BMP binding endothelial regulator

BMPER
Identifiers
Aliases	BMPER , CRIM3, CV-2, CV2, BMP binding endothelial regulator
External IDs	OMIM: 608699 MGI: 1920480 HomoloGene: 12494 GeneCards: BMPER
Gene location (Human)
Chr.	Chromosome 7 (human)
End	34,156,427 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	23,396,496 bp
RNA expression pattern
	Top expressed in
	lung; ; kidney; ; adrenal gland; ; heart; ; prefrontal cortex; ; stomach; ; upper lobe of left lung; ; right lung; ; cerebellar hemisphere;
	More reference expression data
	n/a
Orthologs
	168667
	73230
	ENSG00000164619
	ENSMUSG00000031963
	Q8N8U9
	Q8CJ69
	NM_133468 ; NM_001365308
	NM_028472
	NP_597725
	NP_082748
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 13, 2022

BMP binding endothelial regulator is a protein that in humans is encoded by the BMPER gene.^[5]

Transcription

KLF15 is a strong and direct activator of BMPER expression which is inhibited by SP1. BMPER is inhibited by endothelin-1, which may be mediated by endothelin inhibition of KLF15.^[6]

Related Research Articles

Growth/differentiation factor 9 is a protein that in humans is encoded by the GDF9 gene.

Bone morphogenetic protein 7 or BMP7 is a protein that in humans is encoded by the BMP7 gene.

Bone morphogenetic protein 2 Protein-coding gene in the species Homo sapiens

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins.

Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is found on chromosome 14q22-q23.

Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in folliculogenesis, the process in which primordial follicles develop into pre-ovulatory follicles.

Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.

Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.

Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene.

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.

Bone morphogenetic protein 1 Mammalian protein found in Homo sapiens

Bone morphogenetic protein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. There are seven isoforms of the protein created by alternate splicing.

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signalling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which it phosphorylates. The Type I receptor phosphorylates an R-SMAD a transcriptional regulator.

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292.

Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily.

Growth differentiation factor 6 (GDF6) is a protein that in humans is encoded by the GDF6 gene.

G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.

Repulsive guidance molecule A (RGMa) is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. Together with BMPR1A and BMPR1B, as well as ACVR2A and BMPR2, it binds BMPs thereby activating the intracellular SMAD1/5/8 signalling pathway. In humans this protein is encoded by the RGMA gene.

Repulsive guidance molecule B (RGMb), also known as DRAGON, is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. In humans this protein is encoded by the RGMB gene.

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164619 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031963 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: BMP binding endothelial regulator" . Retrieved 2011-09-29.
↑ Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl HL, Bode C, Patterson C, Moser M (Feb 2010). "Krüppel-like factor 15 regulates BMPER in endothelial cells". Cardiovascular Research. 85 (3): 551–9. doi:10.1093/cvr/cvp314. PMC 4110462 . PMID 19767294.

External links

Human BMPER genome location and BMPER gene details page in the UCSC Genome Browser .

Nagase T, Kikuno R, Ohara O (Dec 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi: 10.1093/dnares/8.6.319 . PMID 11853319.
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C (Aug 2003). "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation". Molecular and Cellular Biology. 23 (16): 5664–79. doi:10.1128/MCB.23.16.5664-5679.2003. PMC 166349 . PMID 12897139.
Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F (Mar 2004). "Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins". Biochemical and Biophysical Research Communications. 315 (2): 272–80. doi:10.1016/j.bbrc.2004.01.048. PMID 14766204.
Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, Laib A, Augustin H, Bode C, Patterson C, Moser M (Oct 2008). "BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis". Circulation Research. 103 (8): 804–12. doi: 10.1161/CIRCRESAHA.108.178434 . PMID 18787191.
Funari VA, Krakow D, Nevarez L, Chen Z, Funari TL, Vatanavicharn N, Wilcox WR, Rimoin DL, Nelson SF, Cohn DH (Oct 2010). "BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing". American Journal of Human Genetics. 87 (4): 532–7. doi:10.1016/j.ajhg.2010.08.015. PMC 2948790 . PMID 20869035.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164619 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031963 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BMP binding endothelial regulator" . Retrieved 2011-09-29.

[pmid19767294-6] Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl HL, Bode C, Patterson C, Moser M (Feb 2010). "Krüppel-like factor 15 regulates BMPER in endothelial cells". Cardiovascular Research. 85 (3): 551–9. doi:10.1093/cvr/cvp314. PMC 4110462 . PMID 19767294.

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BMP binding endothelial regulator

Contents

Transcription

Related Research Articles

References

External links

Further reading