ARHGAP8

ARHGAP8
Identifiers
Aliases	ARHGAP8 , BPGAP1, PP610, Rho GTPase activating protein 8
External IDs	OMIM: 609405; MGI: 1920417; HomoloGene: 23645; GeneCards: ARHGAP8; OMA:ARHGAP8 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.31 Start 44,752,558 bp [1] End 44,862,788 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E2 Start 84,604,253 bp [2] End 84,656,408 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left lobe of thyroid gland right lobe of thyroid gland mucosa of transverse colon body of pancreas minor salivary glands anterior pituitary spleen rectum human kidney Top expressed in seminal vesicula yolk sac parotid gland blastocyst vestibular membrane of cochlear duct zygote epithelium of stomach vestibular sensory epithelium secondary oocyte genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm cytosol Biological process regulation of small GTPase mediated signal transduction signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23779 73167 Ensembl ENSG00000241484 ENSMUSG00000078954 UniProt P85298 Q9CXP4 RefSeq (mRNA) NM_181335 NM_001017526 NM_001198726 NM_001164627 NM_001164628 NM_001205334 NM_028455 RefSeq (protein) NP_001017526 NP_001185655 NP_851852 NP_001158099 NP_001158100 NP_001192263 NP_082731 Location (UCSC) Chr 22: 44.75 – 44.86 Mb Chr 15: 84.6 – 84.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene. ^{[5] [6]}

Function

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000241484 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078954 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
6. "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8".

External links

• Human ARHGAP8 genome location and ARHGAP8 gene details page in the UCSC Genome Browser .

Further reading

• Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. Bibcode:2002FEBSL.528...27P. doi:10.1016/S0014-5793(02)03331-8. PMID   12297274. S2CID   30443852.
• Shan Z, Haaf T, Popescu NC (2003). "Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8". Gene. 303: 55–61. doi:10.1016/S0378-1119(02)01143-5. PMID   12559566.
• Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–45914. doi: 10.1074/jbc.M304514200 . PMID   12944407.
• Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration". Mol. Biol. Cell. 15 (6): 2873–2883. doi:10.1091/mbc.E04-02-0141. PMC   420110 . PMID   15064355.
• Johnstone CN, Castellví-Bel S, Chang LM, Bessa X, Nakagawa H, Harada H, Sung RK, Piqué JM, Castells A, Rustgi AK (2004). "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers". Gene. 336 (1): 59–71. doi:10.1016/j.gene.2004.01.025. PMID   15225876.
• Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID   15506981.
• Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell Sci. 118 (Pt 12): 2707–2721. doi: 10.1242/jcs.02383 . PMID   15944398.