Asim Duttaroy

Last updated
Asim Kanti Duttaroy
Asim Dutta Roy.jpg
Born (1955-07-08) July 8, 1955 (age 68)
Gangnapur, West Bengal, India
Website www.asimduttaroy.com

Asim K. Duttaroy is an Indian-born American medical scientist who, since 2001, has worked as a Professor at the Faculty of Medicine, University of Oslo, Norway. [1] He was born in Gopinagar (Gangnapur), Nadia district, West Bengal, India.[ citation needed ]

Contents

Duttaroy is the author of over 390 research papers and book chapters, has authored or edited several books, and holds several international patents. [2] His research contributions have led to several industrial developments worldwide, such as Provexis.[ citation needed ] [3] Duttaroy, while he worked as Professor (1990-2001) at the Rowett Research Institute at the University of Aberdeen, Scotland, United Kingdom, discovered that an extract from tomato had a positive effect in the prevention of blood platelet aggregation. [4] [5] [6] Hyperactive platelets are important mediators of atherogenesis. In addition to their roles in thrombosis, antiplatelet drugs are not suitable for use where the risk of a cardiovascular event is relatively low. Therefore, it is essential to find alternative, safe antiplatelet inhibitors for the vulnerable population with hyperactive platelets in order to reduce the risk of cardiovascular disease. Potent antiplatelet factors were identified in water-soluble tomato extract (Fruitflow®), significantly inhibiting platelet aggregation.

Another area of his research has been the investigation of the fatty acid transport system in human placenta and its roles in the placental preferential transfer of critically important nutrients such as docosahexaenoic acid,22:6n-3 (DHA) and arachidonic acid,20:4n-6 (ARA) from the mother to the fetus. [7] He demonstrated the presence of several plasma membrane-located transport/binding proteins, such as fatty acid translocase (FAT/CD36), plasma membrane fatty acid binding protein (FABPpm), fatty acid transport protein (FATP), and intracellular FABPs, in the human placenta. He identified the placental-specific FABPpm is mainly responsible for the preferential placental transport of DHA and ARA from the mother to support fetal brain growth during the third trimester.

Duttaroy serves as Editor-In-Chief of the peer-reviewed journal Food & Nutrition Research , [8] which has an Impact factor of 3.89 (2020).[ citation needed ] Duttaroy serves on the editorial boards of several other journals, including Prostaglandins Leukotrienes and Essential Fatty Acids, [9] Nutrients, [10] and European Journal of Lipid Science and Technology. [11]

Legacy

Duttaroy’s research focuses on how the placenta transports maternal plasma DHA and ARA to the fetus. [12] [13] [14] The fetal brain development in utero is critically dependent on the maternal supply of these fatty acids in the utero. [15] [16] [17] [18] His studies have been documented through several articles. [19] [20] Besides, his articles have drawn many citations (Google Scholar PubMed). His other research area is cardioprotective factors in fruits and vegetables. He has discovered the anti-platelet factors from tomatoes. [21] This discovery made by him is now widely known as Fruitflow. [22] [23] In 2009, Fruitflow® became the first product in Europe to obtain an approved, proprietary health claim under Article 13(5) of the European Health Claims Regulation 1924/2006 on nutrition and health claims made on foods. [24] The EU Commission authorized the health claim “water-soluble tomato concentrate (WSTC) I and II help maintain normal platelet aggregation, which contributes to healthy blood flow.”. [25] [26] Fruitflow® is now widely available in different countries worldwide. [27]

Books

Related Research Articles

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Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health, but cannot synthesize them.

<span class="mw-page-title-main">Choline</span> Chemical compound and essential nutrient

Choline ( KOH-leen) is an essential nutrient for humans and many other animals, which was formerly classified as a B vitamin (vitamin B4). It is a structural part of phospholipids and a methyl donor in metabolic one-carbon chemistry. The compound is related to trimethylglycine in the latter respect. It is a cation with the chemical formula [(CH3)3NCH2CH2OH]+. Choline forms various salts, for example choline chloride and choline bitartrate.

