Beta-1,3-N-acetylglucosaminyltransferase 3

B3GNT3
Identifiers
Aliases	B3GNT3 , B3GAL-T8, B3GN-T3, B3GNT-3, HP10328, TMEM3, beta3Gn-T3, Beta-1,3-N-acetylglucosaminyltransferase 3, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
External IDs	OMIM: 605863; MGI: 2152535; HomoloGene: 113516; GeneCards: B3GNT3; OMA:B3GNT3 - orthologs
EC number	2.4.1.146
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 17,794,828 bp [1] End 17,813,576 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 B3.3 Start 72,143,400 bp [2] End 72,154,433 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum gallbladder mucosa of sigmoid colon duodenum nasal epithelium minor salivary glands olfactory zone of nasal mucosa body of stomach jejunal mucosa Top expressed in epithelium of stomach duodenum pyloric antrum jejunum intestinal villus large intestine mucous cell of stomach colon left colon ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity transferase activity galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity acetylgalactosaminyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus integral component of plasma membrane membrane endoplasmic reticulum Biological process protein glycosylation poly-N-acetyllactosamine biosynthetic process keratan sulfate biosynthetic process O-glycan processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10331 72297 Ensembl ENSG00000179913 ENSMUSG00000031803 UniProt Q9Y2A9 Q5JCS9 RefSeq (mRNA) NM_014256 NM_028189 RefSeq (protein) NP_055071 NP_082465 Location (UCSC) Chr 19: 17.79 – 17.81 Mb Chr 8: 72.14 – 72.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 is an enzyme that in humans is encoded by the B3GNT3 gene. ^{[5] [6] [7]}

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000179913 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031803 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID   10072769.
6. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (May 2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family". J Biol Chem. 276 (5): 3498–507. doi: 10.1074/jbc.M004800200 . PMID   11042166.
7. "Entrez Gene: B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3".

Further reading

• Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions". Biochim. Biophys. Acta. 1473 (1): 35–53. doi:10.1016/S0304-4165(99)00168-3. PMID   10580128.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yeh JC, Hiraoka N, Petryniak B, et al. (2001). "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase". Cell. 105 (7): 957–69. doi: 10.1016/S0092-8674(01)00394-4 . PMID   11439191. S2CID   18674112.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.

External links

• B3GNT3 human gene location in the UCSC Genome Browser .
• B3GNT3 human gene details in the UCSC Genome Browser .