Ashok Agarwal

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Ashok Agarwal
Ashok Agarwal 2013.jpg
Born
Lucknow, India
NationalityAmerican
Alma mater1965–68:Middle School, Mahanagar Boys High School (Lucknow, India)
1969–70:High School, Central Hindu School (Varanasi, India)
1971–72:Pre-University Course, Central Hindu School (Varanasi, India)
1972–75:BSc (Honors in Zoology), Banaras Hindu University (Varanasi, India)
1975–77:MSc, Specialization in Reproductive Physiology, Banaras Hindu University (Varanasi, India)
1977–83:PhD in Zoology, Specialization in Mammalian Reproductive Biology, Banaras Hindu University (Varanasi, India)
1984–86:Post-Doctoral Fellow (Rockefeller Foundation Fellowship in Reproductive Biology), Harvard Medical School (Boston, United States)
Known forResearch Work in Human Reproductive Medicine
Scientific career
FieldsMedical Scientist, Researcher, Andrologist/Reproductive Biologist
Institutions Cleveland Clinic
Doctoral advisor C. J. Dominic, PhD (BHU, Cantab), FNA, Professor, Dept. of Zoology, Banaras Hindu University (Varanasi, India)
Other academic advisorsAnita P. Hoffer, PhD, Ed.D., Associate Professor and Director of Research in Urology, Harvard Medical School, (Boston, United States) (Post-Doctoral Advisor)
Website American Center for Reproductive Medicine

Ashok Agarwal is the Director of the Andrology Center, and also the Director of Research at the American Center for Reproductive Medicine at Cleveland Clinic, Cleveland, USA. [1] He is Professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, USA. Ashok is a Senior Staff in the Cleveland Clinic's Glickman Urological and Kidney Institute. [1] He has published extensive translational research in human infertility and assisted reproduction.

Contents

Education

Ashok obtained his BSc (Honors) in 1975, MSc in 1977 and PhD in 1983 at Banaras Hindu University, Varanasi (India), [2] under the guidance of Late C. J. Dominic, PhD, FNA. [3] He did his post-doctoral research on a Rockefeller Foundation Fellowship at the Division of Urology, Harvard Medical School and the Brigham and Women's Hospital [2] in Boston, Massachusetts (1984–1986), under the guidance of Anita P. Hoffer, PhD, Ed.D.

Professional life

After his post-doctoral training at Harvard Medical School, Boston, Ashok worked as the Director of the Andrology Laboratory and Sperm Bank at the Newton-Wellesley Hospital, Boston (Medical Director: Robert A. Newton, M.D., F.A.C.S.) between 1986 and 1988. [2] He was then appointed as the Director of Male Infertility Research and as an instructor in surgery and later an Assistant Professor of Urology at Harvard Medical School (Director of Urologic Research: Kevin R. Loughlin, M.D.) between 1988 and 1992. [4] Aside from his teaching responsibilities, Ashok worked as the Coordinator of Andrology Testing in the Reproductive Endocrinology Laboratory in the Brigham and Women's Hospital (Medical Director: George L. Mutter, M.D.). [2] Ashok was appointed in 1993 by the Cleveland Clinic Foundation, Ohio, as the Head of the Clinical Andrology Center, [4] which over the years under his leadership, has become a center of excellence for the diagnosis of male infertility and for fertility preservation of men with oncological conditions in the United States.

Ashok is a board certified Clinical Laboratory Director (HCLD) in Andrology by the American Board of Bioanalysis [5] [6] and an Inspector for the College of American Pathologists "Reproductive Laboratory Program" for accreditation of Andrology and In Vitro Fertilization (IVF) Laboratories. [7] He has served as the Chairman of Board of the American College of Embryology from 2009 to 2012. [8]

He is the Director of the highly successful Summer Internship Course in Reproductive Medicine. [9] In the last 13 years, over 320 pre-med and medical students from across the United States and overseas have graduated from this highly successful annual program. [10]

Ashok is active in basic and clinical research [11] and his laboratory [12] has trained more than 525 basic scientists and clinical researchers from over 55 countries. [13] His American Center for Reproductive Medicine has provided hands on training to 210 candidates in human assisted reproduction (Embryology and Andrology techniques) from 45 countries. [14]

By the number of citations, he is the most cited author of several medicaljournals such as Fertility and Sterility, Urology, Reproductive Biomedicine Online, Andrologia, Reproductive Biology and Endocrinology. [15] Ashok has been invited as a guest speaker to over 30 countries for important international meetings. [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37] [38] [ excessive citations ] He has directed more than a dozen Assisted Reproductive Technology (ART) and Andrology Laboratory Workshops [39] [40] and Symposia [41] [42] [43] [44] in recent years. He is a member of the International Advisory Committee on Male Infertility for the Society for Translational Medicine.

