ARGLU1

ARGLU1
Identifiers
Aliases	ARGLU1 , arginine and glutamate rich 1
External IDs	OMIM: 614046; MGI: 2442985; HomoloGene: 9960; GeneCards: ARGLU1; OMA:ARGLU1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q33.3 Start 106,541,673 bp [1] End 106,568,137 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A1.1 Start 8,715,075 bp [2] End 8,740,521 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube germinal epithelium epithelium of nasopharynx hair follicle right lung right hemisphere of cerebellum seminal vesicula skin of hip superficial temporal artery Top expressed in renal corpuscle medullary collecting duct ciliary body epithelium of lens vestibular membrane of cochlear duct vestibular sensory epithelium Paneth cell primitive streak corneal stroma conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding cadherin binding Cellular component mitochondrion nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55082 234023 Ensembl ENSG00000134884 ENSMUSG00000040459 UniProt Q9NWB6 Q3UL36 RefSeq (mRNA) NM_018011 NM_176849 RefSeq (protein) NP_060481 NP_789819 Location (UCSC) Chr 13: 106.54 – 106.57 Mb Chr 8: 8.72 – 8.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arginine and glutamate-rich protein 1 is a protein that in humans is encoded by the ARGLU1 gene located at 13q33.3. ^[5]

The protein product of this gene has been proposed as a MED1-interacting protein required for estrogen-dependent gene transcription and breast cancer cell growth. ^[6]

The ARGLU1 gene expresses at least three distinct RNA splice isoforms - a fully spliced isoform coding for the protein, an isoform containing a retained intron that is detained in the nucleus, and an isoform containing an alternative exon that targets the transcript for nonsense mediated decay. Furthermore, ARGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (UCE) that is within the retained intron and overlaps the alternative exon. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000134884 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040459 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ARGLU1 arginine and glutamate rich 1".
6. Zhang D, Jiang P, Xu Q, Zhang X (May 2011). "Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth". J. Biol. Chem. 286 (20): 17746–54. doi: 10.1074/jbc.M110.206029 . PMC   3093850 . PMID   21454576.
7. Pirnie SP, Osman A, Zhu Y, Carmichael GG (April 2017). "An Ultraconserved Element (UCE) controls homeostatic splicing of ARGLU1 mRNA". Nucleic Acids Res. 45 (6): 3473–3486. doi:10.1093/nar/gkw1140. PMC   5389617 . PMID   27899669.

External links

• Human ARGLU1 genome location and ARGLU1 gene details page in the UCSC Genome Browser .