AP1AR

AP1AR
Identifiers
Aliases	AP1AR , 2C18, C4orf16, GBAR, gamma-BAR, PRO0971, adaptor related protein complex 1 associated regulatory protein
External IDs	OMIM: 610851; MGI: 2384822; HomoloGene: 10236; GeneCards: AP1AR; OMA:AP1AR - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	112,273,110 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	127,631,172 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; jejunal mucosa; ; rectum; ; monocyte; ; testicle; ; ventricular zone; ; mucosa of sigmoid colon; ; stromal cell of endometrium; ; islet of Langerhans;
	Top expressed in
	trigeminal ganglion; ; epithelium of small intestine; ; conjunctival fornix; ; vestibular membrane of cochlear duct; ; dorsal striatum; ; Ileal epithelium; ; primitive streak; ; corneal stroma; ; entorhinal cortex; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinesin binding ; AP-1 adaptor complex binding ;
Cellular component	late endosome ; Golgi apparatus ; early endosome ; transport vesicle ; cytosol ; endosome ;
Biological process	protein transport ; negative regulation of cell motility ; negative regulation of substrate adhesion-dependent cell spreading ; regulation of Arp2/3 complex-mediated actin nucleation ; negative regulation of receptor recycling ; vesicle targeting, trans-Golgi to endosome ;
	Sources:Amigo / QuickGO
Orthologs
	55435
	211556
	ENSG00000138660
	ENSMUSG00000074238
	Q63HQ0
	n/a
	NM_001128426 ; NM_018569
	NM_145964 ; NM_001346718
	NP_001121898 ; NP_061039
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 20, 2024

AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a protein that in humans is encoded by the AP1AR gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138660 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074238 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC 556403 . PMID 15775984.
↑ "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

External links

Human AP1AR genome location and AP1AR gene details page in the UCSC Genome Browser .

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138660 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074238 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15775984-5] Neubrand VE, Will RD, Mobius W, Poustka A, Wiemann S, Schu P, Dotti CG, Pepperkok R, Simpson JC (Apr 2005). "Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking". EMBO J. 24 (6): 1122–33. doi:10.1038/sj.emboj.7600600. PMC 556403 . PMID 15775984.

[entrez-6] "Entrez Gene: C4orf16 chromosome 4 open reading frame 16".

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AP1AR

Contents

Related Research Articles

References

External links

Further reading