ARFGEF2

ARFGEF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L8N, 3SWV
Identifiers
Aliases	ARFGEF2 , BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2
External IDs	OMIM: 605371 MGI: 2139354 HomoloGene: 111880 GeneCards: ARFGEF2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,036,693 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	166,739,972 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; parotid gland; ; corpus epididymis; ; cardia; ; secondary oocyte; ; retinal pigment epithelium; ; caput epididymis; ; tibia; ; lactiferous duct; ; cavity of mouth;
	Top expressed in
	retinal pigment epithelium; ; lacrimal gland; ; secondary oocyte; ; submandibular gland; ; superior cervical ganglion; ; epithelium of stomach; ; interventricular septum; ; medial vestibular nucleus; ; ciliary body; ; spinal ganglia;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity ; GABA receptor binding ; myosin binding ; protein binding ; protein kinase A regulatory subunit binding ;
Cellular component	cytoplasm ; recycling endosome ; cytosol ; endosome ; Golgi apparatus ; cell projection ; membrane ; Golgi membrane ; dendritic spine ; synapse ; microtubule organizing center ; cell junction ; trans-Golgi network ; dendrite ; symmetric synapse ; asymmetric synapse ; perinuclear region of cytoplasm ; cytoskeleton ; cytoplasmic vesicle ; axonemal microtubule ;
Biological process	endomembrane system organization ; intracellular signal transduction ; regulation of ARF protein signal transduction ; endosome organization ; receptor recycling ; positive regulation of tumor necrosis factor production ; protein transport ; Golgi to plasma membrane transport ; exocytosis ; transport ; regulation of molecular function ; vesicle-mediated transport ;
	Sources:Amigo / QuickGO
Orthologs
	10564
	99371
	ENSG00000124198
	ENSMUSG00000074582
	Q9Y6D5
	A2A5R2
	NM_006420
	NM_001085495
	NP_006411
	NP_001078964
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 02, 2023

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.^[5]^[6]

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.^[6]

Interactions

ARFGEF2 has been shown to interact with ARFGEF1,^[7] PRKAR1A ^[8] and PRKAR2A.^[8]

Related Research Articles

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene.

Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene. Two transcript variants encoding different isoforms have been found for this gene.

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.

FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.

Arfaptin-1 is a protein that in humans is encoded by the ARFIP1 gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124198 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074582 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi: 10.1074/jbc.274.18.12308 . PMID 10212200.
1 2 "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)".
↑ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi: 10.1073/pnas.97.6.2567 . PMC 15969 . PMID 10716990.
1 2 Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi: 10.1073/pnas.0337678100 . PMC 149883 . PMID 12571360.

External links

Human ARFGEF2 genome location and ARFGEF2 gene details page in the UCSC Genome Browser .

Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi: 10.1073/pnas.97.6.2567 . PMC 15969 . PMID 10716990.
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors". G Protein Pathways - Part C, Effector Mechanisms. Methods in Enzymology. Vol. 345. pp. 397–404. doi:10.1016/S0076-6879(02)45032-X. ISBN 9780121822460. PMID 11665623.
Shinotsuka C, Yoshida Y, Kawamoto K, Takatsu H, Nakayama K (Mar 2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation". The Journal of Biological Chemistry. 277 (11): 9468–73. doi: 10.1074/jbc.M112427200 . PMID 11777925.
Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K (Jun 2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins". Biochemical and Biophysical Research Communications. 294 (2): 254–60. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.
Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi: 10.1073/pnas.0337678100 . PMC 149883 . PMID 12571360.
Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA (Jan 2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex". Nature Genetics. 36 (1): 69–76. doi: 10.1038/ng1276 . PMID 14647276.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proceedings of the National Academy of Sciences of the United States of America. 102 (8): 2784–9. Bibcode:2005PNAS..102.2784X. doi: 10.1073/pnas.0409871102 . PMC 549493 . PMID 15705715.
Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V (Jan 2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia". The Journal of Comparative Neurology. 494 (3): 476–84. doi:10.1002/cne.20806. PMID 16320251. S2CID 16527134.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ (Mar 2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles". The Journal of Biological Chemistry. 282 (13): 9591–9. doi: 10.1074/jbc.M607122200 . PMID 17276987.
Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3201–6. Bibcode:2007PNAS..104.3201K. doi: 10.1073/pnas.0611696104 . PMC 1805514 . PMID 17360629.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124198 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074582 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10212200-5] Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi: 10.1074/jbc.274.18.12308 . PMID 10212200.

[entrez-6] 1 2 "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)".

[pmid10716990-7] Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. Bibcode:2000PNAS...97.2567Y. doi: 10.1073/pnas.97.6.2567 . PMC 15969 . PMID 10716990.

[pmid12571360-8] 1 2 Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. Bibcode:2003PNAS..100.1627L. doi: 10.1073/pnas.0337678100 . PMC 149883 . PMID 12571360.

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