Alexander Silberman Institute of Life Sciences

Last updated
Alexander Silberman Institute of Life Sciences
PikiWiki Israel 3992 givat ram campus.jpg
TypeResearch Institute
Established1925
Parent institution
The Hebrew University of Jerusalem
Chairperson Prof. Guy Bloch
Academic staff
75
Students900
Undergraduates 600
Location
Jerusalem
,
Israel
LanguageHebrew & English
Website https://www.bio.huji.ac.il/en

The Alexander Silberman Institute of Life Sciences (AS-ILS) at the Hebrew University of Jerusalem is the oldest life sciences research institute in Israel. It is part of the Faculty of Sciences, and is located in the Edmond J. Safra Campus (Givat Ram) in Jerusalem.

Contents

History

The origins of the institute date back to 1925, the year that the Hebrew University was founded, [1] when the Department of Botany was formed as part of a research unit called "The Institute for Studying the Natural History of the Land of Israel". Among the founding researchers were Profs. Otto Warburg, [2] Alexander Eig, [3] Michael Zohary [4] and Naomi Feinbrun-Dothan. [5] During the first years of the department, several large-scale projects that continue to this day have been started off, including the establishment of the Herbarium Collection, [6] today part of Israel's Natural History Collections, [7] and the establishment of the National Botanic Garden of Israel at Mount Scopus, which was the first of its kind in the Middle East.

In 1928, Prof. Simon Bodenheimer joined the nascent institute and established the Department of Zoology, leading the institute to probe into new scientific fields. [8]

Research activities at both departments (and at the Hebrew University in general) were diminished in 1948 during the War of Independence, and were brought to a complete stop following the Hadassah medical convoy massacre. Activity in both departments was renewed after the war, in April 1949. [1]

Notable achievements

Throughout the years AS-ILS members have conducted basic research as well as applied science in the fields of biomedicine, biotechnology and agriculture at multiple levels of organization, from molecular mechanism in cells, through processes within the whole organism, and to studies at the population level. AS-ILS members have been associated with several discoveries:

Study Programs

The institute offers a number of undergraduate programs, including a single major program, joint dual major programs, supplementary units, and a number of excellence programs. [39] [40]

Related Research Articles

<span class="mw-page-title-main">Germline</span> Population of a multicellular organisms cells that pass on their genetic material to the progeny

In biology and genetics, the germline is the population of a multicellular organism's cells that develop into germ cells. In other words, they are the cells that form gametes, which can come together to form a zygote. They differentiate in the gonads from primordial germ cells into gametogonia, which develop into gametocytes, which develop into the final gametes. This process is known as gametogenesis.

<span class="mw-page-title-main">Embryoid body</span> Three-dimensional aggregate of pluripotent stem cells

Embryoid bodies (EBs) are three-dimensional aggregates formed by pluripotent stem cells. These include embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC)

Transforming growth factor is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

Marlene Belfort is an American biochemist known for her research on the factors that interrupt genes and proteins. She is a fellow of the American Academy of Arts and Sciences and has been admitted to the United States National Academy of Sciences.

Douglas A. Melton is an American medical researcher who is the Xander University Professor at Harvard University, and was an investigator at the Howard Hughes Medical Institute until 2022. Melton serves as the co-director of the Harvard Stem Cell Institute and was the first co-chairman of the Harvard University Department of Stem Cell and Regenerative Biology. Melton is the founder of several biotech companies including Gilead Sciences, Ontogeny, iPierian, and Semma Therapeutics. Melton holds membership in the National Academy of the Sciences, the American Academy of Arts and Sciences, and is a founding member of the International Society for Stem Cell Research.

<span class="mw-page-title-main">Homeobox protein CDX-2</span> Protein-coding gene in the species Homo sapiens

Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX-2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, playing an essential role in the development and function of the digestive system. CDX2 is part of the ParaHox gene cluster, a group of three highly conserved developmental genes present in most vertebrate species. Together with CDX1 and CDX4, CDX2 is one of three caudal-related genes in the human genome.

<span class="mw-page-title-main">ANAPC5</span> Protein-coding gene in the species Homo sapiens

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.

Photoactivatable fluorescent proteins (PAFPs) is a type of fluorescent protein that exhibit fluorescence that can be modified by a light-induced chemical reaction.

