AP1AR

AP1AR
Identifiers
Aliases	AP1AR , 2C18, C4orf16, GBAR, gamma-BAR, PRO0971, adaptor related protein complex 1 associated regulatory protein
External IDs	OMIM: 610851; MGI: 2384822; HomoloGene: 10236; GeneCards: AP1AR; OMA:AP1AR - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q25 Start 112,231,740 bp [1] End 112,273,110 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G2 Start 127,600,656 bp [2] End 127,631,172 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence jejunal mucosa rectum monocyte testicle ventricular zone mucosa of sigmoid colon stromal cell of endometrium islet of Langerhans Top expressed in trigeminal ganglion epithelium of small intestine conjunctival fornix vestibular membrane of cochlear duct dorsal striatum Ileal epithelium primitive streak corneal stroma entorhinal cortex vestibular sensory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinesin binding AP-1 adaptor complex binding Cellular component late endosome Golgi apparatus early endosome transport vesicle cytosol endosome Biological process protein transport negative regulation of cell motility negative regulation of substrate adhesion-dependent cell spreading regulation of Arp2/3 complex-mediated actin nucleation negative regulation of receptor recycling vesicle targeting, trans-Golgi to endosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55435 211556 Ensembl ENSG00000138660 ENSMUSG00000074238 UniProt Q63HQ0 n/a RefSeq (mRNA) NM_001128426 NM_018569 NM_145964 NM_001346718 RefSeq (protein) NP_001121898 NP_061039 n/a Location (UCSC) Chr 4: 112.23 – 112.27 Mb Chr 3: 127.6 – 127.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a protein that in humans is encoded by the AP1AR gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000138660 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074238 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC   556403 . PMID   15775984.
6. "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

External links

• Human AP1AR genome location and AP1AR gene details page in the UCSC Genome Browser .

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.