ANKRD27

ANKRD27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B93, 4CYM, 4CZ2
Identifiers
Aliases	ANKRD27 , VARP, PP12899, ankyrin repeat domain 27
External IDs	MGI: 2444103; HomoloGene: 12956; GeneCards: ANKRD27; OMA:ANKRD27 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.11 Start 32,597,006 bp [1] End 32,676,597 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B2 Start 35,285,669 bp [2] End 35,338,651 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus amniotic fluid skin of thigh palpebral conjunctiva Brodmann area 23 tail of epididymis seminal vesicula epithelium of nasopharynx lower lobe of lung testicle Top expressed in neural layer of retina ascending aorta lacrimal gland zygote aortic valve tail of embryo lumbar spinal ganglion parotid gland epiblast oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity guanyl-nucleotide exchange factor activity protein binding SNARE binding Cellular component endosome late endosome membrane melanosome plasma membrane transport vesicle tubular endosome early endosome lysosome cytoplasmic vesicle membrane cytoplasmic vesicle cytosol neuron projection Biological process negative regulation of SNARE complex assembly early endosome to late endosome transport positive regulation of dendrite morphogenesis endosome to melanosome transport protein transport positive regulation of GTPase activity neuron projection morphogenesis transport regulation of molecular function positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84079 245886 Ensembl ENSG00000105186 ENSMUSG00000034867 UniProt Q96NW4 Q3UMR0 RefSeq (mRNA) NM_032139 NM_145633 NM_178263 NM_001358876 RefSeq (protein) NP_115515 NP_663608 NP_839994 NP_001345805 Location (UCSC) Chr 19: 32.6 – 32.68 Mb Chr 7: 35.29 – 35.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000105186 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034867 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. Zhang X, He X, Fu XY, Chang Z (Mar 2006). "Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics". J Cell Sci. 119 (Pt 6): 1053–62. doi: 10.1242/jcs.02810 . PMID   16525121.
7. "Entrez Gene: ANKRD27 ankyrin repeat domain 27 (VPS9 domain)".

External links

• Human ANKRD27 genome location and ANKRD27 gene details page in the UCSC Genome Browser .

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.