Publications, editorship and reviewership

Ashok has published over 840 research articles and reviews in peer reviewed PubMed-indexed scientific journals. He has also authored over 225 book chapters in specialized medical books, and presented over 830 papers at both national and international scientific meetings. His Hirsch index (h-index) is 150 (Google Scholar) and 107 (Scopus), while his citation count is over 90,653 on Google Scholar. According to ResearchGate, Ashok has an RG Score of 54.37 on 2,193 publications (1245 articles, 54 books, 250 chapters, 486 conference papers). Ashok is ranked as the No. 1 Author in andrology/male Infertility and ART-related research, based on a Global Ranking of Authors Publishing in Andrology or Male Infertility report employing exhaustive searches on the Scopus database. [45] [46] Ashok is currently an editor of 42 medical text books or manuals related to male infertility, ART, fertility preservation, sperm chromatin damage and antioxidants. He is also the Guest Editor of 12 special journal issues and an ad hoc reviewer for over 50 scientific journals. [1]

Ashok serves on the Editorial Board of Asian Journal of Andrology, [47] Human Andrology, [48] Human Fertility, [49] International Brazilian Journal of Urology, [50] International Journal of Fertility & Sterility, [51] Reproductive BioMedicine Online, [52] Reproductive Biology & Endocrinology, [53] Translational Andrology and Urology, [54] The World Journal of Men's Health, [55] and International Journal of Molecular Sciences. [56]

Scientific career

Ashok is the recipient of over 100 research grants and is actively involved in laboratory and clinical studies looking at the efficacy of certain antioxidants in improving the fertility of male patients.

1990–1999

In the early years, Ashok and his team at ACRM studied the physiological levels of reactive oxygen species (ROS) and its relationship with sperm quality in healthy volunteers of unproven fertility and in infertile men. They went on to study the negative effects of oxidative stress generated during sperm processing and cryopreservation during ART procedures on semen quality. Ashok and his researchers looked into the cut-off values for ROS levels to distinguish between fertile and infertile men and the measurement of oxidative stress.

2000-2009

In the following decade, Ashok and his team at ACRM investigated the physiological and pathophysiological effects (both direct and indirect) of endogenous and exogenous ROS. Ashok and his researchers continued to examine normal range of ROS generation to distinguish between fertile and infertile men.

2010–2014

In the new millennium, Ashok and his team at ACRM examined the role of antioxidants (e.g. carnitines, vitamins C and E, pentoxifyline) as defense mechanisms to neutralize and prevent the over-production of ROS in relation to male infertility.

Current research

In the more recent years, Ashok has been working on the studies on molecular markers of oxidative stress, DNA integrity, effect of radio frequency radiation on fertility and fertility preservation in patients with cancer. His research focus currently is on the use of proteomics and bioinformatics tools in discovering the biological processes and pathways underlying OS-induced infertility.

Awards and honors

Membership in professional societies (since)

Publications


A complete repository of Ashok's research publications (1991 – current) is available here. Ashok Agarwal's ORCID ID is https://orcid.org/0000-0003-0585-1026 and his Scopus Author ID is 7401480880. His ResearchGate profile is available here.

Selected scientific publications from Ashok Agarwal

Books

Human Reproduction

  1. Proteomics in Human Reproduction: Biomarkers for Millennials. Authors: Ashok Agarwal, Luna Samanta, Damayanthi Durairajanayagam, Paula Intasqui, 2016, ISBN   978-3-319-48416-7 [79]
  2. Exercise and Human Reproduction: Induced Fertility Disorders and Possible Therapies. Editors: Diana Martin, Stefan Du Plessis, Ashok Agarwal, 2016, ISBN   978-1-4939-3402-7 [80]
  3. Oxidative Stress in Human Reproduction: Shedding Light on a Complicated Phenomenon. Editors: Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Avi Harlev, Gulfam Ahmad, Stefan S. du Plessis, Sandro C. Esteves, Siew May Wang, Damayanthi Durairajanayagam, 2017, ISBN   978-3-319-48425-9 [81]
  4. Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction. Editors: Ralf Henkel, Luna Samanta, Ashok Agarwal, 2018, ISBN   978-0-12-812501-4 [82]

Male Fertility

  1. Studies on Men's Health and Fertility. Editors: Ashok Agarwal, John Aitken, Huan Alvarez, 2012, ISBN   978-1-61779-776-7 [83]
  2. Male Infertility: A Complete Guide to Lifestyle and Environmental Factors. Editors: Stefan Du Plessis, Edmund S. Sabanegh, Ashok Agarwal, 2014, ISBN   978-1-4939-1040-3 [84]
  3. Varicocele and Male Infertility: Current Concepts, Controversies and Consensus. Authors: Alaa Hamada, Sandro C. Esteves, Ashok Agarwal, 2016, ISBN   978-3-319-24934-6 [85]
  4. Varicocele and Male Infertility: A Complete Guide. Authors: Sandro C. Esteves, Chak-Lam Cho, Ahmad Majzoub, Ashok Agarwal, 2019, ISBN   978-3-319-79102-9 [86]
  5. Herbal Medicine in Andrology Authors: Ralf Henkel, Ashok Agarwal, 2021, ISBN   978-01-2815-566-0 [87]

Male Infertility – Management

  1. Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. Editors: Sijo Parekattil, Ashok Agarwal, 2012, ISBN   978-1-4614-3335-4 [88]
  2. Medical and Surgical Management of Male Infertility. Editors: Botros Rizk, Nabil Aziz, Ashok Agarwal, Edmund Sabanegh, 2013, ISBN   978-9350259467 [89]
  3. Understanding Male Infertility Global Practices and Indian Perspective. Editors: Sonia Malik, Ashok Agarwal, 2014, ISBN   978-8-1312-3264-4 [90]
  4. Unexplained Infertility: Pathophysiology, Evaluation and Treatment. Editors: Glen Schattman, Sandro Esteves, Ashok Agarwal, 2015, ISBN   978-1-4939-2140-9 [91]
  5. Male Infertility in Reproductive Medicine: Diagnosis and Management, 1st Edition. Editors: Botros Rizk, Ashok Agarwal, Edmund S. Sabanegh Jr., 2019, ISBN   9781138599291 [92]
  6. Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants second edition. Editors: Sijo Parekattil, Sandro Estevas, Ashok Agarwal, 2020, ISBN   978-3-030-32302-8 [93]

