ARMCX1

ARMCX1
Identifiers
Aliases	ARMCX1 , ALEX1, GASP7, armadillo repeat containing, X-linked 1, armadillo repeat containing X-linked 1
External IDs	OMIM: 300362 MGI: 1925498 HomoloGene: 9589 GeneCards: ARMCX1
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.1 Start 101,550,547 bp [1] End 101,554,700 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X E3 Start 133,618,712 bp [2] End 133,622,666 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura Brodmann area 23 right ventricle visceral pleura glomerulus metanephric glomerulus myocardium biceps brachii seminal vesicula Top expressed in superior cervical ganglion pontine nuclei facial motor nucleus ventral tegmental area habenula dorsomedial hypothalamic nucleus medial dorsal nucleus inferior colliculus barrel cortex medial vestibular nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 51309 78248 Ensembl ENSG00000126947 ENSMUSG00000033460 UniProt Q9P291 Q9CX83 RefSeq (mRNA) NM_016608 NM_001166377 NM_001166378 NM_001166379 NM_001166380 NM_030066 RefSeq (protein) NP_057692 NP_001159849 NP_001159850 NP_001159851 NP_001159852 NP_084342 Location (UCSC) Chr X: 101.55 – 101.55 Mb Chr X: 133.62 – 133.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Armadillo repeat-containing X-linked protein 1 is a protein that in humans is encoded by the ARMCX1 gene. ^{[5] [6]}

This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000126947 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033460 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas". Biochem Biophys Res Commun. 280 (1): 340–347. doi:10.1006/bbrc.2000.4125. PMID   11162520.
6. "Entrez Gene: ARMCX1 armadillo repeat containing, X-linked 1".

External links

• Human ARMCX1 genome location and ARMCX1 gene details page in the UCSC Genome Browser .

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–337. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.