BTG3

BTG3
Identifiers
Aliases	BTG3 , ANA, TOB5, TOB55, TOFA, BTG family member 3, BTG anti-proliferation factor 3, ANA/APRO4
External IDs	OMIM: 605674 MGI: 109532 HomoloGene: 4953 GeneCards: BTG3
Gene location (Human)
Chr.	Chromosome 21 (human)
End	17,612,945 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	78,174,080 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; ganglionic eminence; ; parotid gland; ; islet of Langerhans; ; right uterine tube; ; lower lobe of lung; ; left uterine tube; ; right lung; ; hair follicle; ; skin of abdomen;
	Top expressed in
	pancreas; ; lung; ; islet of Langerhans; ; placenta; ; lip; ; ovary; ; zone of skin; ; bone marrow; ; uterus; ; heart;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; nucleus ;
Biological process	negative regulation of cell population proliferation ; negative regulation of mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	10950
	12228
	ENSG00000281484 ; ENSG00000154640
	ENSMUSG00000022863
	Q14201 ; Q6IAU3
	P50615
	NM_001130914 ; NM_006806
	NM_001297747 ; NM_009770
	NP_001124386 ; NP_006797 ; NP_001124386.1 ; NP_006797.3
	NP_001284676 ; NP_033900
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 01, 2022

Protein BTG3 is a protein that in humans is encoded by the BTG3 gene.^[5]^[6]

Related Research Articles

Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.

Protein Tob1 is a protein that in humans is encoded by the TOB1 gene.

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex.

Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.

DNA-binding protein A is a protein that in humans is encoded by the CSDA gene.

60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene. It is a subunit of the CCR4-Not deadenylase complex.

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.

60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene.

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.

Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.

Piwi-like protein 1 is a protein that in humans is encoded by the PIWIL1 gene.

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.

Protein FAM60A is a protein that in humans is encoded by the FAM60A gene. The expression of FAM60A gene is higher in KRAS mutant non-small cell lung cancer.

Protein Tob2 is a protein that in humans is encoded by the TOB2 gene.

Protein BTG4 also known as BTG family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4). BTG4 has anti-proliferative properties and can induce G₁ cell cycle arrest.

References

1 2 3 ENSG00000154640 GRCh38: Ensembl release 89: ENSG00000281484, ENSG00000154640 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022863 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T (Jun 1998). "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system". Oncogene. 16 (20): 2687–93. doi: 10.1038/sj.onc.1201805 . PMID 9632145. S2CID 10053424.
1 2 "Entrez Gene: BTG3 BTG family, member 3".

External links

Human BTG3 genome location and BTG3 gene details page in the UCSC Genome Browser .

Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family". FEBS Lett. 497 (2–3): 67–72. doi: 10.1016/S0014-5793(01)02436-X . PMID 11377414. S2CID 43120613.
Guéhenneux F, Duret L, Callanan MB, et al. (1997). "Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle". Leukemia. 11 (3): 370–5. doi: 10.1038/sj.leu.2400599 . PMID 9067576.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID 10830953.
Birot A, Duret L, Bartholin L, et al. (2000). "Identification and molecular analysis of BANP". Gene. 253 (2): 189–96. doi:10.1016/S0378-1119(00)00244-4. PMID 10940556.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753 . PMID 11429045.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Ou YH, Chung PH, Hsu FF, et al. (2007). "The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1". EMBO J. 26 (17): 3968–80. doi:10.1038/sj.emboj.7601825. PMC 1994125 . PMID 17690688.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000154640 GRCh38: Ensembl release 89: ENSG00000281484, ENSG00000154640 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022863 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9632145-5] Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T (Jun 1998). "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system". Oncogene. 16 (20): 2687–93. doi: 10.1038/sj.onc.1201805 . PMID 9632145. S2CID 10053424.

[entrez-6] 1 2 "Entrez Gene: BTG3 BTG family, member 3".

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BTG3

Contents

Related Research Articles

References

External links

Further reading