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Charles Wyatt Shields IV is an American biomedical engineer and Assistant Professor at the University of Colorado Boulder in the Department of Chemical and Biological Engineering. [1] His research involves the rational design of colloidal and supracolloidal particles for applications in drug delivery and biosensing. [2]
C. Wyatt Shields IV received a Bachelor of Science with High Distinction in Biomedical Engineering at the University of Virginia in 2011. While there, he performed undergraduate research with Jeffrey Saucerman and William Walker. [3] He continued his education and research with Gabriel López as a graduate student in Biomedical Engineering at Duke University where he obtained his PhD in 2016. During his PhD, Shields studied magnetic and acoustic methods for isolation and analysis of cells. [4]
Shields continued his academic career as a Postdoctoral Associate in Chemical and Biological Engineering at North Carolina State University where he worked with Orlin D. Velev in 2017. [5] He also worked as a Postdoctoral Fellow in Bioengineering at Harvard University with Samir Mitragotri in 2018. At Harvard's Wyss Institute, Shields developed cytokine-releasing macrophage "backpacks" that maintain a tumor-killing state in cells, travel to tumor sites, and slow their growth. [6] [7] [8]
Shields became an Assistant Professor at the University of Colorado Boulder in 2020 in the Department of Chemical and Biological Engineering. [8] He is also affiliated with the Biomedical Engineering Program, Materials Science and Engineering Program, Robotics Program, and University of Colorado Cancer Center. Working at the intersection of materials, soft matter physics, and bioengineering, Shields' research has focused on understanding how stimuli-responsive particles behave in physiological settings and how to control their assembly and motion for biological applications. [1] His lab has numerous clinical collaborations. [9] Current research includes investigating the role of immune cells in decompression sickness using lung-on-a-chip devices, [10] [11] developing "bottom-up" multifunctional magnetic microrobots, [12] [13] and using acoustically responsive particles for capture and purification of disease biomarkers. [14]
Shields' early career has resulted in numerous high profile awards, nine patents filed, and over 50 articles [15] published in journals such as Science Advances , [16] [17] Advanced Materials , [18] Advanced Functional Materials , [19] and Journal of Controlled Release . [20] Additionally, he served as a Guest Associate Editor for the journal Bioengineering & Translational Medicine and currently acts as a Review Editor for Frontiers in Acoustics. [21]
Shields' career is also distinguished by scientific outreach and mentorship. For several years, his group has partnered with a local high school on Senior Design engineering projects [22] and launching a Reverse Science Fair. [23] Shields was also recognized for his mentorship of students of diverse and underrepresented backgrounds while working under Dr. Gabriel López in 2016. [24]
At the University of Colorado Boulder, Shields has received several distinguished research awards, including a National Science Foundation (NSF) CAREER award, [22] [25] [26] Office of Naval Research (ONR) Young Investigator Program award, [27] Pew Biomedical Scholars award, [28] [29] Packard Fellowship for Science and Engineering, [13] [30] and an NIH National Institute of General Medical Sciences (NIGMS) Maximizing Investigators' Research Award (MIRA). [13] Shields is one of only 20 recipients of the Packard Fellowship at the University of Colorado Boulder. [31] Additionally, he was awarded with the Camille Dreyfus Teacher-Scholar Award in 2024. [32] [33]
Other awards and honors include:
William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering, founding Director of the Fischell Institute for Biomedical Devices, and currently the Director of the Maryland Technology Enterprise Institute in the A. James Clark School of Engineering at the University of Maryland. He was previously the Chair of the Fischell Department of Bioengineering, where he assisted in establishing the department and provided leadership that led to its nationally ranked status.
Christopher J. Chang is an American chemist and the Edward and Virginia Taylor Professor of Bioorganic Chemistry at Princeton University. Previously, he was a professor of chemistry and of molecular and cell biology at the University of California, Berkeley, where he holds the Class of 1942 Chair. Chang is also a member of the Helen Wills Neuroscience Institute, a Howard Hughes Medical Institute investigator, adjunct professor of pharmaceutical chemistry at the University of California, San Francisco, and faculty scientist at the chemical sciences division of Lawrence Berkeley Lab. He is the recipient of several awards for his research in bioinorganic chemistry, molecular and chemical biology.
Kristi S. Anseth is the Tisone Distinguished Professor of Chemical and Biological Engineering, an Associate Professor of Surgery, and a Howard Hughes Medical Investigator at the University of Colorado at Boulder. Her main research interests are the design of synthetic biomaterials using hydrogels, tissue engineering, and regenerative medicine.
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Nancy Makri is the Edward William and Jane Marr Gutgsell Endowed Professor of Chemistry and Physics at the University of Illinois Urbana–Champaign, where she is the principal investigator of the Makri Research Group for the theoretical understanding of condensed phase quantum dynamics. She studies theoretical quantum dynamics of polyatomic systems, and has developed methods for long-time numerical path integral simulations of quantum dissipative systems.
Orlin D. Velev is the INVISTA Professor in the Department of Chemical and Biomolecular Engineering at North Carolina State University. He is best known for his work in soft matter, colloid science, and nanoscience.
Laura Ann Waller is a computer scientist and Ted Van Duzer Endowed Associate Professor at the University of California, Berkeley. She was awarded a Chan Zuckerberg Initiative Fellowship to develop microscopes to image deep structures within the brain in 2017 and won the 2018 SPIE Early Career Award.
Brandi Michelle Cossairt is an American chemist specializing in synthetic inorganic and materials chemistry. She is the Lloyd E. and Florence M. West Endowed Professor of Chemistry at University of Washington.
Yuri Suzuki is a Professor of Applied Physics at Stanford University. She studies novel ground states and magnetic phenomena. She is a Fellow of the American Physical Society and an American Competitiveness and Innovation Fellow of the National Science Foundation.
Bronwen Konecky is a paleoclimatologist and climatologist whose particular area of focus lies in the past and present effect of climate change in the tropics. She is an assistant professor in the Department of Earth and Planetary Sciences at Washington University in St. Louis.
Celeste M. Nelson is a Professor of Chemical and Biological Engineering and the Director of the Program in Engineering Biology at Princeton University. She is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and was a finalist in the 2017 and 2018 Blavatnik Awards for Young Scientists.
Geoffrey "Geoff" William Coates is an American chemist and the Tisch University Professor in the department of chemistry and chemical biology at Cornell University.
Gordana Dukovic is a physical chemist. She is currently a professor in the Department of Chemistry at the University of Colorado Boulder.
Joan-Emma Shea is an American chemist who is a professor at the University of California, Santa Barbara. Her research applies statistical and computational approaches to address biological problems. She is a Fellow of both the American Physical Society and the American Chemical Society, and the editor-in-chief of the Journal of Physical Chemistry.
Songi Han is an American chemist who is a professor in the department of chemistry and biochemistry at Northwestern University. Her research considers electron and nuclear spins as sensors and detectors. She was elected a Fellow of the International Society of Magnetic Resonance in 2019 and president of the International EPR Society in 2020.
Clifford P. Brangwynne is a professor of chemical and biological engineering at Princeton University, the director of the Princeton Bioengineering Initiative, and the June K. Wu ’92 Professor in Engineering. He is also a researcher at the Howard Hughes Medical Institute.
Yi Tang is a biochemist and professor in the Department of Chemistry and Biochemistry and the Department of Chemical and Biomolecular Engineering at the University of California, Los Angeles. His research interests include the discovery, functional characterization, and engineering of natural product biosynthetic enzymes. He was awarded the 2014 Eli Lilly Award in Biological Chemistry.
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