BCL2L12

BCL2L12
Identifiers
Aliases	BCL2L12 , BCL2 like 12
External IDs	OMIM: 610837 MGI: 1922986 HomoloGene: 12619 GeneCards: BCL2L12
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,673,916 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,648,136 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; oocyte; ; right lobe of liver; ; appendix; ; body of pancreas; ; gastric mucosa; ; bone marrow cells; ; spleen; ; left uterine tube; ; body of stomach;
	Top expressed in
	spermatocyte; ; hand; ; yolk sac; ; maxillary prominence; ; ascending aorta; ; foot; ; lip; ; seminiferous tubule; ; thymus; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	p53 binding ; protein binding ;
Cellular component	membrane ; nucleus ;
Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ; positive regulation of transcription by RNA polymerase II ; inhibition of cysteine-type endopeptidase activity involved in apoptotic process ; negative regulation of cellular senescence ; apoptotic process ; regulation of apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	83596
	75736
	ENSG00000126453
	ENSMUSG00000003190
	Q9HB09
	n/a
NM_001040668 ; NM_001282516 ; NM_001282517 ; NM_001282519 ; NM_001282520 ;
	NM_001282521 ; NM_138639 ; NM_001385706
	NM_029410
NP_001035758 ; NP_001269445 ; NP_001269446 ; NP_001269448 ; NP_001269449 ;
	NP_001269450 ; NP_619580
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 02, 2023

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.^[5]^[6]

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[5]

Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism.^[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.^[8]

Related Research Articles

Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl-2 gene family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.

The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains, and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.

Baculoviral IAP repeat-containing protein3 is a protein that in humans is encoded by the BIRC3 gene.

Bcl-2-like protein 11, commonly called BIM, is a protein that in humans is encoded by the BCL2L11 gene.

Bcl-2-related protein A1 is a protein in humans which is encoded by the BCL2A1 gene.

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.

<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14. It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes a protein with an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.

<span class="mw-page-title-main">KLK8</span> Protein-coding gene in the species Homo sapiens

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.

Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000126453 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003190 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Bcl2L12 Bcl2-like 12 (proline rich)".
↑ Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP (March 2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.
↑ Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L (January 2007). "Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma". Genes Dev. 21 (1): 98–111. doi:10.1101/gad.1480007. PMC 1759904 . PMID 17210792.
↑ Wilson MR (August 1998). "Apoptosis: unmasking the executioner". Cell Death Differ. 5 (8): 646–52. doi: 10.1038/sj.cdd.4400394 . PMID 10200519.

External links

Human BCL2L12 genome location and BCL2L12 gene details page in the UCSC Genome Browser .

Hammond PW, Alpin J, Rise CE, et al. (2001). "In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries". J. Biol. Chem. 276 (24): 20898–906. doi: 10.1074/jbc.M011641200 . PMID 11283018.
Scorilas A, Kyriakopoulou L, Yousef GM, et al. (2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Talieri M, Diamandis EP, Katsaros N, et al. (2004). "Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors". Thromb. Haemost. 89 (6): 1081–8. doi:10.1055/s-0037-1613411. PMID 12783122. S2CID 44619207.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi: 10.1186/gb-2004-5-2-r8 . PMC 395752 . PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Mathioudaki K, Scorilas A, Papadokostopoulou A, et al. (2005). "Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer". Biol. Chem. 385 (9): 779–83. doi:10.1515/BC.2004.101. PMID 15493871. S2CID 33174333.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000126453 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003190 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Bcl2L12 Bcl2-like 12 (proline rich)".

[pmid11401436-6] Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP (March 2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics. 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.

[pmid17210792-7] Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L (January 2007). "Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma". Genes Dev. 21 (1): 98–111. doi:10.1101/gad.1480007. PMC 1759904 . PMID 17210792.

[pmid10200519-8] Wilson MR (August 1998). "Apoptosis: unmasking the executioner". Cell Death Differ. 5 (8): 646–52. doi: 10.1038/sj.cdd.4400394 . PMID 10200519.

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BCL2L12

Contents

Related Research Articles

References

External links

Further reading