The Alfred P. Sloan Jr. Prize was a $250,000 award given by the General Motors Cancer Research Foundation for outstanding oncological research. [1] [2]
The prize was awarded annually from 1979 to 2005. Of the winners, 15 out of 37 have gone on to win either a Nobel Prize in Physiology or Medicine or a Nobel Prize in Chemistry.
in 2006, due to budget constraints, the Alfred P. Sloan Jr. prize, the Charles K. Kettering prize, and the Charles S. Mott Prize were consolidated into a single General Motors Cancer Research Award which also had a value of $250,000. [3] The first and only winner of the General Motors Cancer Research Award was Napoleone Ferrara. [4]
After 2006 no more prizes were awarded.[ citation needed ]
The Nobel Prizes are five separate prizes awarded to those who, during the preceding year, have conferred the greatest benefit to humankind, as established by the 1895 will of Swedish chemist, engineer, and industrialist Alfred Nobel, in the year before he died. Prizes were first awarded in 1901 by the Nobel Foundation. Nobel's will indicated that the awards should be granted in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. A sixth prize for Economic Sciences, endowed by Sweden's central bank, Sveriges Riksbank, and first presented in 1969, is also frequently included, as it is also administered by the Nobel Foundation. The Nobel Prizes are widely regarded as the most prestigious awards available in their respective fields.
Alfred Pritchard Sloan Jr. was an American business executive in the automotive industry. He was a long-time president, chairman and CEO of General Motors Corporation. Sloan, first as a senior executive and later as the head of the organization, helped GM grow from the 1920s through the 1950s, decades when concepts such as the annual model change, brand architecture, industrial engineering, automotive design (styling), and planned obsolescence transformed the industry, and when the industry changed lifestyles and the built environment in America and throughout the world.
Charles Franklin Kettering sometimes known as Charles Fredrick Kettering was an American inventor, engineer, businessman, and the holder of 186 patents. He was a founder of Delco, and was head of research at General Motors from 1920 to 1947. Among his most widely used automotive developments were the electrical starting motor and leaded gasoline. In association with the DuPont Chemical Company, he was also responsible for the invention of Freon refrigerant for refrigeration and air conditioning systems. At DuPont he also was responsible for the development of Duco lacquers and enamels, the first practical colored paints for mass-produced automobiles. While working with the Dayton-Wright Company he developed the "Bug" aerial torpedo, considered the world's first aerial missile. He led the advancement of practical, lightweight two-stroke diesel engines, revolutionizing the locomotive and heavy equipment industries. In 1927, he founded the Kettering Foundation, a non-partisan research foundation, and was featured on the cover of Time magazine in January 1933.
Harold Eliot Varmus is an American Nobel Prize-winning scientist. He is currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine and a senior associate at the New York Genome Center.
Memorial Sloan Kettering Cancer Center is a cancer treatment and research institution in Manhattan in New York City. It was founded in 1884 as the New York Cancer Hospital. MSKCC is one of 72 National Cancer Institute-designated Comprehensive Cancer Centers. It had already been renamed and relocated, to its present site, when the Sloan-Kettering Institute for Cancer Research was founded in 1945, and built adjacent to the hospital. The two medical entities formally coordinated their operations in 1960, and formally merged as a single entity in 1980. Its main campus is located at 1275 York Avenue between 67th and 68th Streets in Manhattan.
James Edward Rothman is an American biochemist. He is the Fergus F. Wallace Professor of Biomedical Sciences at Yale University, the Chairman of the Department of Cell Biology at Yale School of Medicine, and the Director of the Nanobiology Institute at the Yale West Campus. Rothman also concurrently serves as adjunct professor of physiology and cellular biophysics at Columbia University and a research professor at the UCL Queen Square Institute of Neurology, University College London.
Edward Donnall "Don" Thomas was an American physician, professor emeritus at the University of Washington, and director emeritus of the clinical research division at the Fred Hutchinson Cancer Research Center. In 1990 he shared the Nobel Prize in Physiology or Medicine with Joseph E. Murray for the development of cell and organ transplantation. Thomas and his wife and research partner Dottie Thomas developed bone marrow transplantation as a treatment for leukemia.
The Charles F. Kettering Prize was a US$250,000 award given by the General Motors Cancer Research Foundation for the most outstanding recent contribution to the diagnosis or treatment of cancer.
