Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene. [5]
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. [6]
PDCD6 has been shown to interact with ASK1, [7] PDCD6IP, [8] [9] Fas receptor, [10] ANXA11 [9] and PEF1. [11]
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.
Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.
Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.
Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.
B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene.
PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.
Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.
Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene.
FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.
Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.
Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.
Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.
TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.
Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.
Triadin, also known as TRDN, is a human gene associated with the release of calcium ions from the sarcoplasmic reticulum triggering muscular contraction through calcium-induced calcium release. Triadin is a multiprotein family, arising from different processing of the TRDN gene on chromosome 6. It is a transmembrane protein on the sarcoplasmic reticulum due to a well defined hydrophobic section and it forms a quaternary complex with the cardiac ryanodine receptor (RYR2), calsequestrin (CASQ2) and junctin proteins. The luminal (inner compartment of the sarcoplasmic reticulum) section of Triadin has areas of highly charged amino acid residues that act as luminal Ca2+ receptors. Triadin is also able to sense luminal Ca2+ concentrations by mediating interactions between RYR2 and CASQ2. Triadin has several different forms; Trisk 95 and Trisk 51, which are expressed in skeletal muscle, and Trisk 32 (CT1), which is mainly expressed in cardiac muscle.
NADPH oxidase, EF-hand calcium binding domain 5, also known as NOX5, is a protein which in humans is encoded by the NOX5 gene.
Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.
Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.
Grancalcin is a protein that in humans is encoded by the GCA gene.
Peflin is a protein that in humans is encoded by the PEF1 gene.