Annexin A9

Last updated
ANXA9
Identifiers
Aliases ANXA9 , ANX31, annexin A9
External IDs OMIM: 603319 MGI: 1923711 HomoloGene: 2643 GeneCards: ANXA9
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003568

NM_001085383
NM_023628
NM_001379545
NM_001379546

RefSeq (protein)

NP_003559

NP_001078852
NP_076117
NP_001366474
NP_001366475

Location (UCSC) Chr 1: 150.98 – 151 Mb Chr 3: 95.2 – 95.21 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Annexin A9 is a protein that in humans is encoded by the ANXA9 gene. [5] [6] [7]

Contents

Function

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [7]

Related Research Articles

<span class="mw-page-title-main">Annexin A2</span> Protein-coding gene in the species Homo sapiens

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.

<span class="mw-page-title-main">Annexin A5</span> Protein-coding gene in the species Homo sapiens

Annexin A5 is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. The function of the protein is unknown; however, annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments.

<span class="mw-page-title-main">Annexin A6</span> Protein-coding gene in the species Homo sapiens

Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.

<span class="mw-page-title-main">PDCD6</span> Protein-coding gene in the species Homo sapiens

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.

<span class="mw-page-title-main">GPR135</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.

<span class="mw-page-title-main">Annexin A4</span> Protein-coding gene in the species Homo sapiens

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.

<span class="mw-page-title-main">SRI (gene)</span> Protein-coding gene in the species Homo sapiens

Sorcin is a protein that in humans is encoded by the SRI gene.

<span class="mw-page-title-main">Annexin A11</span> Protein-coding gene in the species Homo sapiens

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.

<span class="mw-page-title-main">ZNF281</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.

<span class="mw-page-title-main">ANXA8L2</span> Protein

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.

<span class="mw-page-title-main">ALG2</span> Protein-coding gene in the species Homo sapiens

Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.

<span class="mw-page-title-main">ABCA3</span> Protein-coding gene in the species Homo sapiens

ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene.

<span class="mw-page-title-main">ARL6</span> Mammalian protein found in Homo sapiens

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

<span class="mw-page-title-main">SDF4</span> Protein-coding gene in the species Homo sapiens

45 kDa calcium-binding protein is a protein that in humans is encoded by the SDF4 gene.

<span class="mw-page-title-main">SYT7</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.

<span class="mw-page-title-main">Annexin A13</span> Protein-coding gene in the species Homo sapiens

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.

<span class="mw-page-title-main">CPNE6</span> Protein-coding gene in the species Homo sapiens

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.

<span class="mw-page-title-main">CENPK</span> Protein-coding gene in the species Homo sapiens

Centromere protein K is a protein that in humans is encoded by the CENPK gene.

<span class="mw-page-title-main">CPNE4</span> Protein-coding gene in the species Homo sapiens

Copine-4 is a protein that in humans is encoded by the CPNE4 gene.

<span class="mw-page-title-main">Ryanodine receptor 3</span> Transport protein and coding gene in humans

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143412 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015702 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Morgan RO, Fernandez MP (Sep 1998). "Expression profile and structural divergence of novel human annexin 31". FEBS Letters. 434 (3): 300–4. doi: 10.1016/S0014-5793(98)00997-1 . PMID   9742942. S2CID   13751169.
  6. Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1999). "Human annexin 31 genetic mapping and origin". Gene. 227 (1): 33–8. doi:10.1016/S0378-1119(98)00597-6. PMID   9931420.
  7. 1 2 "Entrez Gene: ANXA9 annexin A9".

Further reading