ANKRD23

ANKRD23
Identifiers
Aliases	ANKRD23 , DARP, MARP3, ankyrin repeat domain 23
External IDs	OMIM: 610736; MGI: 1925571; HomoloGene: 14025; GeneCards: ANKRD23; OMA:ANKRD23 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q11.2 Start 96,824,526 bp [1] End 96,857,934 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 B Start 36,569,269 bp [2] End 36,575,964 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle sural nerve tibialis anterior muscle skeletal muscle tissue quadriceps femoris muscle vastus lateralis muscle right uterine tube apex of heart biceps brachii Top expressed in quadriceps femoris muscle muscle tissue muscle of thigh skeletal muscle tissue esophagus zone of skin lip heart adrenal gland neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function titin binding Cellular component myofibril nucleus intercalated disc nucleoplasm actin cytoskeleton cytosol Biological process response to mechanical stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200539 78321 Ensembl ENSG00000163126 ENSMUSG00000067653 UniProt Q86SG2 Q812A3 RefSeq (mRNA) NM_144994 NM_153502 NM_001310521 RefSeq (protein) NP_659431 NP_001297450 NP_705722 Location (UCSC) Chr 2: 96.82 – 96.86 Mb Chr 1: 36.57 – 36.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene. ^{[5] [6]}

This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation. ^[6]

Interactions

ANKRD23 has been shown to interact with Titin ^[7] and MYPN. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163126 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067653 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". J Biol Chem. 278 (6): 3514–20. doi: 10.1074/jbc.M204563200 . PMID   12456686.
6. "Entrez Gene: ANKRD23 ankyrin repeat domain 23".
7. Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN   0022-2836. PMID   14583192.

External links

• Human ANKRD23 genome location and ANKRD23 gene details page in the UCSC Genome Browser .

Further reading

• Hillier LW; Graves TA; Fulton RS; et al. (2005), "Generation and annotation of the DNA sequences of human chromosomes 2 and 4", Nature, 434 (7034): 724–31, Bibcode:2005Natur.434..724H, doi: 10.1038/nature03466 , PMID   15815621
• Gerhard DS; Wagner L; Feingold EA; et al. (2004), "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", Genome Res., 14 (10B): 2121–7, doi:10.1101/gr.2596504, PMC   528928 , PMID   15489334
• Nagueh SF; Shah G; Wu Y; et al. (2005), "Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy", Circulation, 110 (2): 155–62, doi: 10.1161/01.CIR.0000135591.37759.AF , PMID   15238456
• Ota T; Suzuki Y; Nishikawa T; et al. (2004), "Complete sequencing and characterization of 21,243 full-length human cDNAs", Nat. Genet., 36 (1): 40–5, doi: 10.1038/ng1285 , PMID   14702039
• Miller MK; Bang ML; Witt CC; et al. (2003), "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules", J. Mol. Biol., 333 (5): 951–64, doi:10.1016/j.jmb.2003.09.012, PMID   14583192
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003), "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", Proc. Natl. Acad. Sci. U.S.A., 99 (26): 16899–903, Bibcode:2002PNAS...9916899M, doi: 10.1073/pnas.242603899 , PMC   139241 , PMID   12477932
• Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000), "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags", Proc. Natl. Acad. Sci. U.S.A., 97 (7): 3491–6, Bibcode:2000PNAS...97.3491D, doi: 10.1073/pnas.97.7.3491 , PMC   16267 , PMID   10737800