<span class="mw-page-title-main">Jared Diamond bibliography</span> Author bibliography

Jared Diamond is an American scientist and author. Trained in physiology, and having published on ecology, anthropology, and linguistics, Diamond's work is known for drawing from a variety of fields. He is currently professor of geography at the University of California, Los Angeles (UCLA). Among his awards are a Pulitzer Prize and an International Cosmos Prize. Diamond splits his time between teaching at UCLA, researching birds of the Pacific islands, writing books about human societies, and promoting sustainable ecological practices. He formerly had a secondary career path in physiology and biophysics.

Margaret Buckingham, is a British developmental biologist working in the fields of myogenesis and cardiogenesis. She is an honorary professor at the Pasteur Institute in Paris and emeritus director in the Centre national de la recherche scientifique (CNRS). She is a member of the European Molecular Biology Organization, the Academia Europaea and the French Academy of Sciences.

Jamey Marth is a molecular and cellular biologist. He is currently on the faculty of the SBP Medical Discovery Institute in La Jolla, California where he is Director of the Immunity and Pathogenesis program.

Tripartite motif-containing 14 is a protein encoded by the TRIM14 gene in the human genome. It belongs to the TRIM family of proteins which contain the TRIM motif on the N-terminus. TRIM14 lacks the RING domain within the motif and therefore it loses the function of E3 ubiquitin ligase in eukaryotic cells. Instead, the PRYSPRY domain on the C-terminus allows TRIM14 to be categorized into an evolutionarily younger group of TRIM proteins which are involved in the regulation of innate immunity. TRIM 14 is localized in both the cytoplasm and the cell nucleus.

<span class="mw-page-title-main">Frank Ruddle</span> American cell and developmental biologist (1929–2013)

Francis Hugh Ruddle (1929–2013) was an American cell and developmental biologist who was the Sterling Professor at Yale University. Ruddle was an early visionary of the Human Genome Project and created the first genetically modified mouse. He was a pioneer in both human and mouse genetics.

<span class="mw-page-title-main">Hanah Margalit</span>

Hanah Margalit is a Professor in the faculty of medicine at the Hebrew University of Jerusalem. Her research combines bioinformatics, computational biology and systems biology, specifically in the fields of gene regulation in bacteria and eukaryotes.

Promiscuous gene expression (PGE), formerly referred to as ectopic expression, is a process specific to the thymus that plays a pivotal role in the establishment of central tolerance. This phenomenon enables generation of self-antigens, so called tissue-restricted antigens (TRAs), which are in the body expressed only by one or few specific tissues. These antigens are represented for example by insulin from the pancreas or defensins from the gastrointestinal tract. Antigen-presenting cells (APCs) of the thymus, namely medullary thymic epithelial cells (mTECs), dendritic cells (DCs) and B cells are capable to present peptides derived from TRAs to developing T cells and hereby test, whether their T cell receptors (TCRs) engage self entities and therefore their occurrence in the body can potentially lead to the development of autoimmune disease. In that case, thymic APCs either induce apoptosis in these autoreactive T cells or they deviate them to become T regulatory cells, which suppress self-reactive T cells in the body that escaped negative selection in the thymus. Thus, PGE is crucial for tissues protection against autoimmunity.

<span class="mw-page-title-main">David Suter (biologist)</span> David Suter, Swiss cell biologist

David Suter is a Swiss physician and molecular and cell biologist. His research focuses on quantitative approaches to study gene expression and developmental cell fate decisions. He is currently a professor at EPFL, where he heads the Suter Lab at the Institute of Bioengineering of the School of Life Sciences.

Paula Veronica Welander is a microbiologist and professor at Stanford University who is known for her research using lipid biomarkers to investigate how life evolved on Earth.

Eran Meshorer is an Israeli scientist, professor of epigenetics and stem cells at the Alexander Silberman Institute of Life Sciences, and the Edmond and Lily Safra Center for Brain Sciences, the Hebrew University of Jerusalem. Meshorer is the Arthur Gutterman Chair for Stem Cell Research.

Nissim Benvenisty is Professor of Genetics, the Herbert Cohn Chair in Cancer Research and the Director of “The Azrieli Center for Stem Cells and Genetic Research” at the Alexander Silberman Institute of Life Sciences, Hebrew University.

Brandon Stuart Gaut is an American evolutionary biologist and geneticist who works as a Distinguished Professor of Ecology and Evolutionary Biology at the University of California, Irvine.

