ATG9B

ATG9B
Identifiers
Aliases	ATG9B , APG9L2, NOS3AS, SONE, autophagy related 9B
External IDs	OMIM: 612205 MGI: 2685420 HomoloGene: 72638 GeneCards: ATG9B
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,024,499 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,597,141 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; right uterine tube; ; anterior pituitary; ; amniotic fluid; ; bronchial epithelial cell; ; sperm; ; vagina; ; spleen; ; nucleus accumbens; ; hypothalamus;
	Top expressed in
	lip; ; esophagus; ; skin of back; ; hair follicle; ; belly cord; ; morula; ; supraoptic nucleus; ; skin of abdomen; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus;
	More reference expression data
	n/a
Orthologs
	285973
	213948
	ENSG00000181652
	ENSMUSG00000038295
	Q674R7
	Q6EBV9
	NM_001317056
	NM_001002897
	NP_001303985 ; NP_775952
	NP_001002897
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 02, 2023

Autophagy related 9B is a protein that in humans is encoded by the ATG9B gene.^[5]

Function

This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the post-transcriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants.

Related Research Articles

Complement component 6 is a protein that in humans is encoded by the C6 gene.

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene.

<span class="mw-page-title-main">CCL8</span> Mammalian protein found in Homo sapiens

Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.

Prostaglandin-I synthase also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This enzyme belongs to the family of cytochrome P450 isomerases.

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.

<span class="mw-page-title-main">L-xylulose reductase</span> Enzyme

Dicarbonyl/L-xylulose reductase, also known as carbonyl reductase II, is an enzyme that in human is encoded by the DCXR gene located on chromosome 17.

The interleukin-1 receptor antagonist protein (IL-1RN) is a protein that in humans is encoded by the IL1RN gene.

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.

Zinc transporter ZIP10, also known as solute carrier family 39 member 10, is a protein that in humans is encoded by the SLC39A10 gene. ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters, and have 14 members in the human genome: ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13 and ZIP14.

Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.

LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers.

Transmembrane and coiled-coil domain 6, TMCO6, is a protein that in humans is encoded by the TMCO6 gene with aliases of PRO1580, HQ1580 or FLJ39769.1.

Eugenia E. “Jeanne” Calle (1952–2009) was an American cancer epidemiologist.

B-cell CLL/lymphoma 7 protein family member A is a protein that in humans is encoded by the BCL7A gene.

Pacer is a protein that in humans is encoded by the RUBCNL gene. Pacer has been shown to increase cellular autophagy through regulation of PI3KC3.

Pecanex homolog 3 is a protein that in humans is encoded by the PCNX3 gene.

Solute carrier family 30 member 10 is a protein that in humans is encoded by the SLC30A10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000181652 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038295 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Autophagy related 9B" . Retrieved 2017-06-12.

Yamada T, Carson AR, Caniggia I, Umebayashi K, Yoshimori T, Nakabayashi K, Scherer SW (2005). "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast". J. Biol. Chem. 280 (18): 18283–90. doi: 10.1074/jbc.M413957200 . PMID 15755735.
Kang MR, Kim MS, Oh JE, Kim YR, Song SY, Kim SS, Ahn CH, Yoo NJ, Lee SH (2009). "Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability". J. Pathol. 217 (5): 702–6. doi:10.1002/path.2509. PMID 19197948. S2CID 20532583.
Han X, Zheng T, Lan Q, Zhang Y, Kilfoy BA, Qin Q, Rothman N, Zahm SH, Holford TR, Leaderer B, Zhang Y (2009). "Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1429–38. doi:10.1158/1055-9965.EPI-09-0001. PMC 2965355 . PMID 19423521.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ (2009). "Common variation in genes related to innate immunity and risk of adult glioma". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. doi:10.1158/1055-9965.EPI-08-1041. PMC 2771723 . PMID 19423540.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC 2810344 . PMID 19948975.
Webber JL, Tooze SA (2010). "New insights into the function of Atg9". FEBS Lett. 584 (7): 1319–26. doi:10.1016/j.febslet.2010.01.020. PMID 20083107. S2CID 46372298.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD (2010). "Risk of meningioma and common variation in genes related to innate immunity". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. doi:10.1158/1055-9965.EPI-09-1151. PMC 3169167 . PMID 20406964.
Ban HJ, Heo JY, Oh KS, Park KJ (2010). "Identification of type 2 diabetes-associated combination of SNPs using support vector machine". BMC Genet. 11: 26. doi: 10.1186/1471-2156-11-26 . PMC 2875201 . PMID 20416077.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000181652 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038295 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Autophagy related 9B" . Retrieved 2017-06-12.

[1]

[2]

[3]

[4]

[5]

ATG9B

Contents

Function

Related Research Articles

References

Further reading