Afamin

AFM
Identifiers
Aliases	AFM , ALB2, ALBA, ALF, afamin
External IDs	OMIM: 104145 MGI: 2429409 HomoloGene: 881 GeneCards: AFM
Gene location (Human)
Chr.	Chromosome 4 (human)
End	73,504,001 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	90,701,402 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; kidney; ; glomerulus; ; metanephric glomerulus; ; tibialis anterior muscle; ; renal medulla; ; fundus; ; body of pancreas; ; body of stomach;
	Top expressed in
	left lobe of liver; ; kidney; ; proximal straight tubule; ; renal pelvis; ; renal calyx; ; sexually immature organism; ; gallbladder; ; ureter; ; medullary collecting duct; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	vitamin E binding ; protein binding ;
Cellular component	extracellular region ; blood microparticle ; extracellular exosome ; extracellular space ;
Biological process	vitamin transport ; transport ; protein transport ; protein stabilization ; protein transport within extracellular region ;
	Sources:Amigo / QuickGO
Orthologs
	173
	280662
	ENSG00000079557
	ENSMUSG00000029369
	P43652
	O89020
	NM_001133
	NM_145146
	NP_001124
	NP_660128
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 28, 2023

Afamin is a protein that in humans is encoded by the AFM gene.^[5]^[6]

Function

This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000079557 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029369 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM (Aug 1994). "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family". J Biol Chem. 269 (27): 18149–54. doi: 10.1016/S0021-9258(17)32429-8 . PMID 7517938.
1 2 "Entrez Gene: AFM afamin".

External links

Human AFM genome location and AFM gene details page in the UCSC Genome Browser .

Noppe M, Lowenthal A, Karcher D, Gheuens J (1979). "A two-site immunoradiometric assay for the determination of alpha-albumin". J. Immunol. Methods. 27 (1): 75–81. doi:10.1016/0022-1759(79)90240-0. PMID 37276.
Hansson E, Rönnbäck L, Lowenthal A, Noppe M (1985). "Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis". Brain Res. 353 (2): 175–85. doi:10.1016/0165-3806(85)90206-8. PMID 4041902.
Lowenthal A, Flament-Durand J, Karcher D, Noppe M, Brion JP (1982). "Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland". J. Neurochem. 38 (3): 863–5. doi:10.1111/j.1471-4159.1982.tb08714.x. PMID 7035619. S2CID 40660858.
Allard D, Gilbert S, Lamontagne A, Hamel D, Bélanger L (1995). "Identification of rat alpha-albumin and cDNA cloning of its human ortholog". Gene. 153 (2): 287–8. doi:10.1016/0378-1119(94)00745-E. PMID 7875606.
Nishio H, Heiskanen M, Palotie A, Bélanger L, Dugaiczyk A (1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription". J. Mol. Biol. 259 (1): 113–9. doi:10.1006/jmbi.1996.0306. PMID 8648639.
Nishio H, Dugaiczyk A (1996). "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7557–61. Bibcode:1996PNAS...93.7557N. doi: 10.1073/pnas.93.15.7557 . PMC 38784 . PMID 8755513.
Song YH, Naumova AK, Liebhaber SA, Cooke NE (1999). "Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster". Genome Res. 9 (6): 581–7. doi:10.1101/gr.9.6.581. PMC 310762 . PMID 10400926.
Khan MA, Kumar Y, Tayyab S (2003). "Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin". Int. J. Biol. Macromol. 30 (3–4): 171–8. doi:10.1016/S0141-8130(02)00017-X. PMID 12063119.
Voegele AF, Jerković L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H (2003). "Characterization of the vitamin E-binding properties of human plasma afamin". Biochemistry. 41 (49): 14532–8. doi:10.1021/bi026513v. PMID 12463752.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718. S2CID 29261009.
Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H (2005). "Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression". J. Proteome Res. 4 (3): 889–99. CiteSeerX 10.1.1.706.313 . doi:10.1021/pr0500105. PMID 15952736.
Hu Y, Malone JP, Fagan AM, Townsend RR, Holtzman DM (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid". Mol. Cell. Proteomics. 4 (12): 2000–9. doi: 10.1074/mcp.M500207-MCP200 . PMID 16199891.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943 . PMID 16335952.
Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000079557 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029369 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7517938-5] Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM (Aug 1994). "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family". J Biol Chem. 269 (27): 18149–54. doi: 10.1016/S0021-9258(17)32429-8 . PMID 7517938.

[entrez-6] 1 2 "Entrez Gene: AFM afamin".

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Afamin

Contents

Function

Related Research Articles

References

External links

Further reading