ARMCX3

ARMCX3
Identifiers
Aliases	ARMCX3 , ALEX3, GASP6, dJ545K15.2, armadillo repeat containing, X-linked 3, armadillo repeat containing X-linked 3
External IDs	OMIM: 300364 MGI: 1918953 HomoloGene: 9588 GeneCards: ARMCX3
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.1 Start 101,622,797 bp [1] End 101,627,843 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X E3 Start 133,657,344 bp [2] End 133,662,204 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus spinal ganglia corpus epididymis pons cardia superior vestibular nucleus pylorus inferior ganglion of vagus nerve lactiferous duct body of pancreas Top expressed in ovary hippocampus proper neural tube pancreas superior frontal gyrus islet of Langerhans cerebellar cortex mesencephalon mirror stomach More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 51566 71703 Ensembl ENSG00000102401 ENSMUSG00000049047 UniProt Q9UH62 Q8BHS6 RefSeq (mRNA) NM_016607 NM_177947 NM_177948 NM_027870 NM_001358520 NM_001358521 RefSeq (protein) NP_057691 NP_808816 NP_808817 NP_057691.1 NP_808816.1 NP_808817.1 NP_082146 NP_001345449 NP_001345450 Location (UCSC) Chr X: 101.62 – 101.63 Mb Chr X: 133.66 – 133.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Armadillo repeat-containing X-linked protein 3 is a protein that in humans is encoded by the ARMCX3 gene. ^{[5] [6] [7] [8]}

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000102401 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049047 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas". Biochem Biophys Res Commun. 280 (1): 340–7. doi:10.1006/bbrc.2000.4125. PMID   11162520.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
7. Mou Z, Tapper AR, Gardner PD (May 2009). "The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally Interacts with the Developmental Regulatory Factor Sox10". J Biol Chem. 284 (20): 13629–40. doi: 10.1074/jbc.M901177200 . PMC   2679464 . PMID   19304657.
8. "Entrez Gene: ARMCX3 armadillo repeat containing, X-linked 3".

External links

• Human ARMCX3 genome location and ARMCX3 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID   12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.