Sperm Chromatin

  1. Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction. Editors: Armand Zini, Ashok Agarwal, 2011, ISBN   978-1-4419-6857-9 [94]
  2. Sperm Chromatin for the Researcher: A Practical Guide. Editors: Armand Zini, Ashok Agarwal, 2013, ISBN   978-1-4614-8458-5 [95]

Female Fertility

  1. Studies on Women's Health. Editors: Ashok Agarwal, Botros Rizk, Nabil Aziz, 2012, ISBN   978-1-62703-041-0 [96]
  2. Endometriosis: A Comprehensive Update. Authors: Sajal Gupta, Avi Harlev, Ashok Agarwal, 2015, ISBN   978-3-319-18307-7 [97]
  3. Puberty: Physiology and Abnormalities. Editors: Philip Kumanov and Ashok Agarwal, Springer Publishing, New York, 2016. ISBN   978-3-319-32122-6 [98]
  4. Recurrent Pregnancy Loss: Evidence-Based Evaluation, Diagnosis and Treatment. Editors: Asher Bashiri, Avi Harlev, Ashok Agarwal, 2016, ISBN   978-3-319-27450-8 [99]

Fertility Preservation

  1. Fertility Preservation: Emerging Technologies and Clinical Applications. Editors: Emre Seli, Ashok Agarwal, 2011, ISBN   978-1-4419-1783-6 [100]
  2. Fertility Preservation in Females: Emerging Technology and Clinical Applications. Editors: Emre Seli, Ashok Agarwal, 2012, ISBN   978-1-4614-5616-2 [101]
  3. Fertility Preservation in Males: Emerging Technology and Clinical Applications. Editors: Emre Seli, Ashok Agarwal, Springer, 2012, ISBN   978-1-4614-5619-3 [102]
  4. The Complete Guide to Male Fertility Preservation. Editors: Ahmad Majzoub, Ashok Agarwal, 2018, ISBN   978-3-319-42396-8 [103]

Assisted Reproductive Techniques (ART)

  1. Quality Management in ART Clinics. Editors: Fabíola Bento, Sandro Esteves, Ashok Agarwal, 2012, ISBN   978-1-4419-7139-5 [104]
  2. Gamete Assessment, Selection and Micromanipulation in ART. Editors: Zsolt Peter Nagy, Alex Varghese, Ashok Agarwal, 2013, ISBN   978-1-4614-8359-5 [105]
  3. Strategies to Ameliorate Oxidative Stress During Assisted Reproduction. Editors: Ashok Agarwal, Damayanthi Durairajanayagam, Gurpriya Virk, Stefan Du Plessis, 2015, ISBN   978-3-319-10259-7 [106]

ART Guides, Manuals, Methods and Protocols

  1. Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices. Editors: Zsolt Peter Nagy, Alex Varghese, Ashok Agarwal, 2012, ISBN   978-1-4419-1780-5 [107]
  2. Clinical Embryology: A Practical Guide. Editors: Zsolt Peter Nagy, Alex Varghese, Ashok Agarwal, 2013, ISBN   978-1-4614-8375-5 [108]
  3. Building and Managing an IVF Laboratory: A Practical Guide. Editors: Zsolt Peter Nagy, Alex Varghese, Ashok Agarwal, 2013, ISBN   978-1-4614-8365-6 [109]
  4. Non-Invasive Sperm Selection for the In Vitro Fertilization: Novel Concepts and Methods. Editors: Ashok Agarwal, Edson Borges Jr., Amanda S. Setti, 2015, ISBN   978-1-4939-1411-1 [110]
  5. Cryopreservation of Mammalian Gametes and Embryos: Methods and Protocols. Editors: Zsolt Peter Nagy, Alex C. Varghese, Ashok Agarwal, 2017, ISBN   978-1-4939-6828-2 [111]
  6. In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices, Second Edition. Editors: Zsolt Peter Nagy, Alex Varghese, Ashok Agarwal, 2019, ISBN   978-3-319-43011-9 [112]

Andrology Laboratory Guides, Manuals and Workbooks

  1. Andrology Laboratory Manual. Editors: Kaimini Rao, Ashok Agarwal, MS Srinivas, 2010, ISBN   978-81-8448-901-9 [113]
  2. Workbook on Human Spermatozoa and Assisted Conceptions [ permanent dead link ‍]. Editors: Sonia Malik, Ashok Agarwal, 2012, ISBN   978-9-350-25517-9 [114]
  3. Andrological Evaluation of Male Infertility: A Laboratory Guide. Editors: Agarwal A, Gupta S, Sharma R, 2016, ISBN   978-3-319-26797-5 [115]
  4. Manual Sperm Retrieval and Preparation in Human Assisted Reproduction. Editors: Ashok Agarwal, Ahmad Majzoub, Sandro Esteves, 2021, ISBN   978-11-0879-215-8 [116]
  5. Manual of Sperm Function Testing in Human Assisted Reproduction. Editors: Ashok Agarwal, Ralf Henkel, Ahmad Majzoub, 2021, ISBN   978-11-0887-871-5 [117]

