BCAS1

BCAS1
Identifiers
Aliases	BCAS1 , AIBC1, NABC1, breast carcinoma amplified sequence 1, brain enriched myelin associated protein 1, PMES-2
External IDs	OMIM: 602968 MGI: 1924210 HomoloGene: 2714 GeneCards: BCAS1
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.2 Start 53,936,777 bp [1] End 54,070,594 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 170,188,911 bp [2] End 170,269,765 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve corpus callosum ventral tegmental area superior vestibular nucleus middle frontal gyrus pons internal globus pallidus optic nerve amygdala subthalamic nucleus Top expressed in substantia nigra pontine nuclei globus pallidus lateral geniculate nucleus suprachiasmatic nucleus sciatic nerve ventral tegmental area anterior horn of spinal cord medial geniculate nucleus dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 8537 76960 Ensembl ENSG00000064787 ENSMUSG00000013523 UniProt O75363 Q80YN3 RefSeq (mRNA) NM_003657 NM_001316361 NM_001323347 NM_001366295 NM_001366296 NM_001366297 NM_001366298 NM_001164369 NM_029815 RefSeq (protein) NP_001303290 NP_001310276 NP_003648 NP_001353224 NP_001353225 NP_001353226 NP_001353227 NP_001157841 NP_084091 Location (UCSC) Chr 20: 53.94 – 54.07 Mb Chr 2: 170.19 – 170.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene. ^{[5] [6]}

Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000064787 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000013523 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Aug 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc Natl Acad Sci U S A. 95 (15): 8703–8. Bibcode:1998PNAS...95.8703C. doi: 10.1073/pnas.95.15.8703 . PMC   21140 . PMID   9671742.
6. "Entrez Gene: BCAS1 breast carcinoma amplified sequence 1".

External links

• Human BCAS1 genome location and BCAS1 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Tanner MM, Tirkkonen M, Kallioniemi A, et al. (1996). "Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer". Cancer Res. 56 (15): 3441–5. PMID   8758909.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Correa RG, de Carvalho AF, Pinheiro NA, et al. (2000). "NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors". Genomics. 65 (3): 299–302. doi:10.1006/geno.2000.6172. PMID   10857754.
• Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059–66. doi: 10.1074/jbc.M010320200 . PMID   11148209.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Beardsley DI, Kowbel D, Lataxes TA, et al. (2003). "Characterization of the novel amplified in breast cancer-1 (NABC1) gene product". Exp. Cell Res. 290 (2): 402–13. doi:10.1016/S0014-4827(03)00353-7. PMID   14567997.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.