Annexin A11

ANXA11
Identifiers
Aliases	ANXA11 , ANX11, CAP50, annexin A11, CAP-50, ALS23, IBMWMA
External IDs	OMIM: 602572; MGI: 108481; HomoloGene: 22759; GeneCards: ANXA11; OMA:ANXA11 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.3 Start 80,150,889 bp [1] End 80,205,572 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 A3|14 15.06 cM Start 25,842,580 bp [2] End 25,887,228 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva mucosa of transverse colon apex of heart olfactory zone of nasal mucosa muscle of thigh epithelium of colon right auricle of heart granulocyte left ventricle blood Top expressed in granulocyte muscle of thigh placenta quadriceps femoris muscle colon muscle tissue skeletal muscle tissue ileum jejunum urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding S100 protein binding calcium-dependent protein binding phosphatidylethanolamine binding protein binding MHC class II protein complex binding calcium-dependent phospholipid binding RNA binding Cellular component cytoplasm nuclear envelope membrane melanosome spindle nucleoplasm midbody azurophil granule specific granule phagocytic vesicle extracellular exosome cytoskeleton nucleus cytosol collagen-containing extracellular matrix Biological process cell division response to calcium ion phagocytosis cell cycle cytokinetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 311 11744 Ensembl ENSG00000122359 ENSMUSG00000021866 UniProt P50995 P97384 RefSeq (mRNA) NM_001157 NM_001278407 NM_001278408 NM_001278409 NM_145868 NM_145869 NM_013469 RefSeq (protein) NP_001148 NP_001265336 NP_001265337 NP_001265338 NP_665875 NP_665876 NP_038497 Location (UCSC) Chr 10: 80.15 – 80.21 Mb Chr 14: 25.84 – 25.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified. ^[7]

Interactions

ANXA11 has been shown to interact with PDCD6 ^[8] and ALG2. ^[9]

Clinical significance

It is shown that over-expression of the ANXA11 is involved in apoptotic alterations in schizophrenia and contribute to pathomechanisms of this disorder. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000122359 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021866 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Misaki Y, Pruijn GJ, van der Kemp AW, van Venrooij WJ (Feb 1994). "The 56K autoantigen is identical to human annexin XI". The Journal of Biological Chemistry. 269 (6): 4240–6. doi: 10.1016/S0021-9258(17)41769-8 . PMID   7508441.
6. Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1998). "Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins". Genomics. 48 (1): 100–10. doi:10.1006/geno.1997.5148. PMID   9503022.
7. "Entrez Gene: ANXA11 annexin A11".
8. Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M (Mar 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochemical and Biophysical Research Communications. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. PMID   11883939.
9. Satoh H, Nakano Y, Shibata H, Maki M (Nov 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1600 (1–2): 61–7. doi:10.1016/S1570-9639(02)00445-4. PMID   12445460.
10. Ghazaryan H (Jul 2013). "Annexin 11 expression pattern in schizophrenia". Electronic Journal of Natural Sciences. 21 (2): 74–76.

External links

• Human ANXA11 genome location and ANXA11 gene details page in the UCSC Genome Browser .

Further reading

• Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H (Jul 1992). "Specific binding of CAP-50 to calcyclin". FEBS Letters. 305 (3): 217–9. doi: 10.1016/0014-5793(92)80671-3 . PMID   1299619. S2CID   41323727.
• Dawson SJ, White LA (May 1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". The Journal of Infection. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID   1602151.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Sjölin C, Dahlgren C (Jun 1996). "Isolation by calcium-dependent translation to neutrophil-specific granules of a 42-kD cytosolic protein, identified as being a fragment of annexin XI". Blood. 87 (11): 4817–23. doi: 10.1182/blood.V87.11.4817.bloodjournal87114817 . PMID   8639854.
• Brownawell AM, Creutz CE (Aug 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". The Journal of Biological Chemistry. 272 (35): 22182–90. doi: 10.1074/jbc.272.35.22182 . PMID   9268363.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Sudo T, Hidaka H (Feb 1999). "Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis". FEBS Letters. 444 (1): 11–4. doi:10.1016/S0014-5793(99)00014-9. PMID   10037139. S2CID   25762914.
• Bances P, Fernandez MR, Rodriguez-Garcia MI, Morgan RO, Fernandez MP (Oct 2000). "Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms". Genomics. 69 (1): 95–103. doi:10.1006/geno.2000.6309. PMID   11013079.
• Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M (Mar 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochemical and Biophysical Research Communications. 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. PMID   11883939.
• Satoh H, Nakano Y, Shibata H, Maki M (Nov 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1600 (1–2): 61–7. doi:10.1016/S1570-9639(02)00445-4. PMID   12445460.
• Breen EC, Tang K (Mar 2003). "Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro". Journal of Cellular Biochemistry. 88 (4): 848–54. doi:10.1002/jcb.10398. PMID   12577318. S2CID   23949602.
• Tomas A, Moss SE (May 2003). "Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope". The Journal of Biological Chemistry. 278 (22): 20210–6. doi: 10.1074/jbc.M212669200 . hdl: 10044/1/42329 . PMID   12601007.
• Farnaes L, Ditzel HJ (Aug 2003). "Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display". The Journal of Biological Chemistry. 278 (35): 33120–6. doi: 10.1074/jbc.M210852200 . PMID   12805373.
• Tomas A, Futter C, Moss SE (Jun 2004). "Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis". The Journal of Cell Biology. 165 (6): 813–22. doi:10.1083/jcb.200311054. PMC   2172404 . PMID   15197175.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.