C1QA

C1QA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PK6, 2JG8, 2JG9, 2WNU, 2WNV, 5HZF, 5HKJ
Identifiers
Aliases	C1QA , complement C1q A chain
External IDs	OMIM: 120550 MGI: 88223 HomoloGene: 7249 GeneCards: C1QA
Gene location (Human)
Chr.	Chromosome 1 (human)
End	22,639,678 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	136,626,114 bp
RNA expression pattern
	Top expressed in
	spleen; ; right lung; ; gallbladder; ; right coronary artery; ; lymph node; ; upper lobe of left lung; ; lower lobe of lung; ; gastric mucosa; ; left coronary artery; ; synovial membrane;
	Top expressed in
	spleen; ; calvaria; ; ankle; ; ankle joint; ; thymus; ; interventricular septum; ; subcutaneous adipose tissue; ; lip; ; white adipose tissue; ; optic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; serine-type endopeptidase activity ; amyloid-beta binding ;
Cellular component	extracellular region ; collagen ; complement component C1 complex ; collagen-containing extracellular matrix ; synapse ; postsynapse ; amyloid-beta complex ;
Biological process	immune system process ; complement activation ; cell-cell signaling ; complement activation, classical pathway ; response to iron ion ; innate immune response ; proteolysis ; regulation of complement activation ; human ageing ; neuron remodeling ; synapse organization ; positive regulation of astrocyte activation ; synapse pruning ; complement-mediated synapse pruning ; vertebrate eye-specific patterning ; positive regulation of neuron death ; positive regulation of microglial cell activation ;
	Sources:Amigo / QuickGO
Orthologs
	712
	12259
	ENSG00000173372
	ENSMUSG00000036887
	P02745
	P98086
	NM_015991 ; NM_001347465 ; NM_001347466
	NM_007572
	NP_001334394 ; NP_001334395 ; NP_057075
	NP_031598
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 23, 2023

Complement C1q subcomponent subunit A is a protein that in humans is encoded by the C1QA gene.^[5]

This gene encodes a major constituent of the human complement system subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173372 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036887 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sellar GC, Cockburn D, Reid KB (Mar 1992). "Localization of the gene cluster encoding the A, B, and C chains of human C1q to 1p34.1-1p36.3". Immunogenetics. 35 (3): 214–6. doi:10.1007/bf00185116. PMID 1537612. S2CID 26894430.
↑ "Entrez Gene: C1QA complement component 1, q subcomponent, A chain".

External links

Human C1QA genome location and C1QA gene details page in the UCSC Genome Browser .

Petry F (1999). "Molecular basis of hereditary C1q deficiency". Immunobiology. 199 (2): 286–94. doi:10.1016/s0171-2985(98)80033-8. PMID 9777412.
Thielens NM, Tacnet-Delorme P, Arlaud GJ (2003). "Interaction of C1q and mannan-binding lectin with viruses". Immunobiology. 205 (4–5): 563–74. doi:10.1078/0171-2985-00155. PMID 12396016.
Reid KB (1976). "Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent Clq of the first component of human complement". Biochem. J. 155 (1): 5–17. doi:10.1042/bj1550005. PMC 1172796 . PMID 7240.
Reid KB (1979). "Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement". Biochem. J. 179 (2): 367–71. doi:10.1042/bj1790367. PMC 1186634 . PMID 486087.
Krumdieck R, Höök M, Rosenberg LC, Volanakis JE (1992). "The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex". J. Immunol. 149 (11): 3695–701. doi:10.4049/jimmunol.149.11.3695. PMID 1431141.
Sellar GC, Blake DJ, Reid KB (1991). "Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q". Biochem. J. 274 (2): 481–90. doi:10.1042/bj2740481. PMC 1150164 . PMID 1706597.
Ebenbichler CF, Thielens NM, Vornhagen R, et al. (1992). "Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41". J. Exp. Med. 174 (6): 1417–24. doi:10.1084/jem.174.6.1417. PMC 2119058 . PMID 1744579.
Su H, Boackle RJ (1991). "Interaction of the envelope glycoprotein of human immunodeficiency virus with C1q and fibronectin under conditions present in human saliva". Mol. Immunol. 28 (8): 811–7. doi:10.1016/0161-5890(91)90044-K. PMID 1875953.
Busby TF, Ingham KC (1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q". Biochemistry. 29 (19): 4613–8. doi:10.1021/bi00471a016. PMID 2372546.
Bing DH, Almeda S, Isliker H, et al. (1982). "Fibronectin binds to the C1q component of complement". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4198–201. Bibcode:1982PNAS...79.4198B. doi: 10.1073/pnas.79.13.4198 . PMC 346605 . PMID 6981115.
Reid KB, Gagnon J, Frampton J (1982). "Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement". Biochem. J. 203 (3): 559–69. doi:10.1042/bj2030559. PMC 1158269 . PMID 6981411.
Stoiber H, Thielens NM, Ebenbichler C, et al. (1994). "The envelope glycoprotein of HIV-1 gp120 and human complement protein C1q bind to the same peptides derived from three different regions of gp41, the transmembrane glycoprotein of HIV-1, and share antigenic homology". Eur. J. Immunol. 24 (2): 294–300. doi:10.1002/eji.1830240203. PMID 7507842. S2CID 24908489.
Prohászka Z, Hidvégi T, Ujhelyi E, et al. (1995). "Interaction of complement and specific antibodies with the external glycoprotein 120 of HIV-1". Immunology. 85 (2): 184–9. PMC 1383879 . PMID 7642209.
Stoiber H, Ebenbichler CF, Thielens NM, et al. (1995). "HIV-1 rsgp41 depends on calcium for binding of human c1q but not for binding of gp120". Mol. Immunol. 32 (5): 371–4. doi:10.1016/0161-5890(94)00156-U. PMID 7739575.
Gulati P, Guc D, Lemercier C, et al. (1994). "Expression of the components and regulatory proteins of the classical pathway of complement in normal and diseased synovium". Rheumatol. Int. 14 (1): 13–9. doi:10.1007/BF00302666. PMID 7939135. S2CID 2144366.
Gulati P, Lemercier C, Guc D, et al. (1994). "Regulation of the synthesis of C1 subcomponents and C1-inhibitor". Behring Inst. Mitt. (93): 196–203. PMID 8172568.
Ghebrehiwet B, Lim BL, Peerschke EI, et al. (1994). "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q" (PDF). J. Exp. Med. 179 (6): 1809–21. doi:10.1084/jem.179.6.1809. PMC 2191527 . PMID 8195709.
Thielens NM, Bally IM, Ebenbichler CF, et al. (1994). "Further characterization of the interaction between the C1q subcomponent of human C1 and the transmembrane envelope glycoprotein gp41 of HIV-1". J. Immunol. 151 (11): 6583–92. doi:10.4049/jimmunol.151.11.6583. PMID 8245486.
Hidvégi T, Prohászka Z, Ujhelyi E, et al. (1994). "Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41". Clin. Exp. Immunol. 94 (3): 490–3. doi:10.1111/j.1365-2249.1993.tb08223.x. PMC 1534428 . PMID 8252810.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173372 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036887 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1537612-5] Sellar GC, Cockburn D, Reid KB (Mar 1992). "Localization of the gene cluster encoding the A, B, and C chains of human C1q to 1p34.1-1p36.3". Immunogenetics. 35 (3): 214–6. doi:10.1007/bf00185116. PMID 1537612. S2CID 26894430.

[entrez-6] "Entrez Gene: C1QA complement component 1, q subcomponent, A chain".

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C1QA

Contents

Related Research Articles

References

External links

Further reading