Strobilurins are a group of natural products and their synthetic analogs. A number of strobilurins are used in agriculture as fungicides. They are part of the larger group of QoIs, which act to inhibit the respiratory chain at the level of Complex III.
Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. Over 700 species of Streptomyces bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have very large genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Different strains of the same species may colonize very diverse environments.
Streptomyces nodosus is a bacterial species in the genus Streptomyces.
Venturicidins are a group of antifungal compounds. The first member of this class was isolated from Streptomyces bacteria in 1961. Additional members of this class were subsequently isolated and characterized. An antifungal substance "aabomycin A" was isolated from Streptomyces in 1969. However, in 1990 it was reported that aabomycin A is actually a 3:1 mixture of two related components, which were then named aabomycin A1 and aabomycin A2. The structures of these were shown to be identical with those of the previously characterized compounds venturicidin A and venturicidin B, respectively. A new analog, venturicidin C, was recently reported from a Streptomyces isolated from thermal vents associated with the Ruth Mullins coal fire in Kentucky.
Asterric acid is a fungal metabolite that can inhibit endothelin binding, first isolated from Aspergillus terreus. Its derivatives and similar phenolic fungal isolates are a subject of research on anti-angiogenic compounds.
Stephacidin A and B are antitumor alkaloids isolated from the fungus Aspergillus ochraceus that belong to a class of naturally occurring 2,5-diketopiperazines. This unusual family of fungal metabolites are complex bridged 2,5-diketopiperazine alkaloids that possess a unique bicyclo[2.2.2]diazaoctane core ring system and are constituted mainly from tryptophan, proline, and substituted proline derivatives where the olefinic unit of the isoprene moiety has been formally oxidatively cyclized across the α-carbon atoms of a 2,5-diketopiperazine ring. The molecular architecture of stephacidin B, formally a dimer of avrainvillamide, reveals a complex dimeric prenylated N-hydroxyindole alkaloid that contains 15 rings and 9 stereogenic centers and is one of the most complex indole alkaloids isolated from fungi. Stephacidin B rapidly converts into the electrophilic monomer avrainvillamide in cell culture, and there is evidence that the monomer avrainvillamide interacts with intracellular thiol-containing proteins, most likely by covalent modification.
Aspergillus ustus is a microfungus and member of the division Ascomycota. It is commonly found in indoor environments and soil. Isolated cases of human infection resulting from A. ustus have been described; however the majority of these are nail infections.
Oudemansin A is a natural product first isolated from the basidiomycete fungus Oudemansiella mucida. Its chemical structure was determined by X-ray crystallography in 1979 and absolute stereochemistry by total synthesis. Two closely related derivatives, oudemansin B and X have also been isolated from other basidiomycetes. They are all biologically active against many filamentous fungi and yeasts but with insufficient potency and stability to become useful commercial products. However, their discovery, together with the strobilurins led to agricultural fungicides including azoxystrobin with the same mechanism of action.
Streptomyces amakusaensis is a bacterium species from the genus of Streptomyces which has been isolated from soil from the Amakusa Island in Japan. Streptomyces amakusaensis produces tuberin and nagstatin.
Streptomyces candidus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Russia. Streptomyces candidus produces lemonomycin, enterocin, pyrazofurin and avoparcin.
Streptomyces cirratus is a bacterium species from the genus of Streptomyces. Streptomyces cirratus produces phegomycin, phegomycin D, phegomycin DGPT, cirratiomycin A, cirramycin A and cirramycin B.
Streptomyces coeruleorubidus is a bacterium species from the genus of Streptomyces which has been isolated from marine sediment. Streptomyces coeruleorubidus produces the following medications: pacidamycin 1, baumycin B1, baumycin B2, baumycin C1, feudomycin A, feudomycin B, feudomycin C, ficellomycin, feudomycinone A, and rubomycin.
Streptomyces griseoaurantiacus is a thermotolerant bacterium species from the genus of Streptomyces which was isolated from marine sediment. Streptomyces griseoaurantiacus produces the antibiotics manumycin, diperamycin and chinikomycin, and griseolic acid.
Streptomyces griseoflavus is a bacterium species from the genus of Streptomyces which has been isolated from garden soil. Streptomyces griseoflavus produces bicozamycin, colabomycins A, colabomycins C, germacradienol and hormaomycin.
Streptomyces griseorubiginosus is a bacterium species from the genus of Streptomyces which has been isolated from soil in Russia. Streptomyces griseorubiginosus produces arylsulfatase, biphenomycin A, cinerubin A and cinerubin B.
Streptomyces lateritius is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces lateritius produces the naphthoquinone antibiotic granatomycin D.
Streptomyces roseofulvus is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces roseofulvus produces deoxyfrenolicin and frenolicin B.
Streptomyces virginiae is a bacterium species from the genus of Streptomyces which has been isolated from soil. Streptomyces virginiae produces actithiazic acid, virginiamycins and cycloserine. Streptomyces virginiae also produces monensin A, monensin B, monensin C, monensin D, actithiazic acid.
Aspergillus leporis is an anamorph species of fungus in the genus Aspergillus. It is from the Flavi section. The species was first described in 1979. It has been isolated from the dung of Lepus townsendii. Aspergillus leporis produces leporin A and leporin B. It has also been reported to produce antibiotic Y, kojic acid, and pseurotin.
Sagrario Mochales del Val is a Spanish researcher and microbiologist, known for her work in the investigation of antibiotics. She was involved in screening natural products to discover various active principles, such as the broad-spectrum antibiotic Fosfomycin, widely used in the treatment of urinary tract infections and other ailments. She also contributed to the discovery of Lovastatin, used in treating hypercholesterolemia to reduce cholesterol levels and prevent related diseases.