Guides for Clinicians

  1. Male Infertility for the Clinician: A Practical Guide. Editors: Sijo Parekattil, Ashok Agarwal, 2013, ISBN   978-1-4614-7851-5 [118]
  2. Sperm Chromatin for the Clinician: A Practical Guide. Editors: Armand Zini, Ashok Agarwal, 2013, ISBN   978-1-4614-7842-3 [119]
  3. Antioxidants in Male Infertility: A Guide for Clinicians and Researchers. Editors: Sijo Parekattil, Ashok Agarwal, 2013, ISBN   978-1-4614-9157-6 [120]
  4. The Diagnosis and Treatment of Male Infertility: A Case-Based Guide for Clinicians. Editors: Nabil Aziz, Ashok Agarwal, 2017, ISBN   978-3-319-56545-3 [121]
  5. A Clinician's Guide to Sperm DNA and Chromatin Damage. Editors: Armand Zini, Ashok Agarwal, 2018, ISBN   978-3-319-71815-6 [122]
  6. Genetics of Male Infertility: A Case-Based Guide for Clinicians. Editors: Mohamed Arafa, Haitham Elbardisi, Ahmad Majzoub, Ashok Agarwal, 2020, ISBN   978-3-030-37972-8 [123]

Journal Special Issues (Guest Editor)

  1. Hot Topics in Male Infertility: Panminerva Medica, Volume 61, Issue 2, June 2019 [124]
  2. Hot Topics in Female Infertility: Panminerva Medica, Volume 61, Issue 1, March 2019 [125]
  3. Updates in Male Factor Infertility: Arab Journal of Urology, Volume 16, Issue 1, March 2018. [126]
  4. Sperm DNA Fragmentation: Translational Andrology and Urology, Volume 6, Suppl 4, September 2017. [127]
  5. Varicocele and Male Infertility: Asian Journal of Andrology, Volume 18, Number 2, March 2016. [128]
  6. The Azoospermic Male: Current Knowledge and Future Perspectives: CLINICS, Volume 68, Number 1, February 2013. [129]
  7. Advances in Andrology and Male Reproductive Health: The Open Reproductive Science Journal, Volume 3, 2011. [130]
  8. Current Concepts in Assisted Reproduction and Fertility Preservation (Part II): Current Women’s Health Reviews, Volume 6, Number 3, August 2010. [131]
  9. Current Concepts in Female Infertility Management (Part I): Current Women’s Health Reviews, Volume 6, Number 2, May 2010. [132]
  10. Infertility: Archives of Medical Science, Volume 5 (1A), 2009. [133]
  11. An Update on Clinical Utility and Diagnostic Value of Various Andrological Techniques, Volume 53 (2), 2020. [134]
  12. An Update on Male Infertility: Factors, Mechanisms and Interventions, Volume 53 (1), 2020. [135]
  13. Men’s Health, Volume 19 (3), 2021. [136]

Related Research Articles

<span class="mw-page-title-main">Infertility</span> Inability to reproduce by natural means

Infertility is the inability of a couple to reproduce by natural means. It is usually not the natural state of a healthy adult. Exceptions include children who have not undergone puberty, which is the body's start of reproductive capacity. It is also a normal state in women after menopause.

Andrology is a name for the medical specialty that deals with male health, particularly relating to the problems of the male reproductive system and urological problems that are unique to men. It is the parallel to gynecology, which deals with medical issues which are specific to female health, especially reproductive and urologic health.

<span class="mw-page-title-main">Testicular atrophy</span> Reduction in the size and function of the testicles

Testicular atrophy is a medical condition in which one or both testicles diminish in size and may be accompanied by reduced testicular function. Testicular atrophy is not related to the temporary shrinkage of the surrounding scrotum, which might occur in response to cold temperature.

<span class="mw-page-title-main">Varicocele</span> Abnormal enlargement of the pampiniform plexus veins in the genitals

A varicocele is, in a man, an abnormal enlargement of the pampiniform venous plexus in the scrotum; in a woman, it is an abnormal painful swelling to the embryologically identical pampiniform venous plexus; it is more commonly called pelvic compression syndrome. In the male varicocele, this plexus of veins drains blood from the testicles back to the heart. The vessels originate in the abdomen and course down through the inguinal canal as part of the spermatic cord on their way to the testis. Varicoceles occur in around 15% to 20% of all men. The incidence of varicocele increase with age.

<span class="mw-page-title-main">Spermatogonium</span> Undifferentiated male germ cell

A spermatogonium is an undifferentiated male germ cell. Spermatogonia undergo spermatogenesis to form mature spermatozoa in the seminiferous tubules of the testicles.

<span class="mw-page-title-main">Azoospermia</span> Medical condition of a man whose semen contains no sperm

Azoospermia is the medical condition of a man whose semen contains no sperm. It is associated with male infertility, but many forms are amenable to medical treatment. In humans, azoospermia affects about 1% of the male population and may be seen in up to 20% of male infertility situations in Canada.

<span class="mw-page-title-main">American Society for Reproductive Medicine</span> US medical association

The American Society for Reproductive Medicine (ASRM) is a nonprofit, multidisciplinary organization for advancement of the science and practice of reproductive medicine. The society has its headquarters in Washington, D.C., and its administrative office in Birmingham, Alabama. An associated special interest group, the Society for Assisted Reproductive Technology (SART), maintains a national registry for tracking IVF attempts and outcomes.

Male infertility refers to a sexually mature male's inability to impregnate a fertile female. In humans, it accounts for 40–50% of infertility. It affects approximately 7% of all men. Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity. More recently, advance sperm analyses that examine intracellular sperm components are being developed.