<span class="mw-page-title-main">Arachidonic acid</span> Fatty acid used metabolically in many organisms

Arachidonic acid is a polyunsaturated omega-6 fatty acid 20:4(ω-6), or 20:4(5,8,11,14). It is structurally related to the saturated arachidic acid found in cupuaçu butter. Its name derives from the ancient Greek neologism arachis (peanut), but peanut oil does not contain any arachidonic acid.

Fish oil is oil derived from the tissues of oily fish. Fish oils contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), precursors of certain eicosanoids that are known to reduce inflammation in the body and improve hypertriglyceridemia. There has been a great deal of controversy in the 21st century about the role of fish oil in cardiovascular disease, with recent meta-analyses reaching different conclusions about its potential impact.

<span class="mw-page-title-main">Eicosapentaenoic acid</span> Chemical compound

Eicosapentaenoic acid is an omega-3 fatty acid. In physiological literature, it is given the name 20:5(n-3). It also has the trivial name timnodonic acid. In chemical structure, EPA is a carboxylic acid with a 20-carbon chain and five cis double bonds; the first double bond is located at the third carbon from the omega end.

<span class="mw-page-title-main">Docosahexaenoic acid</span> Chemical compound

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. It is given the fatty acid notation 22:6(n-3). It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk, fatty fish, fish oil, or algae oil. The consumption of DHA contributes to numerous physiological benefits, including cognition. As the primary structural component of nerve cells in the brain, the function of DHA is to support neuronal conduction and to allow optimal function of neuronal membrane proteins.

<span class="mw-page-title-main">Resolvin</span> Class of chemical compounds

Resolvins are specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as from two isomers of docosapentaenoic acid (DPA), one omega-3 and one omega-6 fatty acid. As autacoids similar to hormones acting on local tissues, resolvins are under preliminary research for their involvement in promoting restoration of normal cellular function following the inflammation that occurs after tissue injury. Resolvins belong to a class of polyunsaturated fatty acid (PUFA) metabolites termed specialized proresolving mediators (SPMs).

<span class="mw-page-title-main">Nutrition and pregnancy</span> Nutrient intake and dietary planning undertaken before, during and after pregnancy

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<span class="mw-page-title-main">Human placental lactogen</span> Polypeptide placental hormone in humans

Human placental lactogen (hPL), also called human chorionic somatomammotropin (hCS) or human chorionic somatotropin, is a polypeptide placental hormone, the human form of placental lactogen. Its structure and function are similar to those of human growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate energy supply to the fetus. hPL has anti-insulin properties. hPL is a hormone secreted by the syncytiotrophoblast during pregnancy. Like human growth hormone, hPL is encoded by genes on chromosome 17q22-24. It was identified in 1963.

Docosapentaenoic acid (DPA) designates any straight open chain polyunsaturated fatty acid (PUFA) which contains 22 carbons and 5 double bonds. DPA is primarily used to designate two isomers, all-cis-4,7,10,13,16-docosapentaenoic acid and all-cis-7,10,13,16,19-docosapentaenoic acid. They are also commonly termed n-6 DPA and n-3 DPA, respectively; these designations describe the position of the double bond being 6 or 3 carbons closest to the (omega) carbon at the methyl end of the molecule and is based on the biologically important difference that n-6 and n-3 PUFA are separate PUFA classes, i.e. the omega-6 fatty acids and omega-3 fatty acids, respectively. Mammals, including humans, can not interconvert these two classes and therefore must obtain dietary essential PUFA fatty acids from both classes in order to maintain normal health.

<span class="mw-page-title-main">Linoleoyl-CoA desaturase</span> Class of enzymes

Linoleoyl-CoA desaturase (also Delta 6 desaturase, EC 1.14.19.3) is an enzyme that converts between types of fatty acids, which are essential nutrients in the human body. The enzyme mainly catalyzes the chemical reaction

<span class="mw-page-title-main">ALOX12</span> Protein-coding gene in the species Homo sapiens

ALOX12, also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p13.3. ALOX12 is 75 kilodalton protein composed of 663 amino acids.

