ASF1B

ASF1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5BNX, 5BO0
Identifiers
Aliases	ASF1B , CIA-II, anti-silencing function 1B histone chaperone
External IDs	OMIM: 609190; MGI: 1914179; HomoloGene: 56797; GeneCards: ASF1B; OMA:ASF1B - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.12 Start 14,119,512 bp [1] End 14,136,613 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 C2 Start 84,682,136 bp [2] End 84,696,826 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis mucosa of transverse colon gonad testicle ventricular zone blood rectum lymph node bone marrow Top expressed in fetal liver hematopoietic progenitor cell secondary oocyte zygote tibiofemoral joint primary oocyte otic placode thymus somite condyle endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding protein binding Cellular component chromatin nucleus nucleoplasm protein-containing complex Biological process multicellular organism development DNA replication-dependent chromatin assembly nucleosome assembly cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated spermatogenesis chromatin organization blastocyst hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55723 66929 Ensembl ENSG00000105011 ENSG00000288210 ENSMUSG00000005470 UniProt Q9NVP2 Q9DAP7 RefSeq (mRNA) NM_018154 NM_024184 RefSeq (protein) NP_060624 NP_077146 Location (UCSC) Chr 19: 14.12 – 14.14 Mb Chr 8: 84.68 – 84.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. ^[7]

Interactions

ASF1B has been shown to interact with TLK2, ^{[6] [8]} CHAF1B, ^{[5] [8]} TLK1 ^{[6] [8]} and CHAF1A. ^{[5] [8]}

References

1. ENSG00000288210 GRCh38: Ensembl release 89: ENSG00000105011, ENSG00000288210 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005470 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC   1084056 . PMID   11897662.
6. Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. Bibcode:2001CBio...11.1068S. doi: 10.1016/S0960-9822(01)00298-6 . PMID   11470414. S2CID   8866062.
7. "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading

• Loyola A, Almouzni G (Mar 2004). "Histone chaperones, a supporting role in the limelight". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1677 (1–3): 3–11. doi:10.1016/j.bbaexp.2003.09.012. PMID   15020040.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Umehara T, Horikoshi M (Sep 2003). "Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis". The Journal of Biological Chemistry. 278 (37): 35660–7. doi: 10.1074/jbc.M303549200 . PMID   12842904.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G (Jan 2005). "Human Asf1 regulates the flow of S phase histones during replicational stress". Molecular Cell. 17 (2): 301–11. doi: 10.1016/j.molcel.2004.12.018 . PMID   15664198.
• Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Molecular Biology. 7: 37. doi: 10.1186/1471-2199-7-37 . PMC   1626478 . PMID   17054786.
• Hayashi R, Goto Y, Tanaka R, Oonogi K, Hisasue M, Yoshida K (Feb 2007). "Transcriptional regulation of human chromatin assembly factor ASF1". DNA and Cell Biology. 26 (2): 91–9. doi:10.1089/dna.2006.0515. PMID   17328667.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Human ASF1B genome location and ASF1B gene details page in the UCSC Genome Browser .