BAT2

PRRC2A
Identifiers
Aliases	PRRC2A , BAT2, D6S51, D6S51E, G2, proline rich coiled-coil 2A
External IDs	OMIM: 142580 MGI: 1915467 HomoloGene: 10567 GeneCards: PRRC2A
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 31,620,715 bp [1] End 31,637,771 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 18.59 cM Start 35,368,052 bp [2] End 35,383,873 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary ganglionic eminence prostate left uterine tube right uterine tube amygdala spleen right lobe of thyroid gland left lobe of thyroid gland Top expressed in superior frontal gyrus lip superior surface of tongue gallbladder yolk sac habenula cerebellar cortex spermatocyte dorsomedial hypothalamic nucleus seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component extracellular exosome membrane nucleus cytoplasm nucleoplasm cytosol plasma membrane Biological process cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7916 53761 Ensembl ENSG00000204469 ENSG00000206427 ENSG00000231825 ENSG00000231370 ENSG00000226618 ENSG00000225164 ENSG00000225748 ENSMUSG00000024393 UniProt P48634 Q7TSC1 RefSeq (mRNA) NM_004638 NM_080686 NM_001199044 NM_020027 RefSeq (protein) NP_004629 NP_542417 NP_001185973 NP_064411 Location (UCSC) Chr 6: 31.62 – 31.64 Mb Chr 17: 35.37 – 35.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene. ^{[5] [6] [7]}

Function

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene. ^[7]

Interactions

BAT2 has been shown to interact with:

• C1QBP, ^[8]
• EIF3S6, ^[8]
• HNRNPA1, ^[8]
• IFT88, ^[8]
• IMMT, ^[8] and
• UBAP2L. ^[8]

References

1. ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 GRCh38: Ensembl release 89: ENSG00000204469, ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024393 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A. 87 (6): 2374–8. Bibcode:1990PNAS...87.2374B. doi: 10.1073/pnas.87.6.2374 . PMC   53689 . PMID   2156268.
6. Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al. (Jun 1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nat Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID   8499947. S2CID   33041319.
7. "Entrez Gene: BAT2 HLA-B associated transcript 2".
8. Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.

Further reading

• Spies T, Bresnahan M, Strominger JL (1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi: 10.1073/pnas.86.22.8955 . PMC   298409 . PMID   2813433.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Singal DP, Li J, Zhu Y (2000). "HLA class III region and susceptibility to rheumatoid arthritis". Clin. Exp. Rheumatol. 18 (4): 485–91. PMID   10949724.
• Hashimoto M, Nakamura N, Obayashi H, et al. (2000). "Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitus". Hum. Genet. 105 (3): 197–9. doi:10.1007/s004390051089 (inactive 2024-03-15). PMID   10987645.
• Matsuzaka Y, Makino S, Nakajima K, et al. (2002). "New polymorphic microsatellite markers in the human MHC class III region". Tissue Antigens. 57 (5): 397–404. doi:10.1034/j.1399-0039.2001.057005397.x. PMID   11556964.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC   403804 . PMID   14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Schneiders A, Thiel S, Winkler J, et al. (2005). "Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide". Vaccine. 23 (19): 2540–50. doi:10.1016/j.vaccine.2004.08.003. PMID   15752841.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID   16083285.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• Human PRRC2A genome location and PRRC2A gene details page in the UCSC Genome Browser .