BAIAP3

BAIAP3
Identifiers
Aliases	BAIAP3 , BAP3, BAI1 associated protein 3
External IDs	OMIM: 604009; MGI: 2685783; HomoloGene: 20844; GeneCards: BAIAP3; OMA:BAIAP3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 1,333,638 bp [1] End 1,349,441 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 25,461,633 bp [2] End 25,475,338 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary right frontal lobe Brodmann area 9 cingulate gyrus anterior cingulate cortex hypothalamus amygdala olfactory zone of nasal mucosa prefrontal cortex Top expressed in arcuate nucleus ventromedial nucleus dorsomedial hypothalamic nucleus median eminence paraventricular nucleus of hypothalamus suprachiasmatic nucleus lateral hypothalamus nucleus of stria terminalis central gray substance of midbrain ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin binding SNARE binding calcium ion binding protein binding phospholipid binding Cellular component presynapse endoplasmic reticulum dense core granule early endosome membrane cytosol plasma membrane late endosome membrane trans-Golgi network membrane recycling endosome membrane cytoplasm endosome Golgi apparatus membrane Biological process G protein-coupled receptor signaling pathway dense core granule maturation positive regulation of neurotransmitter secretion regulation of synaptic transmission, GABAergic positive regulation of insulin secretion involved in cellular response to glucose stimulus retrograde transport, endosome to Golgi regulation of dense core granule exocytosis exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8938 545192 Ensembl ENSG00000007516 ENSMUSG00000047507 UniProt O94812 Q80TT2 RefSeq (mRNA) NM_001199096 NM_001199097 NM_001199098 NM_001199099 NM_001286464 NM_003933 NM_001163270 RefSeq (protein) NP_001186025 NP_001186026 NP_001186027 NP_001186028 NP_001273393 NP_003924 n/a Location (UCSC) Chr 16: 1.33 – 1.35 Mb Chr 17: 25.46 – 25.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

BAI1-associated protein 3 is a protein that in humans is encoded by the BAIAP3 gene. ^{[5] [6]}

BAIAP3 was identified as a protein-binding partner of BAI1. BAI1 is a p53-target gene that encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. BAIAP3 interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. BAIAP3 also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. ^[6]

Interactions

BAIAP3 has been shown to interact with Brain-specific angiogenesis inhibitor 1. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000007516 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047507 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Nov 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochem Biophys Res Commun. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID   9790924.
6. "Entrez Gene: BAIAP3 BAI1-associated protein 3".

External links

• Human BAIAP3 genome location and BAIAP3 gene details page in the UCSC Genome Browser .

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID   15616553.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.