ARHGEF5

ARHGEF5
Identifiers
Aliases	ARHGEF5 , GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDs	OMIM: 600888 MGI: 1858952 HomoloGene: 66300 GeneCards: ARHGEF5
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q35 Start 144,355,288 bp [1] End 144,380,632 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 43,242,516 bp [2] End 43,266,254 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen left lobe of thyroid gland right lobe of thyroid gland duodenum minor salivary gland kidney body of pancreas prostate vagina islet of Langerhans Top expressed in Epithelium of stomach duodenum lip jejunum large intestine colon pyloric antrum mucous cell of stomach left colon ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP binding protein binding lipid binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cell projection plasma membrane nucleoplasm cell junction podosome nucleus cell periphery cytosol Biological process intracellular signal transduction regulation of actin cytoskeleton organization positive regulation of JUN kinase activity regulation of GTPase activity positive regulation of DNA-binding transcription factor activity positive regulation of podosome assembly myeloid dendritic cell chemotaxis positive regulation of GTPase activity positive regulation of protein import regulation of ERK1 and ERK2 cascade regulation of Rho protein signal transduction regulation of cytoskeleton organization actin cytoskeleton organization positive regulation of stress fiber assembly positive regulation of apoptotic process regulation of small GTPase mediated signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7984 54324 Ensembl ENSG00000050327 ENSMUSG00000033542 UniProt Q12774 E9Q7D5 RefSeq (mRNA) NM_001002861 NM_005435 NM_133674 RefSeq (protein) NP_005426 NP_598435 Location (UCSC) Chr 7: 144.36 – 144.38 Mb Chr 6: 43.24 – 43.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene. ^{[5] [6] [7]}

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000050327 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033542 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene. 9 (4): 1057–63. PMID   8134109.
6. Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet. 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID   7656213.
7. "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5".

External links

• Human ARHGEF5 genome location and ARHGEF5 gene details page in the UCSC Genome Browser .

Further reading

• Snyder JT, Worthylake DK, Rossman KL, et al. (2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nat. Struct. Biol. 9 (6): 468–75. doi:10.1038/nsb796. PMID   12006984. S2CID   13161854.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID   12107413.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Umetsu DT, Dekruyff RH (2005). "Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment". Ann. N. Y. Acad. Sci. 1029 (1): 88–93. doi:10.1196/annals.1309.012. PMID   15681748. S2CID   38149688.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID   15951569.