<span class="mw-page-title-main">Testicular sperm extraction</span> Surgical procedure

Testicular sperm extraction (TESE) is a surgical procedure in which a small portion of tissue is removed from the testicle and any viable sperm cells from that tissue are extracted for use in further procedures, most commonly intracytoplasmic sperm injection (ICSI) as part of in vitro fertilisation (IVF). TESE is often recommended to patients who cannot produce sperm by ejaculation due to azoospermia.

<span class="mw-page-title-main">Reproductive medicine</span> Branch of medicine

Reproductive medicine is a branch of medicine concerning the male and female reproductive systems. It encompasses a variety of reproductive conditions, their prevention and assessment, as well as their subsequent treatment and prognosis.

Teratospermia or teratozoospermia is a condition characterized by the presence of sperm with abnormal morphology that affects fertility in males.

Reproductive surgery is surgery in the field of reproductive medicine. It can be used for contraception, e.g. in vasectomy, wherein the vasa deferentia of a male are severed, but is also used plentifully in assisted reproductive technology. Reproductive surgery is generally divided into three categories: surgery for infertility, in vitro fertilization, and fertility preservation.

Marc Goldstein is an American urologist who is the Matthew P. Hardy Distinguished Professor of Reproductive Medicine, and Urology at Weill Cornell Medical College; Surgeon-in-Chief, Male Reproductive Medicine and Surgery; and Director of the Center of Male Reproductive Medicine and Microsurgery at New York Presbyterian Hospital. He is Adjunct Senior Scientist with the Population Council's Center for Biomedical Research, located on the campus of Rockefeller University.

Antisperm antibodies (ASA) are antibodies produced against sperm antigens.

Robert John Aitken is an Anglo-Australian reproductive biologist, widely known for identifying oxidative stress as a significant contribution to infertility and its actions on human sperm function. He also made substantial contributions to clinical practice translation in male reproductive health, notably the development of new contraceptive vaccine.

The male infertility crisis is an increase in male infertility since the mid-1970s. The issue attracted media attention after a 2017 meta-analysis found that sperm counts in Western countries had declined by 52.4 percent between 1973 and 2011. The decline is particularly prevalent in Western countries such as New Zealand, Australia, Europe, and North America. A 2022 meta-analysis reported that this decline extends to non-Western countries, namely those in Asia, Africa, Central America, and South America. This meta-analysis also suggests that the decline in sperm counts may be accelerating.

Sarah Martins da SilvaFRCOG is a British gynaecologist and researcher specialising in male infertility. Martins da Silva is a Clinical Reader in reproductive medicine at the University of Dundee. She also works as an honorary consultant gynaecologist at Ninewells Hospital in Dundee, specialising in fertility problems and assisted conception. She was named one of the BBC's "100 Women of 2019" for her contribution to fertility science.

<span class="mw-page-title-main">Sperm Chromatin Structure Assay</span>

Sperm Chromatin Structure Assay (SCSA) is a diagnostic approach that detects sperm abnormality with a large extent of DNA fragmentation. First described by Evenson in 1980, the assay is a flow cytometric test that detects the vulnerability of sperm DNA to acid-induced denaturation DNA in situ. SCSA measures sperm DNA fragmentation attributed to intrinsic and extrinsic factors and reports the degree of fragmentation in terms of DNA Fragmentation Index (DFI). The use of SCSA expands from evaluation of male infertility and subfertility, toxicology studies and evaluation of quality of laboratory semen samples. Notably, SCSA outcompetes other convention sperm DNA fragmentation (sDF) assays such as TUNEL and COMET in terms of efficiency, objectivity, and repeatability.

Ranjith Ramasamy is a consultant urologist at Jumeirah American Clinic in Dubai, UAE, and the former Director of the Reproductive Urology Fellowship program at the University of Miami's Miller School of Medicine.

<span class="mw-page-title-main">Larry Lipshultz</span> American urologist

Larry I. Lipshultz is an American urologist, surgeon, researcher, and teacher. He currently serves as Professor of Urology, Lester and Sue Smith Endowed Chair in Reproductive Medicine, and Chief of the Scott Department of Urology's Division of Male Reproductive Medicine and Surgery at Baylor College of Medicine, Houston, Texas.