<span class="mw-page-title-main">CYP4F8</span> Protein-coding gene in the species Homo sapiens

Cytochrome P450 4F8 is a protein that in humans is encoded by the CYP4F8 gene.

<span class="mw-page-title-main">Oxylipin</span> Class of lipids

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<span class="mw-page-title-main">Maresin</span> Chemical compound

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<span class="mw-page-title-main">Seaweed oil</span>

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<span class="mw-page-title-main">Acetyleugenol</span> Chemical compound

Acetyleugenol is a phenylpropanoid compound found in cloves. It is the second in abundance to the related compound eugenol in certain extract preparations. Like eugenol, its found in several plants such as Acacia nilotica and Piper betle and has similar antibacterial and antifungal properties on C. albicans and S. mutans. It inhibits aggregation of platelets and has partial agonistic activity on AhR.

References

  1. ↑ "Asim K. Duttaroy- Institute of Basic Medical Sciences". uio.no. Retrieved 28 June 2016.
  2. ↑ "Research Gate: Asim K. Duttaroy". uio.no. Retrieved 6 August 2016.
  3. ↑ "Provexis- Home Page".
  4. ↑ "Recent Achievements, Rowett Institute" . Retrieved 21 August 2018.
  5. ↑ O'Kennedy, N; Crosbie, L; Van Lieshout, M; Broom, J. I.; Webb, D. J.; Duttaroy, A. K. (2006). "Effects of antiplatelet components of tomato extract on platelet function in vitro and ex vivo: A time-course cannulation study in healthy humans". The American Journal of Clinical Nutrition. 84 (3): 570–9. doi: 10.1093/ajcn/84.3.570 . PMID   16960171.
  6. ↑ Duttaroy, Asim K. "Fruitflow". Rowett Institute of Nutrition and Health - University of Aberdeen. Retrieved 22 September 2016.
  7. ↑ Duttaroy, A (2009). "Transport of fatty acids across the human placenta: A review". Progress in Lipid Research. 48 (1): 52–61. doi:10.1016/j.plipres.2008.11.001. PMID   19041341.
  8. ↑ "Editorial Team". foodandnutritionresearch.net. Retrieved 28 June 2016.
  9. ↑ "Editorial Team". Prostaglandins Leukotrienes and Essential Fatty Acids. Retrieved 19 July 2016.
  10. ↑ "Editorial Team". Nutrients. Retrieved 5 September 2018.
  11. ↑ "Editorial Team". European Journal of Lipid Science and Technology. doi:10.1002/(ISSN)1438-9312. hdl:2158/1155277 . Retrieved 5 September 2018.
  12. ↑ Dutta-Roy, Asim K (2000-01-01). "Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta". The American Journal of Clinical Nutrition. 71 (1): 315s–322s. doi: 10.1093/ajcn/71.1.315s . ISSN   0002-9165. PMID   10617989.
  13. ↑ Basak, Sanjay; Mallick, Rahul; Banerjee, Antara; Pathak, Surajit; Duttaroy, Asim K. (2021-06-16). "Maternal Supply of Both Arachidonic and Docosahexaenoic Acids Is Required for Optimal Neurodevelopment". Nutrients. 13 (6): 2061. doi: 10.3390/nu13062061 . ISSN   2072-6643. PMC   8234848 . PMID   34208549.
  14. ↑ Duttaroy, Asim K.; Basak, Sanjay (2020-04-01). "Maternal dietary fatty acids and their roles in human placental development". Prostaglandins, Leukotrienes and Essential Fatty Acids. 155: 102080. doi: 10.1016/j.plefa.2020.102080 . hdl: 10852/83730 . PMID   32120190. S2CID   211833726.
