Chemical structures
Ardisiaquinone A
Ardisiaquinone B
Ardisiaquinone C
Ardisiaquinone D
Ardisiaquinone E
Ardisiaquinone F
Ardisiaquinone G
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Ardisiaquinones are a group of closely related chemical compounds found in plants in the genus Ardisia . The first examples, ardisiaquinones A-C, were isolated in 1968 from Ardisia sieboldii . [1] In 1995, ardisiaquinones D, E, and F were discovered, also from Ardisia sieboldii. [2] In 2001, ardisiaquinones G, H and I were isolated from Ardisia teysmanniana . [3]
Chemically, the ardisiaquinones consist of two variably-substituted 1,4-benzoquinone units connected by a long alkyl or alkenyl chain. [1]
Ardisiaquinones are of research interest because they possess 5-lipoxygenase (5-LOX) inhibitor activity and 5-LOX has clinical relevance in inflammation. [4] For example, ardisiaquinone A protects against liver injury in an animal model of ischemia-reperfusion injury. [5] Likewise, ardisiaquinone G has also shown 5-LOX inhibition. [4] Ardisiaquinone A has also been shown to have an antiallergic effect in an animal model. [6] Other ardisiaquinones have shown antiproliferative and antimicrobial effects in vitro . [7]
Laboratory syntheses of ardisiaquinones A and B have been reported. [8] [9]
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Thunberginol G is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.
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