References

  1. 1 2 3 "Ashok Agarwal, PhD, HCLD, American Center for Reproductive Medicine, Cleveland Clinic".
  2. 1 2 3 4 "Ashok Agarwal, short biography in American College of Embryology".
  3. ↑ "Biography of Late Professor CJ Dominic" (PDF).
  4. 1 2 "Ashok Agarwal, PhD, Cleveland Clinic Staff Directory".
  5. ↑ "High Complexity Clinical Lab Director, American Board of Bioanalysis, St. Louis, MO, 1995" (PDF).
  6. ↑ "High Complexity Clinical Lab Director, American Board of Bioanalysis, 2020" (PDF).
  7. ↑ "Ashok Agarwal, PhD, HCLD (ABB) Certificate 2015" (PDF).
  8. ↑ "History of the American College of Embryology".
  9. ↑ "Summer Mentorship Program in Reproductive Medicine and Research 2016".
  10. ↑ "ACRM Alumni Brochure" (PDF).
  11. ↑ "Research Fellowship Booklet" (PDF).
  12. ↑ "Andrology Lab Booklet" (PDF).
  13. ↑ "ACRM Alumni Brochure" (PDF).
  14. ↑ "ART Training Flyer" (PDF).
  15. ↑ "Ashok Agarwal citation rankings". Exaly. Retrieved 6 June 2022.
  16. ↑ "Visiting Professor, Federal University of Sao Paulo, Brazil, 1999" (PDF).
  17. ↑ "Visiting Professor, Faculty of Medicine of the University of Sao Paulo, Brazil, 1999" (PDF).
  18. ↑ "Visiting Professor, Polish Academy of Sciences, Poland, 2000" (PDF).
  19. ↑ "Visiting Professor, Chiba University School of Medicine, Japan, 2000" (PDF).
  20. ↑ "Visiting Professor, Osaka University, Japan, 2000" (PDF).
  21. ↑ "Visiting Professor, Moonhwa Hospital, South Korea, 2000" (PDF).
  22. ↑ "Visiting Professor, C.S.M. Medical University, India, 2002" (PDF).
  23. ↑ "Visiting Professor, Shahid Saduoghi University of Medical Sciences and Health Services, Iran, 2004" (PDF).
  24. ↑ "Visiting Professor, Avesina Research Center, Iran, 2004" (PDF).
  25. ↑ "Visiting Professor, Tulane University School of Medicine, Louisiana, 2004" (PDF).
  26. ↑ "Visiting Professor, Peking University Third Hospital, China, 2004" (PDF).
  27. ↑ "Visiting Professor, Medical University, Bulgaria, 2005" (PDF).
  28. ↑ "Visiting Professor, The VI Meeting of Antioxidants and Lifestyle, Argentina, 2005" (PDF).
  29. ↑ "Visiting Professor, United Kingdom, 2005" (PDF).
  30. ↑ "Visiting Professor, USICON, India, 2008" (PDF).
  31. ↑ "Visiting Professor, Stellenbosch University, South Africa, 2011" (PDF).
  32. ↑ "Forum of Male Reproductive Health, Wenzhou, China, 2017" (PDF).
  33. ↑ "Dr. Sulochana Gunasheela Memorial Conference, Bengaluru, India, 2017" (PDF).
  34. ↑ "International Symposium on Male Infertility, Hyderabad, India 2017" (PDF).
  35. ↑ "55th Congreso Mexicano de Medicina de la Reproduccion, Mexico 2018" (PDF).
  36. ↑ "The Korea Institute for Public Sperm Bank, Korea 2019" (PDF).
  37. ↑ "FERTIVISION 2019, India 2019" (PDF).
  38. ↑ "64th Annual Meeting of Japan Society for Reproductive Medicine, Kobe, Japan, 2019" (PDF).
  39. ↑ "Alpha-KED-CRM Andrology Pre-Congress Workshop 2014 at Antalya, Turkey" (PDF).
  40. ↑ "International Embryology Summit 2012 at Mumbai, India" (PDF).
  41. ↑ "International Reproductive Medicine Symposium 2008 at Cleveland Clinic Lerner Research Institute" (PDF).
  42. ↑ "Mini Symposium on Advances in the Management of Male Infertility 2009 at Cleveland Clinic Lerner Research Institute" (PDF).
  43. ↑ "Symposium on Infertility and Reproductive Medicine 2010 at Dubai, UAE" (PDF).
  44. ↑ "Symposia on Understanding Infertility 2011 at New Delhi, India" (PDF).
  45. ↑ Agarwal, Ashok; Durairajanayagam, Damayanthi; Tatagari, Sindhuja; Esteves, Sandroc; Harlev, Avi; Henkel, Ralf; Roychoudhury, Shubhadeep; Homa, Sheryl; Puchalt, Nicolásgarrido; Ramasamy, Ranjith; Majzoub, Ahmad; Ly, Kimdao; Tvrda, Eva; Assidi, Mourad; Kesari, Kavindra; Sharma, Reecha; Banihani, Saleem; Ko, Edmund; Abu-Elmagd, Muhammad; Gosalvez, Jaime; Bashiri, Asher (2016). "Bibliometrics: tracking research impact by selecting the appropriate metrics" (PDF). Asian J Androl. 18 (2): 296–309. doi: 10.4103/1008-682X.171582 . PMC   4770502 . PMID   26806079.
  46. ↑ Zhang, Y.; Xiao, F.; Lu, S.; Song, J.; Zhang, C.; Li, J.; Gu, K.; Lan, A.; Lv, B.; Zhang, R.; Mo, F.; Jiang, G.; Zhang, X.; Yang, X. (November 2016). "Research trends and perspectives of male infertility: a bibliometric analysis of 20 years of scientific literature" (PDF). Andrology. 4 (6): 990–1001. doi:10.1111/andr.12204. PMID   27389996. S2CID   3533870.
  47. ↑ "Editorial Board Asian Journal of Andrology". Archived from the original on 19 August 2014.
  48. ↑ "Editorial Board Member of Human Andrology".
  49. ↑ "Editorial Advisory Board Member of Human Fertility".
  50. ↑ "Editorial Board Member of International Brazilian Journal of Urology".
  51. ↑ "Editorial Board Member of International Journal of Fertility & Sterility".