  15. ↑ Duttaroy, Asim (2021-06-27). "Special Issue "Maternal DHA Impact on Child Neurodevelopment"". Nutrients. 13 (7): 2209. doi: 10.3390/nu13072209 . ISSN   2072-6643. PMC   8308222 . PMID   34199063.
  16. ↑ Ogundipe, E.; Tusor, N.; Wang, Y.; Johnson, M.R.; Edwards, A.D.; Crawford, M.A. (2018-11-01). "Randomized controlled trial of brain specific fatty acid supplementation in pregnant women increases brain volumes on MRI scans of their newborn infants". Prostaglandins, Leukotrienes and Essential Fatty Acids. 138: 6–13. doi:10.1016/j.plefa.2018.09.001. PMID   30392581. S2CID   53215840.
  17. ↑ Basak, Sanjay; Mallick, Rahul; Duttaroy, Asim K. (2020-11-25). "Maternal Docosahexaenoic Acid Status during Pregnancy and Its Impact on Infant Neurodevelopment". Nutrients. 12 (12): 3615. doi: 10.3390/nu12123615 . ISSN   2072-6643. PMC   7759779 . PMID   33255561.
  18. ↑ Mallick, Rahul; Basak, Sanjay; Duttaroy, Asim K. (2019-12-01). "Docosahexaenoic acid, 22:6n-3: Its roles in the structure and function of the brain". International Journal of Developmental Neuroscience. 79 (1): 21–31. doi:10.1016/j.ijdevneu.2019.10.004. ISSN   0736-5748. PMID   31629800. S2CID   204761373.
  19. ↑ "Professor Asim K. Duttaroy". scholar.google.com. Retrieved 2021-11-16.
  20. ↑ MedicineProfessor, Asim K. DuttaroyUniversity of Oslo · Faculty of. "Asim DUTTAROY | Professor | Professor | University of Oslo, Oslo | Faculty of Medicine". ResearchGate. Retrieved 2021-11-16.
  21. ↑ Dutta-Roy, Asim K.; Crosbie, Lynn; Gordon, Margaret J. (2001-01-01). "Effects of tomato extract on human platelet aggregation in vitro". Platelets. 12 (4): 218–227. doi:10.1080/09537100120058757. ISSN   0953-7104. PMID   11454256. S2CID   218867515.
  22. ↑ O’Kennedy, Niamh; Raederstorff, Daniel; Duttaroy, Asim K. (2017-03-01). "Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient". European Journal of Nutrition. 56 (2): 461–482. doi:10.1007/s00394-016-1265-2. ISSN   1436-6207. PMC   5334395 . PMID   27388464.
  23. ↑ "Water-soluble tomato concentrate (WSTC I and II) and platelet aggregation [1] | EFSA". www.efsa.europa.eu. 28 May 2009. doi:10.2903/j.efsa.2009.1101 . Retrieved 2021-11-15.
  24. ↑ "Water-soluble tomato concentrate (WSTC I and II) and platelet aggregation [1] | EFSA". www.efsa.europa.eu. 28 May 2009. doi:10.2903/j.efsa.2009.1101 . Retrieved 2021-11-15.
  25. ↑ O’Kennedy, Niamh; Raederstorff, Daniel; Duttaroy, Asim K. (2017-03-01). "Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient". European Journal of Nutrition. 56 (2): 461–482. doi:10.1007/s00394-016-1265-2. ISSN   1436-6207. PMC   5334395 . PMID   27388464.
  26. ↑ "Water-soluble tomato concentrate (WSTC I and II) and platelet aggregation [1] | EFSA". www.efsa.europa.eu. 28 May 2009. doi:10.2903/j.efsa.2009.1101 . Retrieved 2021-11-15.
  27. ↑ "Water-soluble tomato concentrate (WSTC I and II) and platelet aggregation [1] | EFSA". www.efsa.europa.eu. 28 May 2009. doi:10.2903/j.efsa.2009.1101 . Retrieved 2021-11-15.
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