ANAPC7

ANAPC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FFL, 4UI9, 5A31, 5G04, 5G05
Identifiers
Aliases	ANAPC7 , APC7, anaphase promoting complex subunit 7, FERBON
External IDs	OMIM: 606949; MGI: 1929711; HomoloGene: 10512; GeneCards: ANAPC7; OMA:ANAPC7 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.11 Start 110,372,900 bp [1] End 110,403,730 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 122,559,756 bp [2] End 122,582,975 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of esophagus skin of arm right testis left testis gonad cerebellar hemisphere right hemisphere of cerebellum right uterine tube vagina Top expressed in otic vesicle saccule otic placode interventricular septum external carotid artery internal carotid artery tunica media of zone of aorta medullary collecting duct epithelium of lens trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase binding protein binding Cellular component nucleoplasm cytosol anaphase-promoting complex nucleus Biological process cell cycle anaphase-promoting complex-dependent catabolic process protein ubiquitination protein K11-linked ubiquitination cell division regulation of mitotic cell cycle phase transition ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51434 56317 Ensembl ENSG00000196510 ENSMUSG00000029466 UniProt Q9UJX3 Q9WVM3 RefSeq (mRNA) NM_001137664 NM_016238 NM_001385208 NM_001385209 NM_001385210 NM_001385211 NM_001385212 NM_019805 RefSeq (protein) NP_001131136 NP_057322 NP_057322.2 NP_062779 Location (UCSC) Chr 12: 110.37 – 110.4 Mb Chr 5: 122.56 – 122.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. ^[5] Multiple transcript variants encoding different isoforms have been found for this gene.

Function

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. ^[5]

Interactions

ANAPC7 has been shown to interact with ANAPC1, ^{[6] [7]} ANAPC4, ^[6] CDC27 ^{[6] [8]} and CDC20. ^{[6] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000196510 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029466 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7".
6. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . PMID   12956947. S2CID   5942532.
7. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC   2169443 . PMID   11076961.
8. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC   16806 . PMID   10922056.
9. Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC   2635557 . PMID   18997788.

External links

• Human ANAPC7 genome location and ANAPC7 gene details page in the UCSC Genome Browser .

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Yu H, Peters JM, King RW, et al. (1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID   9469815.
• Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi: 10.1074/jbc.274.20.14500 . PMID   10318877.
• Chan GK, Jablonski SA, Sudakin V, et al. (1999). "Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC". J. Cell Biol. 146 (5): 941–54. doi:10.1083/jcb.146.5.941. PMC   2169490 . PMID   10477750.
• Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi: 10.1073/pnas.96.20.11317 . PMC   18031 . PMID   10500174.
• Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC   16806 . PMID   10922056.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . PMID   12956947. S2CID   5942532.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Park KH, Choi SE, Eom M, Kang Y (2006). "Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships". Breast Cancer Res. 7 (2): R238–47. doi: 10.1186/bcr978 . PMC   1064132 . PMID   15743504.
• Turnell AS, Stewart GS, Grand RJ, et al. (2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature. 438 (7068): 690–5. Bibcode:2005Natur.438..690T. doi:10.1038/nature04151. PMID   16319895. S2CID   4432156.