ARL4A

ARL4A
Identifiers
Aliases	ARL4A , ARL4, ADP ribosylation factor like GTPase 4A
External IDs	OMIM: 604786 MGI: 99437 HomoloGene: 4194 GeneCards: ARL4A
Gene location (Human)
Chr.	Chromosome 7 (human)
End	12,690,958 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	40,088,024 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; vagina; ; Achilles tendon; ; rectum; ; bone marrow; ; smooth muscle tissue; ; duodenum; ; monocyte; ; thymus; ; subcutaneous adipose tissue;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; ascending aorta; ; brown adipose tissue; ; white adipose tissue; ; intercostal muscle; ; subcutaneous adipose tissue; ; molar; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; protein binding ;
Cellular component	plasma membrane ; nucleolus ; intracellular anatomical structure ; membrane ; nucleus ; nucleoplasm ; cytoplasm ; cytosol ;
Biological process	brown fat cell differentiation ; intracellular protein transport ; vesicle-mediated transport ;
	Sources:Amigo / QuickGO
Orthologs
	10124
	11861
	ENSG00000122644
	ENSMUSG00000047446
	P40617
	P61213
	NM_212460 ; NM_001037164 ; NM_001195396 ; NM_005738
	NM_001039515 ; NM_007487
	NP_001032241 ; NP_001182325 ; NP_005729 ; NP_997625
	NP_001034604 ; NP_031513
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 29, 2023

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.^[5]

Function

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.^[5]

Interactions

ARL4A has been shown to interact with Karyopherin alpha 2.^[6]

Related Research Articles

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA2 gene.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

Cytohesin-2 is a protein that in humans is encoded by the CYTH2 gene.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene. Two transcript variants encoding different isoforms have been found for this gene.

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein that in humans is encoded by the ARL13B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000122644 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047446 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A".
↑ Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi: 10.1074/jbc.M002470200 . PMID 10980193.

External links

ARL4A human gene location in the UCSC Genome Browser .
ARL4A human gene details in the UCSC Genome Browser .

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000122644 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047446 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A".

[pmid10980193-6] Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi: 10.1074/jbc.M002470200 . PMID 10980193.

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