  52. ↑ "Editorial Board Member of Reproductive BioMedicine Online".
  53. ↑ "Editorial Board Member of Reproductive Biology and Endocrinology".
  54. ↑ "Editorial Board Member of Translational Andrology and Urology".
  55. ↑ "Editorial Board Member of World Journal of Men's Health".
  56. ↑ "Editorial Board Member of International Journal of Molecular Sciences".
  57. ↑ "2011 Innovator Award" (PDF).
  58. ↑ "2012 Innovator Award" (PDF).
  59. ↑ "ASRM 2010 Star Award".
  60. ↑ "ASRM 2011 Star Award" (PDF).
  61. ↑ "ASRM 2013 Star Award" (PDF).
  62. ↑ "ASRM 2016 Star Award" (PDF).
  63. ↑ "ASRM 2017 Star Award" (PDF).
  64. ↑ "ASRM 2018 Star Award" (PDF).
  65. ↑ "ASRM 2019 Star Award" (PDF).
  66. ↑ "2011 Scholarship in Teaching Award for Summer Internship Program" (PDF).
  67. ↑ "2013 Scholarship in Teaching Award for Summer Internship Program" (PDF).
  68. ↑ "2014 Scholarship in Teaching Award for Summer Internship Program" (PDF).
  69. ↑ "2017 Summer Internship Course in Reproductive Medicine".
  70. ↑ "2013 Scholarship in Teaching Award for Training Program in Advanced Reproductive Techniques" (PDF).
  71. ↑ "2014 Scholarship in Teaching Award for Training Program in Advanced Reproductive Techniques" (PDF).
  72. ↑ "Hands-On Training Program in Advanced Reproductive Techniques".
  73. ↑ "Asian Journal of Andrology Outstanding Paper Award 2017" (PDF).
  74. ↑ "Certificate of Distinction in Andrology Research" (PDF).
  75. 1 2 "Asian Journal of Andrology Outstanding Paper Award 2018".
  76. ↑ "IVF Expert of the Year" (PDF).
  77. ↑ "American College of Embryology (EMBCOL)".
  78. ↑ "World Journal of Men's Health Most Cited Article Award 2019".
  79. ↑ Proteomics in Human Reproduction: Biomarkers for Millennials. SpringerBriefs in Reproductive Biology. Springer. 2016. ISBN   9783319484167.
  80. ↑ Exercise and Human Reproduction: Induced Fertility Disorders and Possible Therapies. Springer. 2016. ISBN   9781493934003.
  81. ↑ Oxidative Stress in Human Reproduction: Shedding Light on a Complicated Phenomenon. Springer. 2017. ISBN   9783319484259.
  82. ↑ "Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction".
  83. ↑ Studies on Men's Health and Fertility. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. 2012. ISBN   9781617797750.
  84. ↑ Male Infertility: A Complete Guide to Lifestyle and Environmental Factors. Springer. 2014. ISBN   9781493910397.
  85. ↑ Varicocele and Male Infertility: Current Concepts, Controversies and Consensus. SpringerBriefs in Reproductive Biology. Springer. 2016. ISBN   9783319249346.
  86. ↑ Varicocele and Male Infertility: A Complete Guide. Medical Textbooks. Springer. 2019. ISBN   9783319791012.
  87. ↑ Herbal Medicine in Andrology. Medical Textbooks. Elsevier. 2021. ISBN   9780128155660.
  88. ↑ Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. Springer. 2012. ISBN   9781461433347.
  89. ↑ Rizk, Botros R. M. B.; Aziz, Nabil; Agarwal, Ashok; Jr, Edmund Sabanegh (31 August 2013). Medical and Surgical Management of Male Infertility. Jaypee Brothers Medical Publishers Pvt. Limited. ISBN   978-9350259467.
  90. ↑ "Understanding Male Infertility Global practices and Indian Perspective".
  91. ↑ Unexplained Infertility: Pathophysiology, Evaluation and Treatment. Springer. 2015. ISBN   9781493921393.
  92. ↑ "Male Infertility in Reproductive Medicine: Diagnosis and Management, 1st Edition".
  93. ↑ Parekattil, Sijo J; Esteves, Sandro C; Agarwal, Ashok, eds. (2020). Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. Springer. doi:10.1007/978-3-030-32300-4. ISBN   9783030323028. S2CID   69044221.
  94. ↑ Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction. Springer. 2011. ISBN   9781441917812.
  95. ↑ Sperm Chromatin for the Research: A Practical Guide. Springer. 2013. ISBN   9781461484585.
  96. ↑ Studies on Women's Health. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press. 2013. ISBN   9781627030403.
  97. ↑ Endometriosis: A Comprehensive Update. SpringerBriefs in Reproductive Biology. Springer. 2015. ISBN   9783319183077.
  98. ↑ Puberty: Physiology and Abnormalities. Springer. 2016. ISBN   9783319321202.
  99. ↑ Recurrent Pregnancy Loss: Evidence-Based Evaluation, Diagnosis and Treatment. Springer. 2016. ISBN   9783319274508.
  100. ↑ Fertility Preservation: Emerging Technologies and Clinical Applications. Springer. 2012. ISBN   9781461456193.
  101. ↑ Fertility Preservation in Females: Emerging Technology and Clinical Applications. Springer. 2012. ISBN   9781461456162.
  102. ↑ Fertility Preservation in Males: Emerging Technology and Clinical Applications. Springer. 2012. ISBN   9781461456193.