Oliver Smithies was a British-American geneticist and physical biochemist. He is known for introducing starch as a medium for gel electrophoresis in 1955, and for the discovery, simultaneously with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previously used, and the technique behind gene targeting and knockout mice. He received the Nobel Prize in Physiology or Medicine in 2007 for his genetics work.
Delco Electronics Corporation was the automotive electronics design and manufacturing subsidiary of General Motors based in Kokomo, Indiana, that manufactured Delco Automobile radios and other electric products found in GM cars. In 1972, General Motors merged it with the AC Electronics division and it continued to operate as part of the Delco Electronics division of General Motors. When the corporation acquired the Hughes Aircraft Company, Delco was merged with it to form Hughes Electronics as an independent subsidiary.
The Alfred P. Sloan Foundation is an American philanthropic nonprofit organization. It was established in 1934 by Alfred P. Sloan Jr., then-president and chief executive officer of General Motors.
Roger David Kornberg is an American biochemist and professor of structural biology at Stanford University School of Medicine. Kornberg was awarded the Nobel Prize in Chemistry in 2006 for his studies of the process by which genetic information from DNA is copied to RNA, "the molecular basis of eukaryotic transcription."
The Charles S. Mott Prize was awarded annually by the General Motors Cancer Research Foundation as one of a trio of scientific prizes entirely devoted to cancer research, the other two being the Charles F. Kettering Prize and the Alfred P. Sloan, Jr. Prize. The prizes, worth US$250,000, were awarded annually between 1979 and 2005. The awards were generally considered the most prestigious in the field.
Napoleone Ferrara is an Italian-American molecular biologist who joined University of California, San Diego Moores Cancer Center in 2013 after a career in Northern California at the biotechnology giant Genentech, where he pioneered the development of new treatments for angiogenic diseases such as cancer, age-related macular degeneration (AMD), and diabetic retinopathy. At Genentech, he discovered VEGF—and made the first anti-VEGF antibody—which suppresses growth of a variety of tumors. These findings helped lead to development of the first clinically available angiogenesis inhibitor, bevacizumab (Avastin), which prevents the growth of new blood vessels into a solid tumor and which has become part of standard treatment for a variety of cancers. Ferrara's work led also to the development of ranibizumab (Lucentis), a drug that is highly effective at preventing vision loss in intraocular neovascular disorders.
The Nobel Memorial Prize in Economic Sciences, officially the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel, is an economics award funded by Sveriges Riksbank and administered by the Nobel Foundation.
Joan Massagué, is a Spanish biologist and the current director of the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center. He is also an internationally recognized leader in the study of both cancer metastasis and growth factors that regulate cell behavior, as well as a professor at the Weill Cornell Graduate School of Medical Sciences.
Thomas J. Kelly is an American cancer researcher whose work focuses on the molecular mechanisms of DNA replication. Kelly is director of the Sloan-Kettering Institute, the basic research arm of the Memorial Sloan-Kettering Cancer Center. He holds the Center's Benno C. Schmidt Chair of Cancer Research.
Bruce William Stillman is a biochemist and cancer researcher who has served as the Director of Cold Spring Harbor Laboratory (CSHL) since 1994 and President since 2003. He also served as the Director of its NCI-designated Cancer Center for 25 years from 1992 to 2016. During his leadership, CSHL has been ranked as the No. 1 institution in molecular biology and genetics research by Thomson Reuters. Stillman's research focuses on how chromosomes are duplicated in human cells and in yeast Saccharomyces cerevisiae; the mechanisms that ensure accurate inheritance of genetic material from one generation to the next; and how missteps in this process lead to cancer. For his accomplishments, Stillman has received numerous awards, including the Alfred P. Sloan, Jr. Prize in 2004 and the 2010 Louisa Gross Horwitz Prize, both of which he shared with Thomas J. Kelly of Memorial Sloan-Kettering Cancer Center, as well as the 2019 Canada Gairdner International Award for biomedical research, which he shared with John Diffley.
James Patrick Allison is an American immunologist and Nobel laureate who holds the position of professor and chair of immunology and executive director of immunotherapy platform at the MD Anderson Cancer Center in Houston, Texas. Dr. Allison is Regental Professor and Founding-Director of James P. Allison Institute at the MD Anderson Cancer Center.
