PDCD6

Last updated
PDCD6
Protein PDCD6 PDB 1hqv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PDCD6 , ALG-2, PEF1B, ALG2, programmed cell death 6
External IDs OMIM: 601057 MGI: 109283 HomoloGene: 7880 GeneCards: PDCD6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267556
NM_001267557
NM_001267558
NM_001267559
NM_013232

NM_011051
NM_001359996

RefSeq (protein)

NP_001254485
NP_001254486
NP_001254487
NP_001254488
NP_037364

NP_035181
NP_001346925

Location (UCSC) Chr 5: 0.27 – 0.31 Mb Chr 13: 74.45 – 74.47 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene. [5]

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. [6]

Interactions

PDCD6 has been shown to interact with ASK1, [7] PDCD6IP, [8] [9] Fas receptor, [10] ANXA11 [9] and PEF1. [11]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000249915 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021576 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vito P, Lacana E, D'Adamio L (February 1996). "Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3". Science. 271 (5248): 521–5. Bibcode:1996Sci...271..521V. doi:10.1126/science.271.5248.521. PMID   8560270. S2CID   22286752.
  6. "Entrez Gene: PDCD6 programmed cell death 6".
  7. Hwang, In-Sik; Jung Yong-Sam; Kim Eunhee (October 2002). "Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation". FEBS Lett. 529 (2–3). Netherlands: 183–7. Bibcode:2002FEBSL.529..183H. doi:10.1016/S0014-5793(02)03329-X. ISSN   0014-5793. PMID   12372597. S2CID   9264865.
  8. Vito, P; Pellegrini L; Guiet C; D'Adamio L (January 1999). "Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction". J. Biol. Chem. 274 (3). UNITED STATES: 1533–40. doi: 10.1074/jbc.274.3.1533 . ISSN   0021-9258. PMID   9880530.
  9. 1 2 Satoh, Hirokazu; Shibata Hideki; Nakano Yoshimi; Kitaura Yasuyuki; Maki Masatoshi (March 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochem. Biophys. Res. Commun. 291 (5). United States: 1166–72. doi:10.1006/bbrc.2002.6600. ISSN   0006-291X. PMID   11883939.
  10. Jung, Y S; Kim K S; Kim K D; Lim J S; Kim J W; Kim E (October 2001). "Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells". Biochem. Biophys. Res. Commun. 288 (2). United States: 420–6. doi:10.1006/bbrc.2001.5769. ISSN   0006-291X. PMID   11606059.
  11. Kitaura, Y; Matsumoto S; Satoh H; Hitomi K; Maki M (April 2001). "Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner". J. Biol. Chem. 276 (17). United States: 14053–8. doi: 10.1074/jbc.M008649200 . ISSN   0021-9258. PMID   11278427.

Further reading