ASB2

ASB2
Identifiers
Aliases	ASB2 , ASB-2, ankyrin repeat and SOCS box containing 2
External IDs	OMIM: 605759 MGI: 1929743 HomoloGene: 69202 GeneCards: ASB2
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.12 Start 93,934,166 bp [1] End 93,976,739 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 E|12 52.9 cM Start 103,287,401 bp [2] End 103,322,260 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skeletal muscle tissue gastrocnemius muscle left ventricle smooth muscle tissue left uterine tube right coronary artery thoracic aorta myometrium ascending aorta popliteal artery Top expressed in knee joint vastus lateralis muscle triceps brachii muscle temporal muscle myocardium of ventricle tibialis anterior muscle sternocleidomastoid muscle digastric muscle skeletal muscle tissue soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase activity Cellular component Cul5-RING ubiquitin ligase complex cytosol ubiquitin ligase complex Biological process skeletal muscle cell differentiation myoblast differentiation intracellular signal transduction protein polyubiquitination signal transduction post-translational protein modification protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51676 65256 Ensembl ENSG00000100628 ENSG00000278693 ENSMUSG00000021200 UniProt Q96Q27 Q8K0L0 RefSeq (mRNA) NM_001202429 NM_016150 NM_023049 NM_001374764 RefSeq (protein) NP_001189358 NP_057234 NP_075536 NP_001361693 Location (UCSC) Chr 14: 93.93 – 93.98 Mb Chr 12: 103.29 – 103.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ankyrin repeat and SOCS box protein 2 (ASBS) is a protein that is encoded by the ASB2 gene in humans. ^[5]

The ASB2 protein belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins. It consists of an ankyrin repeat sequence and a SOCS box domain. The SOCS box plays a role in connecting suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, potentially facilitating their degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. ^[5]

References

1. ENSG00000278693 GRCh38: Ensembl release 89: ENSG00000100628, ENSG00000278693 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021200 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2".

External links

• Human ASB2 genome location and ASB2 gene details page in the UCSC Genome Browser .

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID   12076535.
• Hilton DJ, Richardson RT, Alexander WS, et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. Bibcode:1998PNAS...95..114H. doi: 10.1073/pnas.95.1.114 . PMC   18144 . PMID   9419338.
• Kile BT, Viney EM, Willson TA, et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4". Gene. 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID   11111040.
• Kile BT, Metcalf D, Mifsud S, et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC   87336 . PMID   11509662.
• Kohroki J, Fujita S, Itoh N, et al. (2001). "ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells". FEBS Lett. 505 (2): 223–8. doi: 10.1016/S0014-5793(01)02829-0 . PMID   11566180.
• Guibal FC, Moog-Lutz C, Smolewski P, et al. (2002). "ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells". J. Biol. Chem. 277 (1): 218–24. doi: 10.1074/jbc.M108476200 . PMID   11682484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID   15014966. S2CID   8594824.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Heuzé ML, Guibal FC, Banks CA, et al. (2005). "ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex". J. Biol. Chem. 280 (7): 5468–74. doi: 10.1074/jbc.M413040200 . PMID   15590664.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. doi: 10.1016/j.febslet.2005.11.016 . PMID   16325183. S2CID   7196353.