BCL7A

BCL7A
Identifiers
Aliases	BCL7A , BCL7, B-cell CLL/lymphoma 7A, BCL tumor suppressor 7A, BAF complex component, BAF chromatin remodeling complex subunit SMARCJ1
External IDs	OMIM: 601406; MGI: 1924295; HomoloGene: 10869; GeneCards: BCL7A; OMA:BCL7A - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.31 Start 122,019,422 bp [1] End 122,062,044 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 123,481,897 bp [2] End 123,513,055 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone prefrontal cortex superior frontal gyrus Brodmann area 9 Cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum primary visual cortex Top expressed in hand ganglionic eminence superior cervical ganglion utricle ventricular zone olfactory system olfactory epithelium prefrontal cortex piriform cortex primary motor cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component cellular component Biological process negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 605 77045 Ensembl ENSG00000282873 ENSG00000110987 ENSMUSG00000029438 UniProt Q4VC05 Q9CXE2 RefSeq (mRNA) NM_020993 NM_001024808 NM_029850 RefSeq (protein) NP_001019979 NP_066273 NP_084126 Location (UCSC) Chr 12: 122.02 – 122.06 Mb Chr 5: 123.48 – 123.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

B-cell CLL/lymphoma 7 protein family member A is a protein that in humans is encoded by the BCL7A gene located in the chromosome 12 (Cytogenetic band: 12q24.31). ^[5]

Function

This gene codifies for a protein that belongs to the SWI/SNF chromatin remodelling complex, a complex that is able to modify the interations between DNA and histones using the energy of the ATP hydrolysis. It has found recurrently mutated in lymphomas ^[6] and silenced by promoter hypermetylation in haematological malignancies. ^{[7] [8]}

See also

• B-cell lymphoma

References

1. ENSG00000110987 GRCh38: Ensembl release 89: ENSG00000282873, ENSG00000110987 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029438 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "BCL7A BAF chromatin remodeling complex subunit BCL7A [ Homo sapiens (human) ]" . Retrieved 2019-04-28.
6. Baliñas-Gavira C, Rodríguez MI, Andrades A, Cuadros M, Álvarez-Pérez JC, Álvarez-Prado ÁF, de Yébenes VG, Sánchez-Hernández S, Fernández-Vigo E, Muñoz J, Martín F, Ramiro AR, Martínez-Climent JA, Medina PP (October 2020). "Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL" . Leukemia. 34 (10): 2722–2735. doi:10.1038/s41375-020-0919-5. ISSN   0887-6924. PMID   32576963. S2CID   219989509.
7. van Doorn R, Zoutman WH, Dijkman R, de Menezes RX, Commandeur S, Mulder AA, van der Velden PA, Vermeer MH, Willemze R, Yan PS, Huang TH, Tensen CP (2005-06-10). "Epigenetic Profiling of Cutaneous T-Cell Lymphoma: Promoter Hypermethylation of Multiple Tumor Suppressor Genes Including BCL7a, PTPRG, and p73". Journal of Clinical Oncology. 23 (17): 3886–3896. doi:10.1200/JCO.2005.11.353. ISSN   0732-183X. PMID   15897551.
8. Patiño-Mercau JR, Baliñas-Gavira C, Andrades A, Benitez-Cantos MS, Rot AE, Rodriguez MI, Álvarez-Pérez JC, Cuadros M, Medina PP (2023-03-20). "BCL7A is silenced by hypermethylation to promote acute myeloid leukemia". Biomarker Research. 11 (1): 32. doi: 10.1186/s40364-023-00472-x . ISSN   2050-7771. PMC   10026484 . PMID   36941700.

Further reading

• van Doorn R, Zoutman WH, Dijkman R, de Menezes RX, Commandeur S, Mulder AA, van der Velden PA, Vermeer MH, Willemze R, Yan PS, Huang TH, Tensen CP (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73". J. Clin. Oncol. 23 (17): 3886–96. doi: 10.1200/JCO.2005.11.353 . PMID   15897551.
• Carbone A, Bernardini L, Valenzano F, Bottillo I, De Simone C, Capizzi R, Capalbo A, Romano F, Novelli A, Dallapiccola B, Amerio P (2008). "Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF". Genes Chromosomes Cancer. 47 (12): 1067–75. doi:10.1002/gcc.20601. PMID   18663754. S2CID   205827302.
• Morton LM, Purdue MP, Zheng T, Wang SS, Armstrong B, Zhang Y, Menashe I, Chatterjee N, Davis S, Lan Q, Vajdic CM, Severson RK, Holford TR, Kricker A, Cerhan JR, Leaderer B, Grulich A, Yeager M, Cozen W, Hoar Zahm S, Chanock SJ, Rothman N, Hartge P (2009). "Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development". Cancer Epidemiol. Biomarkers Prev. 18 (4): 1259–70. doi:10.1158/1055-9965.EPI-08-1037. PMC   2716008 . PMID   19336552.
• Morton LM, Purdue MP, Zheng T, Wang SS, Armstrong B, Zhang Y, Menashe I, Chatterjee N, Davis S, Lan Q, Vajdic CM, Severson RK, Holford TR, Kricker A, Cerhan JR, Leaderer B, Grulich A, Yeager M, Cozen W, Hoar Zahm S, Chanock SJ, Rothman N, Hartge P (2009). "Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development". Cancer Epidemiol. Biomarkers Prev. 18 (4): 1259–70. doi:10.1158/1055-9965.EPI-08-1037. PMC   2716008 . PMID   19336552.
• Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR (2009). "Common genetic variants in candidate genes and risk of familial lymphoid malignancies". Br. J. Haematol. 146 (4): 418–23. doi:10.1111/j.1365-2141.2009.07790.x. PMC   2890251 . PMID   19573080.
• Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC   2928224 . PMID   19773279.
• Litvinov IV, Zhou Y, Kupper TS, Sasseville D (2013). "Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma". Leuk. Lymphoma. 54 (3): 653–4. doi:10.3109/10428194.2012.717695. PMID   22856870. S2CID   46257094.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.