ARPP-19

ARPP19
Identifiers
Aliases	ARPP19 , ARPP-16, ARPP-19, ARPP16, ENSAL, cAMP regulated phosphoprotein 19kDa, cAMP regulated phosphoprotein 19
External IDs	OMIM: 605487; MGI: 1891691; HomoloGene: 21318; GeneCards: ARPP19; OMA:ARPP19 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q21.2 Start 52,547,045 bp [1] End 52,569,883 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 D Start 75,037,614 bp [2] End 75,060,313 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex external globus pallidus nucleus accumbens putamen caudate nucleus optic nerve middle frontal gyrus Brodmann area 10 dorsolateral prefrontal cortex Brodmann area 9 Top expressed in superior frontal gyrus olfactory tubercle yolk sac globus pallidus primary motor cortex nucleus accumbens prefrontal cortex primary visual cortex right kidney embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 2A binding potassium channel regulator activity signaling receptor binding phosphatase inhibitor activity protein phosphatase inhibitor activity protein phosphatase regulator activity Cellular component nucleoplasm cytoplasm Biological process cell division positive regulation of glucose import cell cycle positive regulation of gluconeogenesis G2/M transition of mitotic cell cycle negative regulation of catalytic activity negative regulation of protein dephosphorylation mitotic cell cycle negative regulation of phosphoprotein phosphatase activity regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10776 59046 Ensembl ENSG00000128989 ENSMUSG00000007656 UniProt P56211 P56212 RefSeq (mRNA) NM_001306191 NM_001306195 NM_001306196 NM_006628 NM_001330309 NM_001142655 NM_021548 RefSeq (protein) NP_001293120 NP_001293124 NP_001293125 NP_001317238 NP_006619 NP_001136127 NP_067523 NP_001344807 NP_001344808 NP_001344809 NP_001344810 Location (UCSC) Chr 15: 52.55 – 52.57 Mb Chr 9: 75.04 – 75.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

cAMP-regulated phosphoprotein 19 is a protein that in humans is encoded by the ARPP19 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000128989 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007656 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC (2001). "ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins". J. Neurochem. 77 (1): 229–38. doi:10.1046/j.1471-4159.2001.t01-1-00191.x (inactive 20 October 2025). PMID   11279279.
6. Peyrollier K, Héron L, Virsolvy-Vergine A, Le Cam A, Bataille D (1996). "Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins". Biochem. Biophys. Res. Commun. 223 (3): 583–6. Bibcode:1996BBRC..223..583P. doi:10.1006/bbrc.1996.0938. PMID   8687439.
7. "Entrez Gene: ARPP-19 cyclic AMP phosphoprotein, 19 kD".

External links

• Human ARPP19 genome location and ARPP19 gene details page in the UCSC Genome Browser .

Further reading

• Kim SH, Nairn AC, Cairns N, Lubec G (2001). "Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease". Protein Expression in Down Syndrome Brain. pp. 263–72. doi:10.1007/978-3-7091-6262-0_21. ISBN   978-3-211-83704-7. PMID   11771749.{{cite book}}: |journal= ignored (help)
• Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID   10754390.
• Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (1998). "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8387–91. Bibcode:1998PNAS...95.8387H. doi: 10.1073/pnas.95.14.8387 . PMC   20985 . PMID   9653196.
• Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC   6577526 . PMID   8120638.
• Horiuchi A, Williams KR, Kurihara T, Nairn AC, Greengard P (1990). "Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19". J. Biol. Chem. 265 (16): 9476–84. doi: 10.1016/S0021-9258(19)38874-X . PMID   2160982.