Annexin A6

Last updated
ANXA6
Protein ANXA6 PDB 1avc.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ANXA6 , ANX6, CBP68, annexin A6, CPB-II, p70, p68
External IDs OMIM: 114070; MGI: 88255; HomoloGene: 55558; GeneCards: ANXA6; OMA:ANXA6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001155
NM_001193544
NM_004033
NM_001363114

NM_001110211
NM_013472

RefSeq (protein)

NP_001146
NP_001180473
NP_001350043

NP_001103681
NP_038500

Location (UCSC) Chr 5: 151.1 – 151.16 Mb Chr 11: 54.87 – 54.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Annexin A6 is a protein that in humans is encoded by the ANXA6 gene. [5]

Contents

Function

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. [6]

Interactions

ANXA6 has been shown to interact with RAS p21 protein activator 1. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197043 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018340 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Crompton MR, Owens RJ, Totty NF, Moss SE, Waterfield MD, Crumpton MJ (Jan 1988). "Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family". The EMBO Journal. 7 (1): 21–7. doi:10.1002/j.1460-2075.1988.tb02779.x. PMC   454210 . PMID   3258820.
  6. "Entrez Gene: ANXA6 annexin A6".
  7. Chow A, Gawler D (Oct 1999). "Mapping the site of interaction between annexin VI and the p120GAP C2 domain". FEBS Letters. 460 (1): 166–72. Bibcode:1999FEBSL.460..166C. doi:10.1016/S0014-5793(99)01336-8. PMID   10571081. S2CID   42114086.

Further reading