BCAR3

Last updated
BCAR3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BCAR3 , NSP2, SH2D3B, breast cancer anti-estrogen resistance 3, AND-34, NSP family adaptor protein, BCAR3 adaptor protein, NSP family member, MIG7
External IDs OMIM: 604704; MGI: 1352501; HomoloGene: 31181; GeneCards: BCAR3; OMA:BCAR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261408
NM_001261409
NM_001261410
NM_001308251
NM_003567

Contents

NM_013867
NM_001355264

RefSeq (protein)

NP_001248337
NP_001248338
NP_001248339
NP_001295180
NP_003558

NP_038895
NP_001342193

Location (UCSC) Chr 1: 93.56 – 93.85 Mb Chr 3: 122.09 – 122.32 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene. [5] [6]

Function

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137936 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028121 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC (Jul 1998). "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells". EMBO J. 17 (10): 2799–808. doi:10.1093/emboj/17.10.2799. PMC   1170620 . PMID   9582273.
  6. 1 2 "Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3".

Further reading