ARHGEF10

ARHGEF10
Identifiers
Aliases	ARHGEF10 , GEF10, SNCV, Rho guanine nucleotide exchange factor 10
External IDs	OMIM: 608136 MGI: 2444453 HomoloGene: 22827 GeneCards: ARHGEF10
Gene location (Human)
Chr.	Chromosome 8 (human)
End	1,958,641 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	15,001,085 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right lung; ; corpus callosum; ; upper lobe of left lung; ; ascending aorta; ; gastric mucosa; ; Achilles tendon; ; left coronary artery; ; popliteal artery; ; myometrium;
	Top expressed in
	sciatic nerve; ; submandibular gland; ; ascending aorta; ; globus pallidus; ; aortic valve; ; molar; ; optic nerve; ; ventral tegmental area; ; pontine nuclei; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; kinesin binding ; guanyl-nucleotide exchange factor activity ;
Cellular component	cytosol ; centrosome ;
Biological process	mitotic spindle assembly ; regulation of Rho protein signal transduction ; positive regulation of stress fiber assembly ; myelination in peripheral nervous system ; centrosome duplication ; activation of GTPase activity ; actin cytoskeleton organization ;
	Sources:Amigo / QuickGO
Orthologs
	9639
	234094
	ENSG00000104728 ; ENSG00000274726
	ENSMUSG00000071176
	O15013
	Q8C033
	NM_001308152 ; NM_001308153 ; NM_014629
	NM_001037736 ; NM_172751
	NP_001295081 ; NP_001295082 ; NP_055444
	NP_001032825 ; NP_766339
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 10, 2024

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.^[5]^[6]^[7]

Related Research Articles

Alsin is a protein that in humans is encoded by the ALS2 gene. ALS2 orthologs have been identified in all mammals for which complete genome data are available.

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.

Rho-related BTB domain-containing protein 2 is a protein that in humans is encoded by the RHOBTB2 gene.

Netrin-G2 is a protein that in humans is encoded by the NTNG2 gene.

Secernin-1 is a protein that in humans is encoded by the SCRN1 gene.

Regulation of nuclear pre-mRNA domain-containing protein 2 is a protein that in humans is encoded by the RPRD2 gene.

Kelch-like protein 8 is a protein that in humans is encoded by the KLHL8 gene.

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

Dedicator of cytokinesis protein 9 (Dock9), also known as Zizimin1, is a large protein encoded in the human by the DOCK9 gene, involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G-proteins. Dock9 activates the small G protein Cdc42.

PH and SEC7 domain-containing protein 3 is a protein that in humans is encoded by the PSD3 gene.

Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene.

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.

Centrosomal protein of 72 kDa is a protein that in humans is encoded by the CEP72 gene.

References

1 2 3 ENSG00000274726 GRCh38: Ensembl release 89: ENSG00000104728, ENSG00000274726 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071176 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, et al. (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID 9205841.
↑ Mohl M, Winkler S, Wieland T, Lutz S (Aug 2006). "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture". Naunyn-Schmiedeberg's Arch Pharmacol. 373 (5): 333–41. doi:10.1007/s00210-006-0083-0. PMID 16896804. S2CID 29822779.
1 2 "Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10".

External links

Human ARHGEF10 genome location and ARHGEF10 gene details page in the UCSC Genome Browser .

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, et al. (2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Molecular Psychiatry. 13 (11): 1060–8. doi: 10.1038/sj.mp.4002080 . PMID 17893707.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Verhoeven K, De Jonghe P, Van de Putte T, Nelis E, Zwijsen A, Verpoorten N, et al. (2003). "Slowed Conduction and Thin Myelination of Peripheral Nerves Associated with Mutant Rho Guanine-Nucleotide Exchange Factor 10". Am. J. Hum. Genet. 73 (4): 926–32. doi:10.1086/378159. PMC 1180612 . PMID 14508709.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ranta S, Lehesjoki AE, de Fatima Bonaldo M, Knowles JA, Hirvasniemi A, Ross B, et al. (1997). "High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p". Genome Res. 7 (9): 887–96. doi: 10.1101/gr.7.9.887 . PMID 9314494.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000274726 GRCh38: Ensembl release 89: ENSG00000104728, ENSG00000274726 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071176 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9205841-5] Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, et al. (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi: 10.1093/dnares/4.2.141 . PMID 9205841.

[pmid16896804-6] Mohl M, Winkler S, Wieland T, Lutz S (Aug 2006). "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture". Naunyn-Schmiedeberg's Arch Pharmacol. 373 (5): 333–41. doi:10.1007/s00210-006-0083-0. PMID 16896804. S2CID 29822779.

[entrez-7] 1 2 "Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

ARHGEF10

Contents

Related Research Articles

References

External links

Further reading