References

  1. 1 2 "The Hebrew University of Jerusalem". www.jewishvirtuallibrary.org.
  2. "Otto Warburg (botanist)". JSTOR Global Plants.
  3. "Alexander Eig". JSTOR Global Plants.
  4. "Michael Zohary". JSTOR Global Plants.
  5. "Naomi Feinbrun-Dothan". Jewish Women's Archive.
  6. "Something went wrong..." en-nnhc.huji.ac.il.
  7. "The National Natural History Collections". en-nnhc.huji.ac.il.
  8. Harpaz, I. (1984). "Frederick Simon Bodenheimer (1897–1959): Idealist, Scholar, Scientist". Annual Review of Entomology. 29: 1–24. doi:10.1146/annurev.en.29.010184.000245. S2CID   86230193.
  9. Eig, Alexander (1926). A contribution to the knowledge of the flora of Palestine (1st ed.). The Zionist organisation and the Hebrew Univ, Tel-Aviv.
  10. GOLDSCHMIDT, ELISABETH; RONEN, AMIRAM; RONEN, ILANA (1960). "Changing marriage systems in the Jewish communities of Israel*". Annals of Human Genetics. 24 (3): 191–204. doi:10.1111/j.1469-1809.1960.tb01732.x. ISSN   0003-4800. PMID   13850739.
  11. Goldschmidt, E.; Cohen, T. (1964-01-01). "Inter-ethnic Mixture among the Communities of Israel". Cold Spring Harbor Symposia on Quantitative Biology. 29: 115–120. doi:10.1101/sqb.1964.029.01.016. ISSN   0091-7451. PMID   14278459.
  12. Horowitz, A.; Cohen, T.; Goldschmidt, E.; Levene, C. (1966). "Thalassaemia Types among Kurdish Jews in Israel". British Journal of Haematology. 12 (5): 555–568. doi:10.1111/j.1365-2141.1966.tb00138.x. ISSN   0007-1048. PMID   5915052.
  13. Zohary, Michael, ed. (1981). Flora Palaestina. Text: 1. Equisetaceae to moringaceae / by Michael Zohary (2. print ed.). Jerusalem: Israel Acad. of Sciences and Human. ISBN   978-965-208-001-1.
  14. Levitzki, Alexander; Koshland, D. E. (1969). "Negative Cooperativity in Regulatory Enzymes". Proceedings of the National Academy of Sciences. 62 (4): 1121–1128. Bibcode:1969PNAS...62.1121L. doi: 10.1073/pnas.62.4.1121 . ISSN   0027-8424. PMC   223623 . PMID   5256410.
  15. Cassel, Dan; Selinger, Zvi (August 1977). "Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site". Proceedings of the National Academy of Sciences. 74 (8): 3307–3311. Bibcode:1977PNAS...74.3307C. doi: 10.1073/pnas.74.8.3307 . ISSN   0027-8424. PMC   431542 . PMID   198781.
  16. Huez, G.; Marbaix, G.; Burny, A.; Hubert, E.; Leclercq, M.; Cleuter, Y.; Chantrenne, H.; Soreq, H.; Littauer, U. Z. (March 1977). "Degradation of deadenylated rabbit α-globin mRNA in Xenopus oocytes is associated with its translation". Nature. 266 (5601): 473–474. Bibcode:1977Natur.266..473H. doi:10.1038/266473a0. ISSN   0028-0836. PMID   558522.
  17. Atlas, Daphne; Levitzki, Alexander (1978). "Tentative identification of β-adrenoreceptor subunits". Nature. 272 (5651): 370–371. Bibcode:1978Natur.272..370A. doi:10.1038/272370a0. ISSN   0028-0836. PMID   204872.
  18. Cassel, D; Selinger, Z (September 1978). "Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP". Proceedings of the National Academy of Sciences. 75 (9): 4155–4159. Bibcode:1978PNAS...75.4155C. doi: 10.1073/pnas.75.9.4155 . ISSN   0027-8424. PMC   336070 . PMID   212737.
  19. Zohary, Daniel; Hopf, Maria; Weiss, Ehud (2012). Domestication of plants in the Old World: the origin and spread of domesticated plants in Southwest Asia, Europe, and the Mediterranean Basin (Fourth ed.). Oxford: Oxford University Press. ISBN   978-0-19-954906-1.
