Asim Kanti Duttaroy | |
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| Born | July 8, 1955 |
| Website | www |
Asim K. Duttaroy is an Indian-born American medical scientist who, since 2001, has worked as a Professor at the Faculty of Medicine, University of Oslo, Norway. [1] He was born in Gopinagar (Gangnapur), Nadia district, West Bengal, India.[ citation needed ]
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Duttaroy is the author of over 500 research papers and book chapters, has authored or edited several books, and holds several international patents. [2] His research contributions have led to several industrial developments worldwide, such as Provexis.[ citation needed ] [3] Duttaroy, while he worked as Professor (1990-2001) at the Rowett Research Institute at the University of Aberdeen, Scotland, United Kingdom, discovered that an extract from tomato had a positive effect in the prevention of blood platelet aggregation. [4] [5] [6] Hyperactive platelets are important mediators of atherogenesis. In addition to their roles in thrombosis, antiplatelet drugs are not suitable for use where the risk of a cardiovascular event is relatively low. Therefore, it is essential to find alternative, safe antiplatelet inhibitors for the vulnerable population with hyperactive platelets in order to reduce the risk of cardiovascular disease. Potent antiplatelet factors were identified in water-soluble tomato extract (Fruitflow®), significantly inhibiting platelet aggregation. It became the first product in Europe to receive an approved health claim under Article 13(5) of the European Health Claims Regulation 1924/2006 and is now commercially available in over 75 countries.
Another area of his research has been the investigation of the fatty acid transport system in human placenta and its roles in the placental preferential transfer of critically important nutrients such as docosahexaenoic acid,22:6n-3 (DHA) and arachidonic acid,20:4n-6 (ARA) from the mother to the fetus. [7] He demonstrated the presence of several plasma membrane-located transport/binding proteins, such as fatty acid translocase (FAT/CD36), plasma membrane fatty acid binding protein (FABPpm), fatty acid transport protein (FATP), and intracellular FABPs, in the human placenta. He identified the placental-specific FABPpm is mainly responsible for the preferential placental transport of DHA and ARA from the mother to support fetal brain growth during the third trimester.
α-Tocopherol-Binding Protein: Vitamin E is transported in plasma mainly by lipoproteins, but little is known about how it is transported intracellularly. Duttaroy identified a new α-tocopherol-binding protein with a molecular mass of 14.2 kDa found in the cytosol of the heart and liver. [8] [9] This protein specifically binds α-tocopherol more than δ- and γ-homologues but does not bind oleate. [10] [11] The binding is quick, reversible, and saturable, indicating a specialized role in the intracellular transport and metabolism of α-tocopherol.1–4 The discovery of these binding proteins is vital for understanding how α-tocopherol is distributed within cells and tissues. Since α-tocopherol is a powerful antioxidant, proper localization is crucial for protecting cellular membranes from oxidative damage. Disruptions in the function of these binding proteins could weaken the protective effects of α-tocopherol, potentially leading to cellular problems and contributing to various diseases.
Duttaroy serves as Editor-In-Chief of the peer-reviewed journal Food & Nutrition Research , [12] which has an Impact factor of 3.4 (2024).[ citation needed ] Duttaroy serves on the editorial boards of several other journals, including Prostaglandins Leukotrienes and Essential Fatty Acids, [13] Nutrients, [14] and European Journal of Lipid Science and Technology. [15]
