ARFGEF1

ARFGEF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LTL, 5EE5
Identifiers
Aliases	ARFGEF1 , ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDs	OMIM: 604141 MGI: 2442988 HomoloGene: 4687 GeneCards: ARFGEF1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	67,343,781 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	10,302,895 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sural nerve; ; bronchial epithelial cell; ; jejunal mucosa; ; bone marrow; ; tibia; ; testicle; ; bone marrow cells; ; spongy bone; ; amniotic fluid;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; submandibular gland; ; cumulus cell; ; knee joint; ; triceps brachii muscle; ; plantaris muscle; ; lacrimal gland; ; gastric mucosa; ; pituitary gland; ; epithelium of stomach;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity ; guanyl-nucleotide exchange factor activity ; myosin binding ; protein binding ; protein kinase A regulatory subunit binding ;
Cellular component	cytosol ; Golgi apparatus ; membrane ; nuclear matrix ; Golgi membrane ; nucleoplasm ; trans-Golgi network ; nucleolus ; small nuclear ribonucleoprotein complex ; perinuclear region of cytoplasm ; nucleus ; cytoplasm ;
Biological process	endomembrane system organization ; positive regulation of protein kinase B signaling ; negative regulation of actin filament polymerization ; Golgi organization ; positive regulation of wound healing ; regulation of ARF protein signal transduction ; negative regulation of GTPase activity ; protein transport ; neuron projection development ; regulation of establishment of cell polarity ; exocytosis ; positive regulation of GTPase activity ; vesicle-mediated transport ;
	Sources:Amigo / QuickGO
Orthologs
	10565
	211673
	ENSG00000066777
	ENSMUSG00000067851
	Q9Y6D6
	G3X9K3
	NM_006421
	NM_001102430
	NP_006412
	NP_001095900
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 26, 2024

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.^[5]^[6]^[7]

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.^[7]

Interactions

ARFGEF1 has been shown to interact with FKBP2,^[8] ARFGEF2 ^[9] and PRKAR1A.^[10]

Related Research Articles

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.

Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene. Two transcript variants encoding different isoforms have been found for this gene.

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000066777 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067851 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi: 10.1074/jbc.274.18.12308 . PMID 10212200.
↑ Morinaga N, Tsai SC, Moss J, Vaughan M (Nov 1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12856–60. Bibcode:1996PNAS...9312856M. doi: 10.1073/pnas.93.23.12856 . PMC 24010 . PMID 8917509.
1 2 "Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)".
↑ Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2322–7. Bibcode:2003PNAS..100.2322P. doi: 10.1073/pnas.2628047100 . PMC 151339 . PMID 12606707.
↑ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi: 10.1073/pnas.97.6.2567 . PMC 15969 . PMID 10716990.
↑ Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi: 10.1073/pnas.0337678100 . PMC 149883 . PMID 12571360.

External links

Human ARFGEF1 genome location and ARFGEF1 gene details page in the UCSC Genome Browser .

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Mansour SJ, Skaug J, Zhao XH, Giordano J, Scherer SW, Melançon P (Jul 1999). "p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A". Proceedings of the National Academy of Sciences of the United States of America. 96 (14): 7968–73. Bibcode:1999PNAS...96.7968M. doi: 10.1073/pnas.96.14.7968 . PMC 22171 . PMID 10393931.
Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi: 10.1073/pnas.97.6.2567 . PMC 15969 . PMID 10716990.
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (Jan 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (Mar 2004). "Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". Proceedings of the National Academy of Sciences of the United States of America. 101 (9): 2752–7. Bibcode:2004PNAS..101.2752P. doi: 10.1073/pnas.0307345101 . PMC 365693 . PMID 14973189.
Saeki N, Tokuo H, Ikebe M (Mar 2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". The Journal of Biological Chemistry. 280 (11): 10128–34. doi: 10.1074/jbc.M413415200 . PMID 15644318.
Citterio C, Jones HD, Pacheco-Rodriguez G, Islam A, Moss J, Vaughan M (Feb 2006). "Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei". Proceedings of the National Academy of Sciences of the United States of America. 103 (8): 2683–8. Bibcode:2006PNAS..103.2683C. doi: 10.1073/pnas.0510571103 . PMC 1413798 . PMID 16467138.
Belov GA, Altan-Bonnet N, Kovtunovych G, Jackson CL, Lippincott-Schwartz J, Ehrenfeld E (Jan 2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA". Journal of Virology. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456 . PMID 17079330.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Shen X, Hong MS, Moss J, Vaughan M (Jan 2007). "BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1". Proceedings of the National Academy of Sciences of the United States of America. 104 (4): 1230–5. Bibcode:2007PNAS..104.1230S. doi: 10.1073/pnas.0610535104 . PMC 1783117 . PMID 17227842.
Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3201–6. Bibcode:2007PNAS..104.3201K. doi: 10.1073/pnas.0611696104 . PMC 1805514 . PMID 17360629.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000066777 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067851 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10212200-5] Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi: 10.1074/jbc.274.18.12308 . PMID 10212200.

[pmid8917509-6] Morinaga N, Tsai SC, Moss J, Vaughan M (Nov 1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12856–60. Bibcode:1996PNAS...9312856M. doi: 10.1073/pnas.93.23.12856 . PMC 24010 . PMID 8917509.

[entrez-7] 1 2 "Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)".

[pmid12606707-8] Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2322–7. Bibcode:2003PNAS..100.2322P. doi: 10.1073/pnas.2628047100 . PMC 151339 . PMID 12606707.

[pmid10716990-9] Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi: 10.1073/pnas.97.6.2567 . PMC 15969 . PMID 10716990.

[pmid12571360-10] Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi: 10.1073/pnas.0337678100 . PMC 149883 . PMID 12571360.

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