Brucella ceti

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Brucella ceti
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Hyphomicrobiales
Family: Brucellaceae
Genus: Brucella
Species:
B. ceti
Binomial name
Brucella ceti
Foster et al. 2007

Brucella ceti is a gram negative bacterial pathogen of the Brucellaceae family that causes brucellosis in cetaceans. Brucella ceti has been found in both classes of cetaceans, mysticetes and odontocetes. [1] Brucellosis in some dolphins and porpoises can result in serious clinical signs including fetal abortions, male infertility, neurobrucellosis, cardiopathies, bone and skin lesions, stranding events, and death. [1]

Contents

Brucella ceti was first isolated in 1994 when an aborted dolphin fetus was discovered. [2] Only a small portion of those with Brucella ceti have overt clinical signs of brucellosis indicating that many have the bacteria and remain asymptomatic or overcome the pathogen. Serological surveys have shown that cetacean brucellosis may be distributed worldwide in the oceans. The likely transmission route for the bacterial pathogen in cetaceans is through mating or reproduction and lactation. [1] Brucellosis is a zoonotic disease: marine mammal brucellosis can infect other species, including human beings.  

Brucella spp. are gram-negative in their staining morphology. Brucella spp. are poorly staining, small gram-negative coccobacilli (0.5-0.7 x 0.6-1.5 mm), and are seen mostly as single cells Brucella spp.JPG
Brucella spp. are gram-negative in their staining morphology. Brucella spp. are poorly staining, small gram-negative coccobacilli (0.5-0.7 x 0.6-1.5 μm), and are seen mostly as single cells

Bacterial Characteristics

B. ceti is a gram negative, non motile, aerobic bacteria. The cells are cocci, coccobacilli (short rods) with a diameter of 0.5–0.7 μm and a length of 0.6–1.5 μm. The arrangement of the cells are usually singular with occasional configurations in pairs or short chains. Cell growth occurs between 20 and 40 degrees celsius with the optimum temperature of 37 degrees celsius and is improved by the presence of blood or serum, supplemental CO2 is not required for cell growth. The ideal pH range is between 6.6 and 6.7. [3]

Host range

B. ceti has been found via PCR isolation in 4 out of 14 cetacean families but antibodies against the bacteria have been isolated in 7 families. [1] Within these families, B ceti has been cultured or found in Sowerby's beaked whales (Mesoploden bidens), longfinned pilot whales (Globicephala melas), [4] northern minke whales (Balaenoptera acutorostrata), Cuvier's beaked whale (Ziphius cavirostris), Atlantic white-sided dolphins (Lagenorhynchus acutus), harbor porpoises (Phocoena phocoena), [5] common dolphins (Delphinus delphis), white beaked dolphins (Lagenorhynchus albirostris), striped dolphins (Stenella coeruleoalba), bottlenose dolphins (Tursiops truncatus) [6] Hector's dolphins (Cephalorhynchus hectori), Maui's dolphins (Cephalorhynchus hectori maui), [7] narwhales (Monodon monoceros), killer whales (Orcinus orca) and Southern right whales (Eubalaena australis) [8]

Clinical Signs

The most common symptoms include spontaneous abortions, fatigue, anorexia, seizures, fainting and neurobrucellosis, which can lead to disorientation and stranding events . [7] Other symptoms in dolphins from both the Pacific and Atlantic oceans include subcutaneous abscesses, endometritis, meningoencephalitis and discospondylitis. [9] Post mortem pathology studies on cetaceans also find inflammatory lesions, nodules of granulation tissues and necrosis in the heart, lungs and reproductive organs. In addition to this, it is common to find non lethal lesions in the bones and joints, which indicates a chronic presence of B. ceti in cetacean populations. [1] Only a small portion of infected individuals exhibit outwardly clinically or pathological signs. [1]

Diagnosis

Most cases of B. ceti have been isolated from stranded or dead cetaceans found on the coasts. [5] Diagnostic tests involve isolating the bacteria then completing direct identification methods to characterize the microorganism or indirect screening tests to find antibodies using serological tests. [1] In most cases B. ceti is detected by PCR amplification and DNA sequencing. [7]

Treatment

Captive dolphins with B. ceti have been treated with antibiotics, however, there has been no successful treatments for brucellosis documented in cetaceans. [8]

Transmission

B. ceti is a non-mobile bacteria, unable to withstand harsh conditions outside of a host. [5] It is shown to be transmitted both horizontally through social behavior and vertically from mother to fetus. It is passed through close contact between cetaceans through sexual intercourse, reproduction and aborted fetuses. [1] B. ceti has been found in reproductive organs and in milk produced by the host. Some cetaceans species assist others in giving birth and the bacteria could be contracted this way. [5] Transmission could also occur from feeding on fish infected with brucellosis through reservoirs that have the ability to replicate in cetaceans. [1]