  103. ↑ The Complete Guide to Male Fertility Preservation. Springer. 2018. ISBN   9783319423951.
  104. ↑ Quality Management in ART Clinics. Springer. 2013. ISBN   9781441971388.
  105. ↑ Gamete Assessment, Selection and Micromanipulation in ART. Springer. 2013. ISBN   9781461483595.
  106. ↑ Strategies to Ameliorate Oxidative Stress During Assisted Reproduction. SpringerBriefs in Reproductive Biology. Springer. 2014. ISBN   9783319102580.
  107. ↑ Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices. Springer. 2012. ISBN   9781493940646.
  108. ↑ Clinical Embryology: A Practical Guide. Springer. 2013. ISBN   9781461483755.
  109. ↑ Building and managing an IVF Laboratory: A Practical Guide. Springer. 2013. ISBN   9781461483656.
  110. ↑ Non-Invasive Sperm Selection for the In Vitro Fertilization: Novel Concepts and Methods. Springer. 2015. ISBN   9781493914104.
  111. ↑ Cryopreservation of Mammalian Gametes and Embryos: Methods and Protocols. Methods in Molecular Biology. Humana Press. 2017. ISBN   9781493968268.
  112. ↑ In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices, Second Edition. Medical Textbooks. Springer. 2019. ISBN   9783319430119.
  113. ↑ "Andrology Laboratory Manual".
  114. ↑ "Workbook on Human Spermatozoa and Assisted Conceptions".[ permanent dead link ]
  115. ↑ Andrological Evaluation of Male Infertility: A Laboratory Guide. Springer. 2016. ISBN   9783319267951.
  116. ↑ Manual of Sperm Retrieval and Preparation in Human Assisted Reproduction. Cambridge. 2021. ISBN   9781108792158.
  117. ↑ Agarwal, Ashok; Henkel, Ralf; Majzoub, Ahmad, eds. (2021). Manual of Sperm Function Testing in Human Assisted Reproduction. Cambridge. doi:10.1017/9781108878715. ISBN   9781108878715. S2CID   241256577.
  118. ↑ Male Infertility for the Clinician: A Practical Guide. Springer. 2013. ISBN   9781461478515.
  119. ↑ Sperm Chromatin for the Clinician: A Practical Guide. Springer. 2013. ISBN   9781461478423.
  120. ↑ Antioxidants in Male Infertility: A Guide for Clinicians and Researchers. Springer. 2013. ISBN   9781461491576.
  121. ↑ The Diagnosis and Treatment of Male Infertility: A Case-Based Guide for Clinicians. Springer. 2017. ISBN   9783319565453.
  122. ↑ A Clinician's Guide to Sperm DNA and Chromatin Damage.
  123. ↑ AGenetics of Male Infertility: A Case-Based Guide for Clinicians.
  124. ↑ "Agarwal, A., Esteves, SC., Humaidan, P., & Roque, M. (2019). "Hot Topics in Male Infertility." Panminerva Medica, Volume 61, Issue 2, pp. 101–199".
  125. ↑ "Esteves, SC., Humaidan, P., Roque, M., & Agarwal, A. (2019). "Hot Topics in Female Infertility." Panminerva Medica, Volume 61, Issue 1, pp. 1–99".
  126. ↑ "Agarwal, A., Majzoub, A., Arafa, M & Elbardisi, H. (2018). "Updates in Male Factor Infertility." Arab Journal of Urology, Volume 16, Issue 1, pp. 1–196".
  127. ↑ "Agarwal, A., Majzoub, A., Esteves, SC & Cho, C. (2017). "Sperm DNA Fragmentation." Translational Andrology and Urology, Volume 6, Suppl 4".
  128. ↑ ""Agarwal, A. & Esteves, S. C. (2016). "Varicocele and Male Infertility." Asian Journal of Andrology, Volume 18, Number 2".
  129. ↑ Esteves, S. C.; Agarwal, A. (2013). ""Esteves, S. C., & Agarwal, A. (2013). "The Azoospermic Male: Current Knowledge and Future Perspectives." Clinics, 68, 2013, pp. 1–4". Clinics (Sao Paulo). 68 (Suppl 1): 1–4. doi:10.6061/clinics/2013(Sup01)01. PMC   3583158 . PMID   23503949.
  130. ↑ "Agarwal, A., Esteves, SC., "Advances in Andrology and Male Reproductive Health." Bentham Open, special issue of The Open Reproductive Science Journal, vol. 3, 2011, pp. 1–6".
  131. ↑ "Gupta, S., Agarwal, A., "Current Concepts in Assisted Reproduction and Fertility Preservation (Part II)." Special issue of Current Women's Health Reviews, vol. 6, no. 3, 2010, pp 197–286".
  132. ↑ "Gupta, S., Agarwal, A., "Current Concepts in Female Infertility Management (Part I)." Special issue of Current Women's Health Reviews, vol. 6, no. 2, 2010, pp 68–196".
  133. ↑ "Agarwal, A., "Infertility." Special issue of Archives of Medical Sciences, vol. 5, no. 1, 2009, pp 51–195".
  134. ↑ Baskaran, Saradha; Agarwal, A.; Durairajanayagam, D.; Vij, S. (2021). "Agarwal, A., "An Update on Clinical Utility and Diagnostic Value of Various Andrological Techniques, vol. 53, no. 2, 2020". Andrologia. 53 (2): e13783. doi: 10.1111/and.13783 . PMID   33620115. S2CID   231991271.
  135. ↑ "Agarwal,A. "An Update on Male Infertility: Factors, Mechanisms and Interventions", vol. 53, no. 1, 2020".
  136. ↑ "Agarwal, A., "Men's Health." Special issue in Arab Journal of Medicine, vol. 19, no. 3, 2021, pp 205". Taylor & Francis.
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