RJ, et al. (2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature. 438 (7068): 690–5. Bibcode:2005Natur.438..690T. doi:10.1038/nature04151. PMID   16319895. S2CID   4432156.