Epidemiology

B. ceti has been found to be distributed worldwide, with the first case in the Mediterranean documented in 2012. [1] Brucellosis is a zoonotic disease that has many different strains pertaining to different host species. [5]

There have been four confirmed cases of humans becoming infected with marine mammal brucellosis. Cetacean specific brucellosis in humans may be underestimated in African, South American and Southeast Asian countries where humans frequently come in contact with dead cetaceans. [7]

History

Brucella ceti was first isolated in 1994 when an aborted dolphin fetus was discovered. [2] The first case of B. ceti infecting the reproductive organs was recorded in a California aquarium, where bottlenose dolphins experienced abortions. The bacteria was isolated from both the fetus and the placentas. [1]

Related Research Articles

<span class="mw-page-title-main">Cetacea</span> Infraorder of mammals

Cetacea is an infraorder of aquatic mammals belonging to the order Artiodactyla that includes whales, dolphins, and porpoises. Key characteristics are their fully aquatic lifestyle, streamlined body shape, often large size and exclusively carnivorous diet. They propel themselves through the water with powerful up-and-down movement of their tail which ends in a paddle-like fluke, using their flipper-shaped forelimbs to maneuver.

<span class="mw-page-title-main">True's beaked whale</span> Species of mammal

True's beaked whale is a medium-sized whale in the genus Mesoplodon. It is native to the northern Atlantic Ocean. The common name is in reference to Frederick W. True, a curator at the United States National Museum.

<span class="mw-page-title-main">Tropical bottlenose whale</span> Species of mammal

The tropical bottlenose whale, also known as the Indo-Pacific beaked whale or Longman's beaked whale, was considered to be the world's rarest cetacean until recently, but the spade-toothed whale now holds that position. As of 2010, the species is now known from nearly a dozen strandings and over 65 sightings. This is the only species in the genus Indopacetus.

<span class="mw-page-title-main">Common dolphin</span> Species of mammal

The common dolphin is the most abundant cetacean in the world, with a global population of about six million. Despite this fact and its vernacular name, the common dolphin is not thought of as the archetypal dolphin, with that distinction belonging to the bottlenose dolphin due to its popular appearances in aquaria and the media. However, the common dolphin is often depicted in Ancient Greek and Roman art and culture, most notably in a mural painted by the Greek Minoan civilization.

Brucellosis is a zoonosis caused by ingestion of unpasteurized milk from infected animals, or close contact with their secretions. It is also known as undulant fever, Malta fever, and Mediterranean fever.

<i>Lagenorhynchus</i> Genus of mammals

Lagenorhynchus is a genus of oceanic dolphins in the infraorder Cetacea, presently containing six extant species. However, there is consistent molecular evidence that the genus is polyphyletic and several of the species are likely to be moved to other genera. In addition, the extinct species Lagenorhynchus harmatuki is also classified in this genus.

<span class="mw-page-title-main">Cetacean stranding</span> Whales or dolphins getting stuck on a beach

Cetacean stranding, commonly known as beaching, is a phenomenon in which whales and dolphins strand themselves on land, usually on a beach. Beached whales often die due to dehydration, collapsing under their own weight, or drowning when high tide covers the blowhole. Cetacean stranding has occurred since before recorded history.

<span class="mw-page-title-main">Evolution of cetaceans</span>

The evolution of cetaceans is thought to have begun in the Indian subcontinent from even-toed ungulates (Artiodactyla) 50 million years ago (mya) and to have proceeded over a period of at least 15 million years. Cetaceans are fully aquatic marine mammals belonging to the order Artiodactyla and branched off from other artiodactyls around 50 mya. Cetaceans are thought to have evolved during the Eocene, the second epoch of the present-extending Cenozoic Era. Molecular and morphological analyses suggest Cetacea share a relatively recent closest common ancestor with hippopotami and that they are sister groups. Being mammals, they surface to breathe air; they have five finger bones (even-toed) in their fins; they nurse their young; and, despite their fully aquatic life style, they retain many skeletal features from their terrestrial ancestors. Research conducted in the late 1970s in Pakistan revealed several stages in the transition of cetaceans from land to sea.

<i>Brucella</i> Genus of bacteria

Brucella is a genus of Gram-negative bacteria, named after David Bruce (1855–1931). They are small, non-encapsulated, non-motile, facultatively intracellular coccobacilli.

