Attractin

For the ATRN Extended SMTP command, see On-Demand Mail Relay.

ATRN
Identifiers
Aliases	ATRN , DPPT-L, MGCA, attractin
External IDs	OMIM: 603130; MGI: 1341628; HomoloGene: 22542; GeneCards: ATRN; OMA:ATRN - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p13 Start 3,471,018 bp [1] End 3,651,118 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 F1|2 63.26 cM Start 130,748,415 bp [2] End 130,872,253 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum lateral nuclear group of thalamus stromal cell of endometrium orbitofrontal cortex jejunal mucosa subthalamic nucleus islet of Langerhans superior vestibular nucleus external globus pallidus pons Top expressed in transitional epithelium of urinary bladder primary motor cortex subdivision of hippocampus Region I of hippocampus proper piriform cortex dentate gyrus olfactory tubercle globus pallidus dentate gyrus of hippocampal formation granule cell cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding signaling receptor activity Cellular component cytoplasm integral component of membrane extracellular region plasma membrane integral component of plasma membrane extracellular exosome membrane extracellular space Biological process myelination pigmentation inflammatory response response to oxidative stress cerebellum development regulation of multicellular organism growth animal organ morphogenesis tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8455 11990 Ensembl ENSG00000088812 ENSMUSG00000027312 UniProt O75882 Q9WU60 RefSeq (mRNA) NM_001207047 NM_012070 NM_139321 NM_139322 NM_001323332 NM_009730 RefSeq (protein) NP_001193976 NP_001310261 NP_647537 NP_647538 NP_033860 Location (UCSC) Chr 20: 3.47 – 3.65 Mb Chr 2: 130.75 – 130.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Attractin is a protein that in humans is encoded by the ATRN gene. ^{[5] [6] [7]}

Attractin is a Group XI C-type lectin.

Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000088812 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027312 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF (Oct 1998). "Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions". Proc Natl Acad Sci U S A. 95 (19): 11336–41. Bibcode:1998PNAS...9511336D. doi: 10.1073/pnas.95.19.11336 . PMC   21643 . PMID   9736737.
6. Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF (Apr 1996). "Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells". J Immunol. 156 (5): 1714–21. doi:10.4049/jimmunol.156.5.1714. PMID   8596018.
7. "Entrez Gene: ATRN attractin".

External links

• Human ATRN genome location and ATRN gene details page in the UCSC Genome Browser .

Further reading

• Mori M, Sakurai M, Araie M (1993). "[Topical timolol and blood-aqueous barrier permeability to protein in human eyes]". Nippon Ganka Gakkai Zasshi. 96 (11): 1418–22. PMID   1476071.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
• Nagle DL, McGrail SH, Vitale J, et al. (1999). "The mahogany protein is a receptor involved in suppression of obesity". Nature. 398 (6723): 148–52. Bibcode:1999Natur.398..148N. doi:10.1038/18210. PMID   10086355. S2CID   4400267.
• Gunn TM, Miller KA, He L, et al. (1999). "The mouse mahogany locus encodes a transmembrane form of human attractin". Nature. 398 (6723): 152–6. Bibcode:1999Natur.398..152G. doi:10.1038/18217. PMID   10086356. S2CID   4371433.
• Tang W, Gunn TM, McLaughlin DF, et al. (2000). "Secreted and membrane attractin result from alternative splicing of the human ATRN gene". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6025–30. Bibcode:2000PNAS...97.6025T. doi: 10.1073/pnas.110139897 . PMC   18552 . PMID   10811918.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Friedrich D, Kühn-Wache K, Hoffmann T, Demuth HU (2003). "Isolation and Characterization of Attractin-2". Dipeptidyl Aminopeptidases in Health and Disease. Advances in Experimental Medicine and Biology. Vol. 524. pp. 109–13. doi:10.1007/0-306-47920-6_14. ISBN   0-306-47717-3. PMID   12675230.
• Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID   14760718. S2CID   29261009.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Wrenger S, Faust J, Friedrich D, et al. (2007). "Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function". J. Leukoc. Biol. 80 (3): 621–9. doi:10.1189/jlb.1105678. PMID   16835316. S2CID   31858918.