Annexin A9

ANXA9
Identifiers
Aliases	ANXA9 , ANX31, annexin A9
External IDs	OMIM: 603319 MGI: 1923711 HomoloGene: 2643 GeneCards: ANXA9
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,995,634 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,214,487 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right lobe of liver; ; skin of abdomen; ; pancreatic ductal cell; ; amniotic fluid; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; islet of Langerhans; ; kidney; ; cavity of mouth;
	Top expressed in
	esophagus; ; lip; ; seminal vesicula; ; skin of back; ; epidermis; ; hair follicle; ; renal pelvis; ; conjunctival fornix; ; skin of abdomen; ; cornea;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium-dependent phospholipid binding ; calcium ion binding ; acetylcholine receptor activity ; phosphatidylserine binding ; protein binding ; phospholipid binding ; protein homodimerization activity ;
Cellular component	cell surface ; cytosol ;
Biological process	signal transduction ; cell-cell adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	8416
	71790
	ENSG00000143412
	ENSMUSG00000015702
	O76027
	Q9JHQ0
	NM_003568
	NM_001085383 ; NM_023628 ; NM_001379545 ; NM_001379546
	NP_003559
	NP_001078852 ; NP_076117 ; NP_001366474 ; NP_001366475
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Annexin A9 is a protein that in humans is encoded by the ANXA9 gene.^[5]^[6]^[7]

Function

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.^[7]

Related Research Articles

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.

Annexin A5 is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. The function of the protein is unknown; however, annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments.

Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.

Sorcin is a protein that in humans is encoded by the SRI gene.

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.

Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.

Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.

ATP-binding cassette sub-family A member 3 is a protein that in humans is encoded by the ABCA3 gene.

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

45 kDa calcium-binding protein is a protein that in humans is encoded by the SDF4 gene.

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.

Centromere protein K is a protein that in humans is encoded by the CENPK gene.

Copine-4 is a protein that in humans is encoded by the CPNE4 gene.

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene. The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143412 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015702 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Morgan RO, Fernandez MP (Sep 1998). "Expression profile and structural divergence of novel human annexin 31". FEBS Letters. 434 (3): 300–4. doi: 10.1016/S0014-5793(98)00997-1 . PMID 9742942. S2CID 13751169.
↑ Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1999). "Human annexin 31 genetic mapping and origin". Gene. 227 (1): 33–8. doi:10.1016/S0378-1119(98)00597-6. PMID 9931420.
1 2 "Entrez Gene: ANXA9 annexin A9".

External links

Human ANXA9 genome location and ANXA9 gene details page in the UCSC Genome Browser .

Annexin A9

Contents

Function

Related Research Articles

References

External links

Further reading