ARFRP1

Last updated
ARFRP1
Identifiers
Aliases ARFRP1 , ARL18, ARP, Arp1, ADP ribosylation factor related protein 1
External IDs OMIM: 604699; MGI: 1923938; HomoloGene: 2425; GeneCards: ARFRP1; OMA:ARFRP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001165991
NM_001165992
NM_001165995
NM_029702

RefSeq (protein)

NP_001159463
NP_001159464
NP_001159467
NP_083978

Location (UCSC) Chr 20: 63.7 – 63.71 Mb Chr 2: 181 – 181.01 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors. [6]

Interactions

ARFRP1 has been shown to interact with PSCD1. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101246 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038671 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem. 270 (51): 30657–63. doi: 10.1074/jbc.270.51.30657 . PMID   8530503.
  6. 1 2 "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1".
  7. Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi: 10.1074/jbc.274.14.9744 . PMID   10092663.

Further reading