  20. Goldberg, E B; Arbel, T; Chen, J; Karpel, R; Mackie, G A; Schuldiner, S; Padan, E (May 1987). "Characterization of a Na+/H+ antiporter gene of Escherichia coli". Proceedings of the National Academy of Sciences. 84 (9): 2615–2619. doi: 10.1073/pnas.84.9.2615 . ISSN   0027-8424. PMC   304708 . PMID   3033655.
  21. Yaish, Pnina; Gazit, Aviv; Gilon, Chaim; Levitzki, Alexander (1988-11-11). "Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors". Science. 242 (4880): 933–935. Bibcode:1988Sci...242..933Y. doi:10.1126/science.3263702. ISSN   0036-8075. PMID   3263702.
  22. Kassir, Yona; Granot, David; Simchen, Giora (March 1988). "IME1, a positive regulator gene of meiosis in S. cerevisiae". Cell. 52 (6): 853–862. doi:10.1016/0092-8674(88)90427-8. PMID   3280136.
  23. Kerem, Bat-Sheva; Rommens, Johanna M.; Buchanan, Janet A.; Markiewicz, Danuta; Cox, Tara K.; Chakravarti, Aravinda; Buchwald, Manuel; Tsui, Lap-Chee (1989-09-08). "Identification of the Cystic Fibrosis Gene: Genetic Analysis". Science. 245 (4922): 1073–1080. Bibcode:1989Sci...245.1073K. doi:10.1126/science.2570460. ISSN   0036-8075. PMID   2570460.
  24. Zenvirth, D.; Arbel, T.; Sherman, A.; Goldway, M.; Klein, S.; Simchen, G. (September 1992). "Multiple sites for double-strand breaks in whole meiotic chromosomes of Saccharomyces cerevisiae". The EMBO Journal. 11 (9): 3441–3447. doi:10.1002/j.1460-2075.1992.tb05423.x. PMC   556879 . PMID   1324174.
  25. Kaufer, Daniela; Friedman, Alon; Seidman, Shlomo; Soreq, Hermona (1998-05-28). "Acute stress facilitates long-lasting changes in cholinergic gene expression". Nature. 393 (6683): 373–377. Bibcode:1998Natur.393..373K. doi:10.1038/30741. ISSN   0028-0836. PMID   9620801. (Erratum:  doi:10.1038/nature16180, PMID   26605528 . If the erratum has been checked and does not affect the cited material, please replace {{ erratum |...}} with {{ erratum |...|checked=yes}}.)
  26. Eiges, Rachel; Schuldiner, Maya; Drukker, Micha; Yanuka, Ofra; Itskovitz-Eldor, Joseph; Benvenisty, Nissim (April 2001). "Establishment of human embryonic stem cell-transfected clones carrying a marker for undifferentiated cells". Current Biology. 11 (7): 514–518. Bibcode:2001CBio...11..514E. doi:10.1016/S0960-9822(01)00144-0. PMID   11413002.
  27. Avior, Yishai; Sagi, Ido; Benvenisty, Nissim (March 2016). "Pluripotent stem cells in disease modelling and drug discovery". Nature Reviews Molecular Cell Biology. 17 (3): 170–182. doi:10.1038/nrm.2015.27. ISSN   1471-0072. PMID   26818440.
  28. Drukker, Micha; Katz, Gil; Urbach, Achia; Schuldiner, Maya; Markel, Gal; Itskovitz-Eldor, Joseph; Reubinoff, Benjamin; Mandelboim, Ofer; Benvenisty, Nissim (2002-07-23). "Characterization of the expression of MHC proteins in human embryonic stem cells". Proceedings of the National Academy of Sciences. 99 (15): 9864–9869. Bibcode:2002PNAS...99.9864D. doi: 10.1073/pnas.142298299 . ISSN   0027-8424. PMC   125045 . PMID   12114532.
  29. Blum, Barak; Bar-Nur, Ori; Golan-Lev, Tamar; Benvenisty, Nissim (March 2009). "The anti-apoptotic gene survivin contributes to teratoma formation by human embryonic stem cells". Nature Biotechnology. 27 (3): 281–287. doi:10.1038/nbt.1527. ISSN   1087-0156. PMID   19252483.
