Astex Pharmaceuticals

Astex Pharmaceuticals
Company type	Subsidiary
Industry	Pharmaceuticals
Founded	1999;25 years ago
Headquarters	European Corporate and Research headquarters in Cambridge, UK (Astex Therapeutics Limited);
Key people	Harren Jhoti (President and CEO); David Rees (Chief Scientific Officer);
Products	Therapeutics for oncology and CNS disorders
Parent	Otsuka Pharmaceutical
Website	astx.com

Last updated December 18, 2024

Astex Pharmaceuticals is a biotechnology company focused on the discovery and development of drugs in oncology and diseases of the central nervous system. Astex was founded in 1999 by Sir Tom Blundell,^[1]^[2] Chris Abell & Harren Jhoti,^[3] and is located in Cambridge, England.^[4]^[5]^[6]^[7]^[8]

History

Astex was founded as “Astex Technology Limited” in 1999 in Cambridge, UK, to pioneer a novel approach to small molecule drug discovery known as ‘fragment-based drug discovery’ (FBDD), a term first coined by Astex scientists (https://pubmed.ncbi.nlm.nih.gov/12650591/) that is now a well recognized approach to small molecule drug discovery across the pharmaceutical industry. Astex's proprietary drug discovery platform, Pyramid, can effectively identify novel small molecule drugs for key disease targets. Originally funded by venture capital, from a number of investors including Abingworth, Advent international, Oxford Bioscience Partners, Apax Partners and Gimv. Astex established strategic partnerships with major pharmaceutical companies including Novartis, Janssen Pharmaceuticals and GlaxoSmithKline.

In 2005, the company changed its name to Astex Therapeutics Limited when its first product entered clinical development. In 2011, Astex Therapeutics Limited and SuperGen, Inc. (US) merged.^[10] Following the acquisition, SuperGen, Inc. changed its name to Astex Pharmaceuticals, Inc., and began trading under the ticker symbol ASTX on NASDAQ.^[11] The combined Astex entities were subsequently acquired by Otsuka Pharmaceutical in October 2013 for around USD $900 million. On January 1, 2024, as part of an internal re-organization to consolidate oncology clinical development within the Otsuka group, Astex Pharmaceuticals, Inc., became part of Taiho Oncology, Inc. This internal reorganization did not impact the drug discovery research operation of Astex Pharmaceuticals (UK), based in Cambridge, UK, which continues to operate independently as ‘Astex’.

Research and development

Astex is focused on precision medicine for oncology and central nervous system disorders. This approach involves first understanding the molecular basis of a disease and then developing a targeted therapy which can arrest or reverse its progression.

Astex’s Pyramid platform^[12] is focused on the rational design of novel small molecule targeted therapies. These therapies are based on the use of biophysical techniques, principally X-ray crystallography and cryo-electron microscopy (cryo-EM), to screen and identify very small, low molecular weight fragments of drugs binding to the disease target of interest. Astex uses its knowledge of the 3-dimensional structure of the binding interaction between the compound and the target to design and grow from the initial fragment, adding further functionality to improve the affinity and selectivity of the binding interaction so that the final drug compound interacts optimally with the disease target and modulates its activity – either through inhibition or activation.

In 2020, Astex and Taiho Pharmaceutical Co., Ltd. entered into a drug discovery collaboration with Merck & Co., Inc., Kenilworth, New Jersey, USA (known as MSD outside the USA and Canada) focused on the oncogene KRAS.^[13] This collaboration was extended in 2021.^[14] In 2023 Astex announced a further collaboration with MSD to identify small molecule candidates with activity towards the tumour suppressor protein p53 for the treatment of cancer.

Clinical pipeline

Astex has a pipeline of investigational compounds currently in various stages of clinical development.

Several compounds from drug discovery collaborations with Astex have been advanced by Astex’s biopharma partners into clinical trials and onto the market, including ribociclib (brand name “Kisqali”), a CDK4/CDK6 inhibitor discovered in collaboration with Novartis that was granted approval in the US and EU in 2017 for the treatment of breast cancer.^[15] Astex's second partnered product to be approved is Erdafitinib (brand name “Balversa”) an FGFR inhibitor that was discovered with Janssen Pharmaceuticals (a subsidiary of Johnson & Johnson), and received FDA market approval for the treatment of metastatic urothelial carcinoma in 2019 subsequent to an original collaboration on FGFR inhibitors between Astex and Newcastle University.^[16] Astex’s third partnered product to reach approval is Capivasertib (brand name “Truqap”) which was discovered by AstraZeneca subsequent to its collaboration with Astex and Astex’s earlier collaboration with The Institute of Cancer Research (ICR)/Cancer Research UK (CRUK). AstraZeneca began to develop the drug as a potential treatment for various forms of cancer after its discovery in 2010. Truqap in combination with Fulvestrant (brand name “Faslodex”) was approved in the US for the treatment of adult patients with hormone receptor (HR)-positive, HER2-negative locally advanced or metastatic breast cancer with one or more biomarker alterations (PIK3CA, AKT1 or PTEN) in 2023.

