BMP binding endothelial regulator

BMPER
Identifiers
Aliases	BMPER , CRIM3, CV-2, CV2, BMP binding endothelial regulator
External IDs	OMIM: 608699; MGI: 1920480; HomoloGene: 12494; GeneCards: BMPER; OMA:BMPER - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p14.3 Start 33,904,308 bp [1] End 34,156,427 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A3 Start 23,134,372 bp [2] End 23,396,496 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in upper lobe of left lung prefrontal cortex right lung cerebellar hemisphere testicle appendix right hemisphere of cerebellum gonad Brodmann area 9 stromal cell of endometrium Top expressed in calvaria left lung lobe ureter hand fossa medial ganglionic eminence trigeminal ganglion facial motor nucleus lens otic vesicle More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 168667 73230 Ensembl ENSG00000164619 ENSMUSG00000031963 UniProt Q8N8U9 Q8CJ69 RefSeq (mRNA) NM_133468 NM_001365308 NM_028472 RefSeq (protein) NP_597725 NP_082748 Location (UCSC) Chr 7: 33.9 – 34.16 Mb Chr 9: 23.13 – 23.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

BMP binding endothelial regulator is a protein that in humans is encoded by the BMPER gene. ^[5]

Transcription

KLF15 is a strong and direct activator of BMPER expression which is inhibited by SP1. BMPER is inhibited by endothelin-1, which may be mediated by endothelin inhibition of KLF15. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000164619 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031963 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: BMP binding endothelial regulator" . Retrieved 2011-09-29.
6. Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl HL, Bode C, Patterson C, Moser M (Feb 2010). "Krüppel-like factor 15 regulates BMPER in endothelial cells". Cardiovascular Research. 85 (3): 551–9. doi:10.1093/cvr/cvp314. PMC   4110462 . PMID   19767294.

External links

• Human BMPER genome location and BMPER gene details page in the UCSC Genome Browser .

Further reading

• Nagase T, Kikuno R, Ohara O (Dec 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi: 10.1093/dnares/8.6.319 . PMID   11853319.
• Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C (Aug 2003). "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation". Molecular and Cellular Biology. 23 (16): 5664–79. doi:10.1128/MCB.23.16.5664-5679.2003. PMC   166349 . PMID   12897139.
• Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F (Mar 2004). "Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins". Biochemical and Biophysical Research Communications. 315 (2): 272–80. doi:10.1016/j.bbrc.2004.01.048. PMID   14766204.
• Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, Laib A, Augustin H, Bode C, Patterson C, Moser M (Oct 2008). "BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis". Circulation Research. 103 (8): 804–12. doi: 10.1161/CIRCRESAHA.108.178434 . PMID   18787191.
• Funari VA, Krakow D, Nevarez L, Chen Z, Funari TL, Vatanavicharn N, Wilcox WR, Rimoin DL, Nelson SF, Cohn DH (Oct 2010). "BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing". American Journal of Human Genetics. 87 (4): 532–7. doi:10.1016/j.ajhg.2010.08.015. PMC   2948790 . PMID   20869035.