  30. Tal, Nir; Schuldiner, Shimon (2009-06-02). "A coordinated network of transporters with overlapping specificities provides a robust survival strategy". Proceedings of the National Academy of Sciences. 106 (22): 9051–9056. Bibcode:2009PNAS..106.9051T. doi: 10.1073/pnas.0902400106 . ISSN   0027-8424. PMC   2690002 . PMID   19451626.
  31. Bester, Assaf C.; Roniger, Maayan; Oren, Yifat S.; Im, Michael M.; Sarni, Dan; Chaoat, Malka; Bensimon, Aaron; Zamir, Gideon; Shewach, Donna S.; Kerem, Batsheva (April 2011). "Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development". Cell. 145 (3): 435–446. doi:10.1016/j.cell.2011.03.044. PMC   3740329 . PMID   21529715.
  32. Nakamura, Kensuke; Inokuchi, Ryota; Doi, Kent; Fukuda, Tatsuma; Tokunaga, Kurato; Nakajima, Susumu; Noiri, Eisei; Yahagi, Naoki (2014). "Septic Ketoacidosis". Internal Medicine. 53 (10): 1071–1073. doi: 10.2169/internalmedicine.53.1791 . ISSN   0918-2918. PMID   24827487.
  33. Gokhman, David; Lavi, Eitan; Prüfer, Kay; Fraga, Mario F.; Riancho, José A.; Kelso, Janet; Pääbo, Svante; Meshorer, Eran; Carmel, Liran (2014-05-02). "Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan". Science. 344 (6183): 523–527. Bibcode:2014Sci...344..523G. doi:10.1126/science.1250368. ISSN   0036-8075. PMID   24786081.
  34. Sagi, Ido; Chia, Gloryn; Golan-Lev, Tamar; Peretz, Mordecai; Weissbein, Uri; Sui, Lina; Sauer, Mark V.; Yanuka, Ofra; Egli, Dieter; Benvenisty, Nissim (2016-04-07). "Derivation and differentiation of haploid human embryonic stem cells". Nature. 532 (7597): 107–111. Bibcode:2016Natur.532..107S. doi:10.1038/nature17408. ISSN   0028-0836. PMID   26982723.
  35. Yilmaz, Atilgan; Peretz, Mordecai; Aharony, Aviram; Sagi, Ido; Benvenisty, Nissim (May 2018). "Defining essential genes for human pluripotent stem cells by CRISPR–Cas9 screening in haploid cells". Nature Cell Biology. 20 (5): 610–619. doi:10.1038/s41556-018-0088-1. ISSN   1465-7392. PMID   29662178.
  36. Bar, Shiran; Vershkov, Dan; Keshet, Gal; Lezmi, Elyad; Meller, Naama; Yilmaz, Atilgan; Yanuka, Ofra; Nissim-Rafinia, Malka; Meshorer, Eran; Eldar-Geva, Talia; Benvenisty, Nissim (2021-11-18). "Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells". Nature Communications. 12 (1): 6718. Bibcode:2021NatCo..12.6718B. doi:10.1038/s41467-021-26949-7. ISSN   2041-1723. PMC   8602306 . PMID   34795250.
  37. Gokhman, David; Mishol, Nadav; de Manuel, Marc; de Juan, David; Shuqrun, Jonathan; Meshorer, Eran; Marques-Bonet, Tomas; Rak, Yoel; Carmel, Liran (September 2019). "Reconstructing Denisovan Anatomy Using DNA Methylation Maps". Cell. 179 (1): 180–192.e10. doi:10.1016/j.cell.2019.08.035. PMID   31539495.
  38. Winek, Katarzyna; Lobentanzer, Sebastian; Nadorp, Bettina; Dubnov, Serafima; Dames, Claudia; Jagdmann, Sandra; Moshitzky, Gilli; Hotter, Benjamin; Meisel, Christian; Greenberg, David S.; Shifman, Sagiv; Klein, Jochen; Shenhar-Tsarfaty, Shani; Meisel, Andreas; Soreq, Hermona (2020-12-22). "Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade". Proceedings of the National Academy of Sciences. 117 (51): 32606–32616. Bibcode:2020PNAS..11732606W. doi: 10.1073/pnas.2013542117 . ISSN   0027-8424. PMC   7768686 . PMID   33288717.
  39. "מידע על החוג". catalog.huji.ac.il.
  40. "מידע על החוג". catalog.huji.ac.il.