BRD9

BRD9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HME, 4NQN, 4UIT, 4UIU, 4UIV, 4UIW, 4XY8, 4Z6H, 4Z6I, 4YY4, 4YY6, 4YYD, 4YYG, 4YYH, 4YYI, 4YYJ, 4YYK, 5E9V, 5F1H, 5F1L, 5F2P, 5F25, 5EU1, 5IGN, 5JI8
Identifiers
Aliases	BRD9 , LAVS3040, PRO9856, bromodomain containing 9
External IDs	OMIM: 618465; MGI: 2145317; HomoloGene: 82462; GeneCards: BRD9; OMA:BRD9 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.33 Start 850,291 bp [1] End 892,824 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 C1 Start 73,937,811 bp [2] End 73,960,895 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone Achilles tendon ganglionic eminence granulocyte thymus right hemisphere of cerebellum skin of abdomen skin of leg left testis Top expressed in primary visual cortex neural layer of retina spermatocyte Region I of hippocampus proper dentate gyrus of hippocampal formation granule cell cumulus cell ventricular zone hand superior frontal gyrus granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding lysine-acetylated histone binding nucleic acid binding Cellular component cellular component SWI/SNF complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated biological process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65980 105246 Ensembl ENSG00000028310 ENSMUSG00000057649 UniProt Q9H8M2 Q3UQU0 RefSeq (mRNA) NM_001009877 NM_023924 NM_001317951 NM_001024508 NM_001308041 NM_001378947 NM_001378948 RefSeq (protein) NP_001009877 NP_001304880 NP_076413 NP_001362790 NP_001362791 NP_001362792 NP_001362806 NP_001362807 NP_001362808 NP_001019679 NP_001294970 NP_001365876 NP_001365877 Location (UCSC) Chr 5: 0.85 – 0.89 Mb Chr 13: 73.94 – 73.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bromodomain-containing protein 9 is a protein that in humans is encoded by the BRD9 gene. ^[5]

Structure and interaction

BRD9 contains a bromodomain. It is closely related to BRD7. BRD9 is present in some SWI/SNF ATPase remodeling complexes. ^[6]

Role in cancer

The BRD9 gene is frequently present in variable copy number in lung cancer. ^[7]

Small molecule inhibition

Small molecules capable of binding to the bromodomain of BRD9 have been developed. ^{[8] [9] [10]}

See also

Bromodomain

References

1. GRCh38: Ensembl release 89: ENSG00000028310 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057649 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Bromodomain containing 9".
6. Kadoch, C; Hargreaves, D. C.; Hodges, C; Elias, L; Ho, L; Ranish, J; Crabtree, G. R. (2013). "Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy". Nature Genetics. 45 (6): 592–601. doi:10.1038/ng.2628. PMC   3667980 . PMID   23644491.
7. Kang, J. U.; Koo, S. H.; Kwon, K. C.; Park, J. W.; Kim, J. M. (2008). "Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer". Cancer Genetics and Cytogenetics. 182 (1): 1–11. doi:10.1016/j.cancergencyto.2007.12.004. PMID   18328944.
8. Fedorov, O; Lingard, H; Wells, C; Monteiro, O. P.; Picaud, S; Keates, T; Yapp, C; Philpott, M; Martin, S. J.; Felletar, I; Marsden, B. D.; Filippakopoulos, P; Müller, S; Knapp, S; Brennan, P. E. (2014). "1,2,4triazolo4,3-aphthalazines: Inhibitors of diverse bromodomains". Journal of Medicinal Chemistry. 57 (2): 462–76. doi:10.1021/jm401568s. PMC   3906316 . PMID   24313754.
9. Clark, P. G.; Vieira, L. C.; Tallant, C; Fedorov, O; Singleton, D. C.; Rogers, C. M.; Monteiro, O. P.; Bennett, J. M.; Baronio, R; Müller, S; Daniels, D. L.; Méndez, J; Knapp, S; Brennan, P. E.; Dixon, D. J. (2015). "LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor". Angewandte Chemie International Edition. 54 (21): 6217–6221. doi:10.1002/anie.201501394. PMC   4449114 . PMID   25864491.
10. Theodoulou, N. H.; Bamborough, P; Bannister, A. J.; Becher, I; Bit, R. A.; Che, K. H.; Chung, C. W.; Dittmann, A; Drewes, G; Drewry, D. H.; Gordon, L; Grandi, P; Leveridge, M; Lindon, M; Michon, A. M.; Molnar, J; Robson, S. C.; Tomkinson, N. C.; Kouzarides, T; Prinjha, R. K.; Humphreys, P. G. (2015). "The Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition". Journal of Medicinal Chemistry. 59 (4): 1425–1439. doi: 10.1021/acs.jmedchem.5b00256 . PMC   7354103 . PMID   25856009.