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References

↑ Tom Blundell: Director Archived January 1, 2015, at the Wayback Machine on OpenCorporates
↑ Congreve, M; Murray, C. W.; Blundell, T. L. (2005). "Structural biology and drug discovery". Drug Discovery Today. 10 (13): 895–907. doi:10.1016/S1359-6446(05)03484-7. PMID 15993809.
↑ Williams, P. A.; Cosme, J; Vinkovic, D. M.; Ward, A; Angove, H. C.; Day, P. J.; Vonrhein, C; Tickle, I. J.; Jhoti, H (2004). "Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone". Science. 305 (5684): 683–6. Bibcode:2004Sci...305..683W. doi: 10.1126/science.1099736 . PMID 15256616. S2CID 23149841.
↑ Repasky, M. P.; Murphy, R. B.; Banks, J. L.; Greenwood, J. R.; Tubert-Brohman, I; Bhat, S; Friesner, R. A. (2012). "Docking performance of the glide program as evaluated on the Astex and DUD datasets: A complete set of glide SP results and selected results for a new scoring function integrating Water Map and glide". Journal of Computer-Aided Molecular Design. 26 (6): 787–99. Bibcode:2012JCAMD..26..787R. doi:10.1007/s10822-012-9575-9. PMID 22576241. S2CID 34803972.
↑ Novikov, F. N.; Stroylov, V. S.; Zeifman, A. A.; Stroganov, O. V.; Kulkov, V; Chilov, G. G. (2012). "Lead Finder docking and virtual screening evaluation with Astex and DUD test sets". Journal of Computer-Aided Molecular Design. 26 (6): 725–35. Bibcode:2012JCAMD..26..725N. doi:10.1007/s10822-012-9549-y. PMID 22569592. S2CID 22123557.
↑ Wolfson, W (2006). "Fragmentary solutions. Astex therapeutics puts the pieces together". Chemistry & Biology. 13 (8): 799–801. doi: 10.1016/j.chembiol.2006.08.003 . PMID 16931326.
↑ Mountain, V (2003). "Astex, Structural Genomix, and Syrrx. I can see clearly now: Structural biology and drug discovery". Chemistry & Biology. 10 (2): 95–8. doi: 10.1016/s1074-5521(03)00030-9 . PMID 12618177.
↑ Carr, R. A.; Congreve, M; Murray, C. W.; Rees, D. C. (2005). "Fragment-based lead discovery: Leads by design". Drug Discovery Today. 10 (14): 987–92. doi:10.1016/S1359-6446(05)03511-7. PMID 16023057.
↑ "Japan's Otsuka to buy Astex Pharma for about $900 million: Nikkei". Reuters. 4 September 2013. Retrieved 14 April 2021.
↑ "SuperGen to Merge with Astex for $25M in Cash". Genetic Engineering News. 7 April 2011. Retrieved 14 April 2021.
↑ "SuperGen, Inc. Changes Name to Astex Pharmaceuticals, Inc., Announces New Stock Ticker Symbol and New Website". BusinessWire. 12 September 2011. Retrieved 14 April 2021.
↑ "Fragment-based approaches to drug discovery" (PDF). Sp2. June 2006. Retrieved 25 March 2021.
↑ Brackley, Paul (9 January 2020). "Astex Pharmaceuticals and Taiho Pharmaceutical sign cancer drug deal with Merck that could be worth $2.5 billion". Cambridge Independent. Retrieved 25 March 2021.
↑ Brackley, Paul (21 January 2021). "Astex and Taiho strike further oncology licensing deal with MSD". Cambridge Independent. Retrieved 25 March 2021.
↑ Broderick, Jason M (14 March 2017). "FDA Approves Kisqali for Breast Cancer Subset". Cure Today. Retrieved 25 March 2021.
↑ "FDA grants accelerated approval to erdafitinib for metastatic urothelial carcinoma". U.S. Food and Drug Administration. 12 April 2019. Retrieved 14 April 2021.