ASF1A

Last updated

ASF1A
Protein ASF1A PDB 1tey.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ASF1A , CGI-98, CIA, HSPC146, anti-silencing function 1A histone chaperone
External IDs OMIM: 609189; MGI: 1913653; HomoloGene: 8528; GeneCards: ASF1A; OMA:ASF1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014034

NM_025541

RefSeq (protein)

NP_054753

NP_079817

Location (UCSC) Chr 6: 118.89 – 118.91 Mb Chr 10: 53.47 – 53.49 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene. [5] [6] [7]

Contents

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [7]

Interactions

ASF1A has been shown to interact with TLK1, [8] [9] TLK2, [8] CHAF1B [10] and CHAF1A. [10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000111875 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019857 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
  6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
  7. 1 2 "Entrez Gene: ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae)".
  8. 1 2 Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. Bibcode:2001CBio...11.1068S. doi: 10.1016/S0960-9822(01)00298-6 . PMID   11470414. S2CID   8866062.
  9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
  10. 1 2 Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC   1084056 . PMID   11897662.

Further reading