APBA3

Last updated
APBA3
Protein APBA3 PDB 2YT7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases APBA3 , MGC:15815, X11L2, mint3, amyloid beta precursor protein binding family A member 3
External IDs OMIM: 604262; MGI: 1888527; HomoloGene: 3591; GeneCards: APBA3; OMA:APBA3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004886

NM_018758

RefSeq (protein)

NP_004877

NP_061228

Location (UCSC) Chr 19: 3.75 – 3.76 Mb Chr 10: 81.1 – 81.11 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [6]

Interactions

APBA3 has been shown to interact with Amyloid precursor protein. [5] [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000011132 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004931 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Tanahashi H, Tabira T (Apr 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein". Biochem Biophys Res Commun. 255 (3): 663–7. doi:10.1006/bbrc.1999.0265. PMID   10049767.
  6. 1 2 "Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)".
  7. Biederer T, Cao X, Südhof TC, Liu X (Sep 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. 22 (17): 7340–51. doi: 10.1523/JNEUROSCI.22-17-07340.2002 . PMC   6757996 . PMID   12196555.

Further reading