AP1M2

AP1M2
Identifiers
Aliases	AP1M2 , AP1-mu2, HSMU1B, MU-1B, MU1B, mu2, adaptor related protein complex 1 mu 2 subunit, adaptor related protein complex 1 subunit mu 2
External IDs	OMIM: 607309 MGI: 1336974 HomoloGene: 55906 GeneCards: AP1M2
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 10,572,671 bp [1] End 10,587,315 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A3|9 7.76 cM Start 21,205,571 bp [2] End 21,223,633 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum right lobe of thyroid gland oocyte right uterine tube left lobe of thyroid gland islet of Langerhans body of pancreas kidney minor salivary gland skin of abdomen Top expressed in pyloric antrum ileum epithelium of stomach upper respiratory tract olfactory epithelium submandibular gland lip duodenum parotid gland colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol Golgi apparatus trans-Golgi network membrane intracellular membrane-bounded organelle membrane Golgi membrane lysosomal membrane clathrin-coated vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle clathrin adaptor complex Biological process protein targeting vesicle targeting antigen processing and presentation of exogenous peptide antigen via MHC class II mitigation of host defenses by virus protein transport intracellular protein transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10053 11768 Ensembl ENSG00000129354 ENSMUSG00000003309 UniProt Q9Y6Q5 Q9WVP1 RefSeq (mRNA) NM_001300887 NM_005498 NM_001110300 NM_009678 RefSeq (protein) NP_001287816 NP_005489 NP_001103770 NP_033808 Location (UCSC) Chr 19: 10.57 – 10.59 Mb Chr 9: 21.21 – 21.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene. ^{[5] [6]}

Function

This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. ^[6]

Interactions

AP1M2 has been shown to interact with AP2B1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000129354 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003309 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar RC, Foelsch H, Mellman I, Saito T, Shirasawa T, Bonifacino JS (Apr 1999). "Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells". FEBS Letters. 449 (2–3): 215–20. doi: 10.1016/S0014-5793(99)00432-9 . PMID   10338135. S2CID   82686795.
6. "Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Hirst J, Robinson MS (Aug 1998). "Clathrin and adaptors". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1404 (1–2): 173–93. doi: 10.1016/S0167-4889(98)00056-1 . PMID   9714795.
• Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS (Sep 1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science. 269 (5232): 1872–5. Bibcode:1995Sci...269.1872O. doi:10.1126/science.7569928. PMID   7569928.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Seaman MN, Sowerby PJ, Robinson MS (Oct 1996). "Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network". The Journal of Biological Chemistry. 271 (41): 25446–51. doi: 10.1074/jbc.271.41.25446 . PMID   8810314.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Stephens DJ, Banting G (Nov 1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". The Biochemical Journal. 335 (3): 567–72. doi:10.1042/bj3350567. PMC   1219817 . PMID   9794796.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC   103959 . PMID   9882340.
• Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi: 10.1016/S0092-8674(00)81650-5 . PMID   10535737. S2CID   15288582.
• Nakatsu F, Kadohira T, Gilbert DJ, Jenkins NA, Kakuta H, Copeland NG, Saito T, Ohno H (2000). "Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2)". Cytogenetics and Cell Genetics. 87 (1–2): 53–8. doi:10.1159/000015391. PMID   10640811. S2CID   84417943.
• Umeda A, Meyerholz A, Ungewickell E (May 2000). "Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation". European Journal of Cell Biology. 79 (5): 336–42. doi:10.1078/S0171-9335(04)70037-0. PMID   10887964.
• Fölsch H, Pypaert M, Schu P, Mellman I (Feb 2001). "Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells". The Journal of Cell Biology. 152 (3): 595–606. doi:10.1083/jcb.152.3.595. PMC   2195989 . PMID   11157985.
• Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M (Mar 2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". Journal of Virology. 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC   115924 . PMID   11222723.
• Ohka S, Ohno H, Tohyama K, Nomoto A (Oct 2001). "Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells". Biochemical and Biophysical Research Communications. 287 (4): 941–8. doi:10.1006/bbrc.2001.5660. PMID   11573956.
• Korolchuk VI, Banting G (Jun 2002). "CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles". Traffic. 3 (6): 428–39. doi:10.1034/j.1600-0854.2002.30606.x. PMID   12010461. S2CID   34467416.
• Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ (May 2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. doi: 10.1016/S0092-8674(02)00735-3 . PMID   12086608. S2CID   483953.
• Sugimoto H, Sugahara M, Fölsch H, Koide Y, Nakatsu F, Tanaka N, Nishimura T, Furukawa M, Mullins C, Nakamura N, Mellman I, Ohno H (Jul 2002). "Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells". Molecular Biology of the Cell. 13 (7): 2374–82. doi:10.1091/mbc.E01-10-0096. PMC   117320 . PMID   12134076.

External links

• AP1M2 human gene location in the UCSC Genome Browser .
• AP1M2 human gene details in the UCSC Genome Browser .