The plaque reduction neutralization test is used to quantify the titer of neutralizing antibody for a virus.
Brachyspira pilosicoli is a gram-negative, anaerobic, host-associated spirochete that colonizes the intestinal tract of animals and humans. It appears as a characteristic "false brush border" due to its end-on attachment to enterocytes of the colon where it interferes with intestinal absorption. B. pilosicoli is unique from other Brachyspira species because it colonizes a variety of domestic animals including pigs, chickens, dogs, wild birds, rodents, and humans. It is the causative agent of intestinal spirochetosis in pigs, chickens and humans. In particular, B. pilosicoli has been described as an important colonic pathogen of pigs and chickens, causing colitis and diarrhea resulting in depressed rates of growth and impaired production on farms where infections with B. pilosicoli may be endemic. Bacterial attachment disrupts the colonic enterocytes and associated villi, causing the symptoms characteristic of intestinal spirochetosis. Additionally, B. pilosicoli is associated with clinical disease in human infections where it has implications for public health.
Brachyspira is a genus of bacteria classified within the phylum Spirochaetota.
Campylobacter concisus is a Gram-negative, highly fastidious, mesophilic bacterium that grows under both anaerobic and microaerobic conditions with the presence of hydrogen significantly aiding growth. Motile, with either unipolar or bipolar flagella, the organisms have a characteristic spiral/corkscrew appearance and are oxidase-positive. Although the human oral cavity is the natural colonization site of the bacterium, C. concisus may also colonize the intestinal tract of some individuals. In particular, several studies have reported higher intestinal prevalence of C. concisus in patients with IBD compared to healthy controls, which has led to current speculation of the bacterium's implication in the induction of Crohn's disease.
Lactobacillus gasseri is a species in the genus Lactobacillus identified in 1980 by François Gasser and his associates. It is part of the vaginal flora. Its genome has been sequenced. L. gasseri is a normal inhabitant of the lower reproductive tract in healthy women. It also produces Lactocillin.
Lautropia mirabilis is a Gram-negative, facultatively anaerobic, oxidase- and catalase-positive, motile bacterium of the genus Lautropia and family Burkholderiaceae, isolated from the mouth of children who were infected with human immunodeficiency virus.
Inquilinus limosus is a bacterium first isolated from cystic fibrosis patients' lungs, and is rarely observed elsewhere, prompting extensive research into its biology.
Acinetobacter schindleri is a species of bacteria. It is potentially pathogenic. Its type strain is LUH 5832T.
Laribacter hongkongensis is a species of bacteria. It is facultatively anaerobic, non-sporulating, gram-negative, seagull- or spiral rod-shaped. It is a potential human pathogen. Laribacter hongkongensis has been isolated from human cases of diarrhea, but its role in causing diarrhea is unproven, even though it has been hypothesized. Additional studies are needed to better define its role as a possible enteric pathogen. These should include: case control studies designed to differentiate infection from colonization-transient passage, fulfilling Koch's postulates and Bradford-Hill's criteria on association vs. causation, possible virulence factors, animal models, host factors, antibody responses based on serodiagnostic testing, and human volunteer studies. The lessons learned from trying to establish the etiological role of the bacteria genera Aeromonas, Plesiomonas, and Edwardsiella in human diarrhea seem especially applicable for Laribacter. All four genera are isolated from extraintestinal infections, are apparently found in the aquatic environment, and epidemiological associations include eating fish and foreign travel. Even after over 50 years’ experience with the former three genera their etiological role in an individual case of human diarrhea is difficult to determine without extensive studies. For all four of these genera the critical issue will be differentiating infection from colonization or transient passage in the intestine.
Fannyhessea vaginae is a species of bacteria in the family Atopobiaceae. It is a facultative anaerobic, Gram-positive rod-shaped or elliptical coccobacillus found as single elements or in pairs or short chains. It is typically isolated from 80% of women with bacterial vaginosis and it is implicated in treatment failures. Invasive infections such as bacteremia have been reported.
Arcobacter cibarius is a species of Gram-negative, rod-shaped, slightly curved, non-spore-forming bacteria. LMG 21996T is its type strain.
Citrobacter farmeri is a Gram-negative species of bacteria.
Rothia aeria is a Gram-positive bacterium.
Neosartorya pseudofischeri is a fungus first isolated at an autopsy from a fungal lesion occurring in human neck vertebrae. Its ascospore morphology was identical to that of Aspergillus thermomutatus.
Mycoplasma salivarium is a species of bacteria in the genus Mycoplasma. This genus of bacteria lacks a cell wall around their cell membrane. Without a cell wall, they are unaffected by many common antibiotics such as penicillin or other beta-lactam antibiotics that target cell wall synthesis. Mycoplasma are the smallest bacterial cells yet discovered, and are typically about 0. 1 μm in diameter. Mycoplasma can survive without oxygen.
Bilophila wadsworthia is a Gram-negative, obligately anaerobic, catalase-positive, bile-resistant, and asaccharolytic bacillus. Approximately 75% of B. wadsworthia strains are urease positive. B. wadsworthia is linked to various diseases and is not well known due to frequent misidentification of the bacteria, and the National Center for Biotechnology Information is including it the phylum of Proteobacteria. The two unique characteristics of B. wadsworthia are the utilisation of the sulfated amino acid taurine in the production of hydrogen sulfide and the rapid catalase reaction. This bacterium is susceptible to the β-lactam antibiotics imipenem, cefoxitin, and ticarcillin.
Corynebacterium xerosis is a Gram-positive, rod-shaped bacterium in the genus Corynebacterium. Although it is frequently a harmless commensal organism living on the skin and mucus membranes, C. xerosis is also a clinically-relevant opportunistic pathogen that has been attributed to a number of different infections in animals and humans. However, its actual prominence in human medicine is up for debate due to early difficulties distinguishing it from other Corynebacterium species in clinical isolates.
Robin Patel is a Canadian born microbiologist and Elizabeth P. and Robert E. Allen Professor of Individualized Medicine, a Professor of Microbiology, and a Professor of Medicine at the Mayo Clinic. She is widely recognized as a leader in the field of clinical microbiology and has held a variety of leadership positions including 2019–2020 President of the American Society for Microbiology (ASM) and Director of the Antibacterial Resistance Leadership Group (ARLG) Laboratory Center of the National institutes of Health. She is currently the Vice Chair of Education in the Department of Laboratory Medicine and Pathology at the Mayo Clinic, and Director of the Mayo Clinic's Infectious Diseases Research Laboratory, where she studies biofilms, antimicrobial resistance, periprosthetic joint infection and diagnostic testing of bacteria.
Christensenella hongkongensis is a species of clinically relevant gram-positive coccobacilli, first isolated from patients in Hong Kong and Canada in 2006. Although the species remains relatively rare, it has a high mortality rate of up to 50%. Christensenella is thought to be broadly distributed globally, as it has been isolated from patient blood cultures around the world including Hong Kong, South Korea, New Zealand, Canada, Sweden, France and Italy. Fewer than 15 cases of C. hongkongensis have been observed worldwide.
Helicobacter cetorum is a Gram-negative, microaerophilic, spiral (helical) bacterium that is usually found in the stomachs of whales and dolphins. Based on 16S rRNA sequencing, its genome is very similar to that of Helicobacter pylori in that it can cause gastric disease in these animals. Originally isolated among Atlantic white-sided dolphins and Beluga whales in 2000, H. cetorum has been associated with hemorrhages throughout its entire gastrointestinal tract, but its role has not yet been discovered. Prior to the discovery of H. cetorum, there have not been any other Helicobacter species reported in dolphins.