<i>Brucella melitensis</i> Species of bacterium

Brucella melitensis is a Gram-negative coccobacillus bacterium from the Brucellaceae family. The bacterium causes ovine brucellosis, along with Brucella ovis. It affects primarily sheep and goats, but cases have also been observed in cattle, yaks, water buffalo, Bactrian and dromedary camels, alpacas, dogs, horses and pigs. Humans can become infected if they have contact with an infected animal or its byproducts. Animals acquire B. melitensis by venereal transmission and contact with the placenta, fetus, fetal fluids, and vaginal discharges from infected animals. The organism is found in blood, urine, milk, and semen. It is zoonotic, unlike B. ovis, causing Malta fever or localized brucellosis in humans.

<i>Brucella suis</i> Bacterium that causes swine brucellosis

Brucella suis is a bacterium that causes swine brucellosis, a zoonosis that affects pigs. The disease typically causes chronic inflammatory lesions in the reproductive organs of susceptible animals or orchitis, and may even affect joints and other organs. The most common symptom is abortion in pregnant susceptible sows at any stage of gestation. Other manifestations are temporary or permanent sterility, lameness, posterior paralysis, spondylitis, and abscess formation. It is transmitted mainly by ingestion of infected tissues or fluids, semen during breeding, and suckling infected animals.

<i>Brucella abortus</i> Species of bacterium

Brucella abortus is a Gram-negative bacterium in the family Brucellaceae and is one of the causative agents of brucellosis. The rod-shaped pathogen is classified under the domain Bacteria. The prokaryotic B. abortus is non-spore-forming, non-motile and aerobic.

<i>Brucella canis</i> Species of bacterium

Brucella canis is a Gram-negative bacterium in the family Brucellaceae that causes brucellosis in dogs and other canids. It is a non-motile short-rod or coccus-shaped organism, and is oxidase, catalase, and urease positive. B. canis causes infertility in both male and female dogs. It can also cause inflammation in the eyes. The hosts of B. canis ranges from domestic animals to foxes and coyotes. It is passed from species to species via genital fluids. Treatments such as spaying, neutering, and long-term antibiotics have been used to combat B. canis. The species was first described in the United States in 1966 where mass abortions of beagles were documented. Brucella canis can be found in both pets and wild animals and lasts the lifespan of the animal it has affected. B. canis has two distinct circular chromosomes that can attribute to horizontal gene transfer.

<span class="mw-page-title-main">TRAF3IP2</span> Protein-coding gene in the species Homo sapiens

Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.

Brucella pinnipedialis is a species of bacteria. It causes infections and related diseases primarily in pinnipeds and cetaceans.

Cetacean morbillivirus (CeMV) is a virus that infects marine mammals in the order Cetacea, which includes dolphins, porpoises and whales. Three genetically distinct strains have been identified: dolphin morbillivirus (DMV), pilot whale morbillivirus (PWMV) and porpoise morbillivirus (PMV). Symptoms of infection are often a severe combination of pneumonia, encephalitis and damage to the immune system, which greatly impair the cetacean's ability to swim and stay afloat unassisted. Since its discovery in 1987, CeMV has been responsible for numerous epizootics of mass mortality in cetacean populations. Epizootics of CeMV can be easily identified by a significant increase in the number of stranded cetaceans on beaches and shores.

Brucella inopinata is a Gram-negative, nonmotile, non-spore-forming coccoid bacterium, first isolated from a breast implant infection site. Its type strain is BO1T. It is a potential cause of brucellosis.

<span class="mw-page-title-main">Globicephalinae</span> Subfamily of oceanic dolphins

Globicephalinae is a subfamily of oceanic dolphins that includes the pilot whales, the pygmy killer whale, the rough-toothed dolphin, the false killer whale, the melon-headed whale, Risso's dolphin, and the snubfin dolphins.

Helicobacter cetorum is a Gram-negative, microaerophilic, spiral (helical) bacterium that is usually found in the stomachs of whales and dolphins. Based on 16S rRNA sequencing, its genome is very similar to that of Helicobacter pylori in that it can cause gastric disease in these animals. Originally isolated among Atlantic white-sided dolphins and Beluga whales in 2000, H. cetorum has been associated with hemorrhages throughout its entire gastrointestinal tract, but its role has not yet been discovered. Prior to the discovery of H. cetorum, there have not been any other Helicobacter species reported in dolphins.

<span class="mw-page-title-main">Cetacean microbiome</span> Group of communities of microorganisms that reside within whales

The cetacean microbiome is the group of communities of microorganisms that reside within whales.

References

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Further reading