ASF1B

ASF1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5BNX, 5BO0
Identifiers
Aliases	ASF1B , CIA-II, anti-silencing function 1B histone chaperone
External IDs	OMIM: 609190 MGI: 1914179 HomoloGene: 56797 GeneCards: ASF1B
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,136,613 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	84,696,826 bp
RNA expression pattern
	Top expressed in
	blood; ; rectum; ; lymph node; ; bone marrow; ; ganglionic eminence; ; appendix; ; placenta; ; duodenum; ; stromal cell of endometrium; ; bone marrow cells;
	Top expressed in
	secondary oocyte; ; otic placode; ; thymus; ; somite; ; condyle; ; fossa; ; morula; ; spermatocyte; ; bone marrow; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone binding ; protein binding ;
Cellular component	chromatin ; nucleus ; nucleoplasm ; protein-containing complex ;
Biological process	multicellular organism development ; DNA replication-dependent chromatin assembly ; nucleosome assembly ; cell differentiation ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; spermatogenesis ; chromatin organization ; blastocyst hatching ;
	Sources:Amigo / QuickGO
Orthologs
	55723
	66929
	ENSG00000105011 ; ENSG00000288210
	ENSMUSG00000005470
	Q9NVP2
	Q9DAP7
	NM_018154
	NM_024184
	NP_060624
	NP_077146
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 12, 2024

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.^[5]^[6]^[7]

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.^[7]

Interactions

ASF1B has been shown to interact with TLK2,^[6]^[8] CHAF1B,^[5]^[8] TLK1 ^[6]^[8] and CHAF1A.^[5]^[8]

Related Research Articles

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Histone H3.1 is a protein that in humans is encoded by the H3C2 gene.

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.

Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene.

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High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.

Histone H2A type 2-A is a protein that in humans is encoded by the HIST2H2AA3 gene.

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.

Non-histone chromosomal protein HMG-14 is a protein that in humans is encoded by the HMGN1 gene.

Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene.

Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene.

Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene.

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.

Histone H4 is a protein that in humans is encoded by the HIST1H4F gene.

Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.

Chromatin assembly factor-1 (CAF-1) is a protein complex — including Chaf1a (p150), Chaf1b (p60), and p48 subunits in humans, or Cac1, Cac2, and Cac3, respectively, in yeast— that assembles histone tetramers onto replicating DNA during the S phase of the cell cycle.

H4K16ac is an epigenetic modification to the DNA packaging protein Histone H4. It is a mark that indicates the acetylation at the 16th lysine residue of the histone H4 protein.

References

1 2 3 ENSG00000288210 GRCh38: Ensembl release 89: ENSG00000105011, ENSG00000288210 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005470 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056 . PMID 11897662.
1 2 3 Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. Bibcode:2001CBio...11.1068S. doi: 10.1016/S0960-9822(01)00298-6 . PMID 11470414. S2CID 8866062.
1 2 "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".
1 2 3 4 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

External links

Human ASF1B genome location and ASF1B gene details page in the UCSC Genome Browser .

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
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[refGRCh38Ensembl-1] 1 2 3 ENSG00000288210 GRCh38: Ensembl release 89: ENSG00000105011, ENSG00000288210 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005470 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11897662-5] 1 2 3 Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056 . PMID 11897662.

[pmid11470414-6] 1 2 3 Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. Bibcode:2001CBio...11.1068S. doi: 10.1016/S0960-9822(01)00298-6 . PMID 11470414. S2CID 8866062.

[entrez-7] 1 2 "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".

[pmid17353931-8] 1 2 3 4 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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