ATP5O

ATP5PO
Identifiers
Aliases	ATP5PO , ATPO, OSCP, HMC08D05, ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit, ATP synthase peripheral stalk subunit OSCP, ATP5O
External IDs	OMIM: 600828 MGI: 106341 HomoloGene: 1283 GeneCards: ATP5PO
Gene location (Human)
Chr.	Chromosome 21 (human)
End	33,915,814 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	91,931,687 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• proton-transporting ATP synthase activity, rotational mechanism ; • GO:0022891 transmembrane transporter activity ; • transporter activity ; • ATPase activity ; • GO:0001948 protein binding ; • drug binding ;
Cellular component	• mitochondrial proton-transporting ATP synthase complex ; • membrane ; • cell membrane ; • mitochondrion ; • mitochondrial inner membrane ; • extracellular exosome ; • nucleus ; • GO:0005578 extracellular matrix ;
Biological process	• mitochondrial ATP synthesis coupled proton transport ; • ion transport ; • ATP synthesis coupled proton transport ; • ATP biosynthetic process ; • cristae formation ; • transport ; • proton transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	539
	28080
	ENSG00000241837
	ENSMUSG00000022956
	P48047
	Q9DB20
	NM_001697
	NM_138597
	NP_001688
	NP_613063
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2021

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.^[5]

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. ^[5]

Related Research Articles

ATP synthase F1 subunit alpha, mitochondrial is an enzyme that in humans is encoded by the ATP5F1A gene.

ATP synthase-coupling factor 6, mitochondrial is an enzyme subunit that in humans is encoded by the ATP5PF gene.

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

The ATP5MC1 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

The ATP5MF gene encodes the ATP synthase subunit f, mitochondrial enzyme in humans.

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene.

The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5PB gene.

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.

The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5ME gene.

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.

ATP synthase subunit delta, mitochondrial, also known as ATP synthase F1 subunit delta or F-ATPase delta subunit is an enzyme that in humans is encoded by the ATP5F1D gene. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation.

Probable cation-transporting ATPase 13A3 is an enzyme that in humans is encoded by the ATP13A3 gene.

The ATP5MC3 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.

28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene.

ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene.

39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene.

ATP synthase mitochondrial F1 complex assembly factor 1, also known as ATP11 homolog, is a protein that in humans is encoded by the ATPAF1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000241837 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022956 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ATP5PO ATP synthase peripheral stalk subunit OSCP".

External links

Human ATP5PO genome location and ATP5PO gene details page in the UCSC Genome Browser .

Chen H, Morris MA, Rossier C, et al. (1996). "Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2". Genomics. 28 (3): 470–6. doi:10.1006/geno.1995.1176. PMID 7490082.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID 10830953.
Aggeler R, Coons J, Taylor SW, et al. (2002). "A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies". J. Biol. Chem. 277 (37): 33906–12. doi: 10.1074/jbc.M204538200 . PMID 12110673.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Johnson KM, Chen X, Boitano A, et al. (2005). "Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423". Chem. Biol. 12 (4): 485–96. doi: 10.1016/j.chembiol.2005.02.012 . PMID 15850986.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000241837 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022956 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ATP5PO ATP synthase peripheral stalk subunit OSCP".

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ATP5O

Contents

Related Research Articles

References

External links

Further reading